Gianmaria Liccardi | A potential new role for MLKL in mitosis independently of RIPK3
Dr. Gianmaria Liccardi
Institute for Biochemistry, University of Cologne
Contact: gianmaria.liccardi
uk-koeln.de
For more information visit: Liccardi Lab
Abstract
The overarching theme of the Liccardi lab research consists in understanding the physiological crosstalk between cell death and survival, and how this impacts on immunity. This functional interplay controls not only physiological responses but, when perturbed, can be causative of many pathologies such as cancer, autoimmune diseases, response to viral infections. The understanding of how cells undergo or avoid different modalities of cell death is central to uncover the disruption or maintenance of tissue homeostasis and how these contribute to pathological conditions. Importantly the molecular understanding of this evasion is fundamental to understand how to intervene therapeutically to either re-activate cell death (in case of cancer) or inhibit inflammation (in the case of inflammatory and autoimmune disorders). Within these overarching concepts the lab focuses on two fundamental and intercalating biological aspects: 1) Genomic Instability-induced Cell Death and Inflammation (G.I.C.D.I) and 2) Death Ligands and TNF signaling induced Cell Death and Inflammation (D.L.T.C.D.I).
Recent Publications
2025
Langpape A, Bonasera D, Stroh J, Reese M, Cartolano M, Liccardi G, von Karstedt S. Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL). Cell Death Discov. 2025 Oct 31;11(1):495. doi: 10.1038/s41420-025-02826-w. PMID: 41173858; PMCID: PMC12578790.
Hildebrandt X, Veli Ö, Hyoubi A, Zinngrebe J, Abdallah AT, Rodefeld J, Hoffmann A, Gardeweg L, Kaya Ö, Wagner E, Lindhorst A, Poggenberg M, Wang Y, Dimmler J, Schillings J, Koci P, Bonechi F, Capuccino LV, Kiefer C, Kelepouras K, Ghosh A, Noé F, Wolfrum C, Singer M, Liccardi G, Luedde T, Yavas A, Ghallab A, Hengstler JG, Antczak P, Gericke M, Winkels H, Blüher M, Walczak H, Annibaldi A, Fischer-Posovszky P, Peltzer N. Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. Sci Adv. 2025 Sep 19;11(38):eadw2539. doi: 10.1126/sciadv.adw2539. Epub 2025 Sep 17. PMID: 40961178; PMCID: PMC12442851.
Kelepouras K, Saggau J, Bonasera D, Kiefer C, Locci F, Rakhsh-Khorshid H, Grauvogel L, Varanda AB, Peifer M, Loricchio E, Montinaro A, Croon M, Trifunovic A, Prencipe G, Insalaco A, De Benedetti F, Walczak H, Liccardi G. STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09536-4. Epub ahead of print. PMID: 40834903.
Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X. doi: 10.1016/j.molcel.2025.03.015. Epub vor dem Druck. PMID: 40209701