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B02 - Signals and substrates of cell death proteases in plant – microbe interactions

Gunter Döhlemann

Department of Botany, CEPLAS, University of Cologne
Contact: g.doehlemann(at)uni-koeln.de
For more information visit: Döhlemann lab

Pitter Huesgen

CECAD, University of Cologne
Contact: p.huesgen(at)fz-juelich.de
For more information visit: Huesgen lab


Regulated cell death (RCD) plays a major role in determining the outcome of plant-microbe interactions. Initiation and execution of RCD often involves proteolytic activity, however little is known about the signals that activate cell death proteases, their substrates that are cleaved or degraded during RCD, the immune signals that are released by dying cells, the response by surrounding cells, and how proteases contribute to specificity and execution of different plant cell death pathways. This project aims to characterise protease-substrate relationships underlying RCD and their consequences for plant-pathogen interactions.

Recent Publications


Demir, F., Perrar, A., Mantz , M., Huesgen, P.F. (2022) Sensitive Plant N-Terminome Profiling with HUNTER. Methods Mol Biol 2022;2447:139-158. doi: 10.1007/978-1-0716-2079-3_12


Mooney, B. C., Mantz, M., Graciet, E, Huesgen, P. F. (2021) Cutting the line: manipulation of plant immunity by bacterial type III effector proteases. J Exp Bot doi:10.1093/jxb/erab095

Project related Publications