JRG: Microglia pyroptosis in Alzheimer’s disease
Christina Ising
CECAD, University of Cologne
Contact: cising2(at)uni-koeln.de
For more information visit: Ising Lab
Abstract
Alzheimer’s disease, a tauopathy and the most common form of dementia, is characterized by accumulation of extracellular amyloid-beta and intracellular tau as well as a chronic neuroinflammation. Microglia, the innate immune cells of the brain, can be activated by tau and potentially undergo pyroptotic cell death, mediated via the NLRP3 inflammasome. However, the underlying mechanisms and the contribution of pyroptosis to the disease remain elusive. By combining mouse models with primary cell culture, this project will investigate how pyroptotic cell death of microglia is involved in the development and progression of Alzheimer’s disease.
Project related Publications
Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, VieiraSaecker A, Schwartz S, Albasset S, McManus RM, Tejera D, Griep A, Santarelli F, Brosseron F, Opitz S, Stunden J, Merten M, Kayed R, Golenbock DT, Blum D, Latz E, Buée L, Heneka MT (2019) NLRP3 inflammasome activation drives tau pathology. Nature https://doi.org/10.1038/s41586-019-1769-z