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A07 - Control of macrophage cell death in skin homeostasis and repair

Sabine Eming

Department of Dermatology

Contact: sabine.emingSpamProtectionuni-koeln.de
For more information visit: Eming Lab

Abstract

Monocytes/macrophages are an integral component of the body’s ability to restore tissue function after injury. These cells respond rapidly to pathogen- and damage-associated molecular patterns and help repair resulting tissue damage. Subsequent clearance of monocytes/macrophages from the site of injury is critical for wound healing, however it is unresolved how and to which extent cell death contributes to clearance from the wound site and how it affects the healing response. The project aims to explore how the death of wound monocytes/macrophages is regulated and how different modes of myeloid cell death regulate the healing process.

Project related Publications

Kiesewetter, A., Cursiefen, C., Eming, S.A.*, and Hos, D.* (2019). Phase-specific functions of macrophages determine injury-mediated corneal hem- and lymphangiogenesis. Sci. Rep. 9, 308. (*corresponding authors)

Do, N.N.*, Willenborg, S.*, Eckes, B., Sengle, G., Zauke, F., and Eming. S.A. (2018). Myeloid cell-restricted STAT3 signaling controls a cell autonomous anti-fibrotic repair program. J. Immunol. 201, 663-674. (* shared first authorship)

Eming, S.A., Wynn, T.A., and Martin, P. (2017) Inflammation and metabolism in tissue repair and regeneration. Science 356, 1026-1030.

Knipper, J.A.*, Willenborg, S.*, Brinckmann, J., Bloch, W., Maaß, T., Wagener, R., Krieg, T., Sutherland, T., Migge, T., Richardson, R., Hammerschmidt, M., Allen, J.E., and Eming, S.A. (2015). IL-4Rα signaling in myeloid cells controls collagen fibril assembly in skin repair. Immunity 43, 803-816. (* shared first authorship)

Ding, X., Lucas, T., Marcuzzi, G.P., Pfister, H., and Eming, S.A. (2015). Distinct functions of epidermis- and myeloid cell specific VEGF-A in human papillomavirus type 8-mediated tumorigenesis. Cancer Res. 75, 330-343.

Knuever, J.*, Willenborg*, S., Ding, X., Akyüz, M.D., Partridge, L., Niessen, C.M., Brüning, J.C., and Eming, S.A. (2015). Myeloid cell-restricted Insulin/IGF-1 receptor deficiency protects against skin inflammation. J. Immunol. 195, 5296-5308. (* shared first authorship)

Eming, S.A., Martin, P., and Tomic-Canic, M. (2014) Wound Repair and Regeneration: Mechanisms, signaling, and translation. Sci. Transl. Med. 6, 265sr6.

Willenborg, S., Lucas, T., van Loo, G., Knipper, J., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A, Ferrara, N., Pasparakis, M., and Eming, S.A. (2012). CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair. Blood 120, 613-625.

Lucas, T., Waisman, A., Ranjan, R., Roes, J., Krieg, T., Müller, W., Roers, A., and Eming, S.A. (2010). Differential roles of macrophages in diverse phases of skin repair. J. Immunol. biomarker signatures in wound exudates obtained from normal healing and chronic wounds. J Proteome Res 9:4758-4755.

Eming, S.A., Koch, M., Krieger, A., Brachvogel, B., Kreft, S., Bruckner-Tiderman, L., Krieg, T., Shannon, J.D., Fox, J.W. (2010). Differential proteomic analysis distinguishes tissue repair biomarker signatures in wound exudates obtained from normal healing and chronic wounds. J. Proteome Res. 9, 4758-4755.