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A04 - Cellular responses to and molecular pathways of macrophage pyroptosis

Eicke Latz

Institute of Innate Immunity, University Hospital Bonn, University of Bonn
Contact: eicke.latzSpamProtectionuni-bonn.de
For more information visit: Latz Lab

Florian Schmidt

Institute of Innate Immunity, University Hospital Bonn, University of Bonn
Contact: fschmidtSpamProtectionuni-bonn.de
For more information visit: Schmidt Lab


The identity of most pyroptosis-dependent proinflammatory and potentially regulatory factors and their effects on surrounding cells is poorly understood. The project will study the molecular details and functional consequences of pyroptosis-dependent secreted factors and the mechanisms and kinetics of pore formation by gasdermins. These studies aim to unravel novel pathways involved in chronic tissue damage and inflammatory diseases involving pyroptosis.

Recent Publications


Budden, C.F., Gearing, L.J., Kaiser, R., Standke, L., Hertzog, P J., & Latz, E. (2021). Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses. Journal of Extracellular Vesicles 10, e12127. https://doi.org/10.1002/jev2.1212

Hepowit, N.L., Kolbe, C.-C., Zelle, S.R., Latz, E., MacGurn, J.A. (2021) Regulation of Ubiquitin and Ubiquitin-like Modifiers by Phosphorylation. The FEBS Journal 02 July 2021https://doi.org/10.1111/febs.16101

Alvarez, C.R., Kee, C., Sharma, A.,K., Thomas, L., Schmidt, F.I., Stanifer, M.L., Boulant, S., Herrmann, C. (2021) The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLOS Pathogens June 28, 2021 https://doi.org/10.1371/journal.ppat.1009687

Koenig,P.-A., Das, H., Liu, H., Kümmerer, B. M., Gohr, F. N., Jenster, L.-N., Schiffelers, L. D. J., Tesfamariam, Y. M., Uchima, M., Wuerth, J. D., Gatterdam, K., Ruetalo, N., Christensen, M., H., Fandrey, C. I., Normann, S., Tödtmann, J. M. P., Pritzl, S., Hanke, L., Boos, J., Yuan, M., Zhu, X., Schmid-Burgk, J.-L., Kato, H., Schindler, M., Wilson, I. A., Geyer, M., Ludwig, K. U., Hällberg, B. M., Wu, N. C., Schmidt, F. I. (2021) Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science Jan 12:eabe6230. doi: 10.1126/

Project related Publications