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Virulence function of Bgh AVRA effectors

Isabel Saur - Assoc.

University of Cologne, Institute for Plant Science
Contact: isabel.saur(at)uni-koeln.de
For more information visit: Saur Lab


Obligate biotrophic pathogens require living host cells for proliferation and the establishment of disease symptoms. Thus, the maintenance of intact living host cells and inhibition of host cell death is of utmost importance for biotrophs. This project describes components in cell death signalling and host defence by relying on the identification of host mechanisms targeted by pathogen effectors for virulence and inhibition of cell death. For this, the Saur Emmy Noether group primarily focuses on the powdery mildew AVRA effectors which contribute to the establishment of a biotrophic lifestyle on the barley (Hordeum vulgare) host.

Recent Publications


Crean, E.E., Bilstein-Schloemer, M., Maekawa, T., Schulze-Lefert, P. and Saur, I.M.L. (2023) A dominant-negative avirulence effector of the barley powdery mildew fungus provides mechanistic insight to barley MLA immune receptor activation. J Exp Bot. doi: 10.1093/jxb/erad285

Project related Publications

Saur IML, Panstruga R, Schulze-Lefert P. (2021). NOD-like receptor-mediated plant immunity: from structure to cell death. Nature Reviews Immunology, 21(5):305-318.

Saur, I.M., Bauer, S., Kracher, B., Lu, X., Franzeskakis, L., Muller, M.C., Sabelleck, B., Kummel, F., Panstruga, R., Maekawa, T., and Schulze-Lefert, P. (2019). Multiple pairs of allelic MLA immune receptor-powdery mildew AVRA effectors argue for a direct recognition mechanism. Elife 8, e44471 

Bauer, S., Yu, D., Lawson, A.W., Saur, I.M.L., Frantzeskakis, L., Kracher, B., Logemann, E., Chai, J., Maekawa, T., Schulze-Lefert, P. (2021) The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold. PLoS Pathog, 17(2): e1009223.

Lu, X., Kracher, B., Saur, I.M.-L., Bauer, S., Ellwood, S.R., Wise, R., Yaeno, T., Maekawa, T., and Schulze-Lefert, P. (2016) Allelic barley MLA immune receptors recognize sequence-unrelated avirulence effectors of the powdery mildew pathogen. Proc Natl Acad Sci U S A 113, E6486–E6495.