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B08 - Connecting plant sensor NLRs to host cell death responses

Jijie Chai

Institute for Biochemistry, University of Cologne
Contact: jchaiSpamProtectionuni-koeln.de
For more information visit: Chai lab

Jane Parker

Max Planck Institute for Plant Breeding Research
Contact: parkerSpamProtectionmpipz.mpg.de
For more information visit: Parker lab

Paul Schulze-Lefert

Max Planck Institute for Plant Breeding Research
Contact: schlefSpamProtectionmpipz.mpg.de
For more information visit: Schulze-Lefert lab

Abstract

Nucleotide-binding domain/leucine-rich repeat (NLR) receptors provide a crucial barrier to pathogen infection in mammals and plants. In both systems, NLRs sense microbe-mediated perturbations inside host cells and, via conformational switches, induce cell death and anti-microbial pathways leading to disease resistance. This project integrates protein structure-function studies with in vivo molecular and pathology phenotyping, genetics and cell biology to answer fundamental questions about how plant sensor NLRs activate cell death pathways and whether different NLR types converge on the same or distinct cell death machineries in immunity.

Recent Publications

2021

Sun, X., Lapin, D., Feehan, J.M., Stolze, S.C., Kramer, K., Dongus, J.A., Rzemieniewski, J., Blanvillain-Baufumé, S., Harzen, A., Bautor, J., Derbyshire, P., Menke, F.L.H., Finkemeier, I., Nakagami, H., Jones, J.D.G., & Parker, J.E.(2021) Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature Communications 12, Article number: 3335 https://doi.org/10.1038/s41467-021-23614-x

Xing, Y., Xu, N., Bhandari, D.,D., Lapin, D., Sun, X., Luo, X., Wang, Y., Cao, J., Wang, H., Coaker, G., Parker, J.,E., Liu, J. Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. The Plant Cell Koab075 https://doi.org/10.1093/plcell/koab075

Zhao, C., Tang, Y., Wang. J., Zeng, Y., Sun, H., Zheng, Z., Su, R., Schneeberger, K., Parker, J.E., Cui, H. (2021) A mis‐regulated cyclic nucleotide‐gated channel mediates cytosolic calcium elevation and activates immunity in Arabidopsis. New Phytologist doi:10.1111/nph.17218

Bauer, S., Yu, D., Lawson, A.W., Saur, I.M.L., Frantzeskakis, L., Kracher, B., Logemann, E., Chai, J., Maekawa, T., Schulze-Lefert, P. (2021) The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold. PLoS Pathog 17(2): e1009223. doi:10.1371/journal.ppat.1009223

2020

Ma, S., Lapin, D., Liu, L., Sun, Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P., Parker, J.E., Chai, J. (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science Vol. 370, Issue 6521, eabe3069; https://doi.org/10.1126/science.abe3069

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