CP04 | Proteomic dissection of cell death-mediated protein release and proteolysis
Prof. Dr. Pitter Huesgen
Institute of Biology II, University of Freiburg
Contact: pitter.huesgen
biologie.uni-freiburg.de
For more information visit: Huesgen lab
Prof. Dr. Felix Meissner
Institute for Innate Immunity, University Bonn
Contact: felix.meissneruni-bonn.de
For more information visit: Meissner lab
Abstract
This project is funded within the 2nd funding period of the SFB 1403, starting from 2024
This core project aims to i) develops tailored mass spectrometry-based approaches for the comprehensive analysis of cell death released proteins and protease substrates in both mammalian and plant systems and ii) advise all interested CRC members on experimental design and execution of proteomics experiments, including sample preparation, measurement and initial data analysis, and contribute to data interpretation and dissemination. Thus, this core project will provide essential tools and expertise to decipher the mechanisms underlying the cross-talk between dying and bystander cells.
Recent Publications
2025
Mantz M, Dewes P, Huesgen PF. Terminomics for plant protease substrate discovery: Achievements, challenges and new opportunities. J Exp Bot. 2025 May 4:eraf173. doi: 10.1093/jxb/eraf173. Epub ahead of print. PMID: 40319448.