Nagata M, Carvalho Schäfer Y, Wachsmuth L, Pasparakis M. A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses. EMBO J. 2024 Sep 19. doi: 10.1038/s44318-024-00238-7. Epub ahead of print. PMID: 39300211.

Koerner L, Wachsmuth L, Kumari S, Schwarzer R, Wagner T, Jiao H, Pasparakis M. ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell Death Differ. 2024 Jun 7. doi: 10.1038/s41418-024-01321-6. Epub ahead of print. PMID: 38849574.

Imai T, Lin J, Kaya G, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M. 1,2,4. The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity 57, 1–17, https://doi.org/10.1016/j.immuni.2024.04.016

Eren, R.O., Kaya, G.G., Schwarzer, R. and Pasparakis, M. (2024). IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 15, 130. doi: 10.1038/s41467-023-44372-y.

Moschandrea, C., Kondylis, V., Evangelakos, I., Herholz, M., Schneider, F., Schmidt, C., Yang, M., Ehret, S., Heine, M., Jaeckstein, M.Y., Szczepanowska, K., Schwarzer, R., Baumann, L., Bock, T., Nikitopoulou, E., Brodesser, S., Krüger, M., Frezza, C., Heeren, J., Trifunovic, A., and Pasparakis, M. (2023). Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 20. doi: 10.1038/s41586-023-06857-0.

Schorn, F., Werthenbach, J.P., Hoffmann, M., Daoud, M., Stachelscheid, J., Schiffmann, L.M., Hildebrandt, X., Lyu, S.I., Peltzer, N., Quaas, A., Vucic, D., Silke, J., Pasparakis, M. and Kashkar, H. (2023) cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. doi: 10.15252/embj.2023113614

Injarabian, L., Willenborg, S., Welcker, D., Sanin, D.E., Pasparakis, M., Kashkar, H. and Eming, S.A. (2023) FADD- and RIPK3-mediated cell death ensures clearance of Ly6C^high wound macrophages from damaged tissue. J Invest Dermatol. doi: 10.1016/j.jid.2023.06.203.

Imai, T., Van, TM., Pasparakis, M., Polykratis, A. (2022). Smooth muscle cell specific NEMO deficiency inhibits atherosclerosis in ApoE^−/− mice. Sci Rep12, 12538 (2022). https://doi.org/10.1038/s41598-022-16737-8

Jiao, H., Wachsmuth, L., Wolf, S., Lohmann, J., Nagata, M., Kaya, G. G., Oikonomou, N., Kondylis, V., Rogg, M., Diebold, M., Tröder, S.E., Zevnik, B., Prinz, M., Schell, C., Young, G.R., Kassiotis, G: & Pasparakis, M. (2022) ADAR1 averts fatal type I interferon induction by ZBP1. Nature (2022). https://doi.org/10.1038/s41586-022-04878-9

Theobald, S.J., Gräb, J., Fritsch, M., Suárez, I., Eisfeld, H.S., Winter, S., Koch, M., Hölscher, C., Pasparakis, M., Kashkar, H., and Rybniker, J. (2021) Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov.7, 327 (2021). https://doi.org/10.1038/s41420-021-00716-5

Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M.,  Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J.U.G., Bojkova, D., Shumliakivska, M., [...] Altmeppen, H.C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V., & Schwaninger, M. (2021) The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci.https://doi.org/10.1038/s41593-021-00926-1

Schünke, H., Göbel, U., Dikic, I., Pasparakis, M. (2021). OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nature Communications 12, Article Number: 5912 https://doi.org/10.1038/s41467-021-25945-1

Oikonomou, N., Schuijs, M.J., Chatzigiagkos, A., Androulidaki, A., Aidinis, V., Hammad, H., Lambrecht, B.N., and Pasparakis, M. (2021) Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunology https://doi.org/10.1038/s41385-021-00415-5

Kumari, S., Van, T.-M., Preukschat, D., Schuenke, H., Basic, M., Bleich, A., Klein, U., Pasparakis, M. (2021) NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation.Life Science Alliance 15 April 2021. DOI: 10.26508/lsa.202000956

Laurien, L., Nagata, M., Schünke, H., Delanghe, T., Wiederstein, J., L.,  Kumari, S., Schwarzer, R., Corona, T., Krüger, M., Bertrand, M., J., M., Kondylis, V. & Pasparakis, M. (2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation.Nat. Comm. Volume 11, Article number: 1747. https://doi.org/10.1038/s41467-020-15466-8

Schwarzer, R., Jiao, H., Wachsmuth, L., Tresch, A., Pasparakis, M. (2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells.Immunity Volume 52, Pages 1-16. https://doi.org/10.1016/j.immuni.2020.04.002 For free acces please go here

Schwarzer, R., Laurien, L., Pasparakis, M. (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Curr. Opin. Cell Biol. Volume 63, Pages 186-193. https://doi.org/10.1016/j.ceb.2020.02.004

Jiao, H., Wachsmuth, L., Kumari, S., Schwarzer, R., Lin, J., Eren, R., O., Fisher, A., Lane, R., Young, G., R.,  Kassiotis, G., Kaiser W., J., Pasparakis, M. (2020). Z-nucleic-acid sensing triggers ZBP1dependent necroptosis and inflammation.Nature, https://doi.org/10.1038/s41586-020-2129-8

Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagichi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G,* Pasparakis, M.* (2019) A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin binding domain. Nat. Cell Biol. 21, 731-742.

Lin, J., Kumari, S., Kim, C., Van, T.M., Wachsmuth, L., Polykratis, A., and Pasparakis, M.* (2016). RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature 540, 124-128.

Vlantis, K., Wullaert, A., Polykratis, A., Kondylis, V., Dannappel, M., Schwarzer, R., Welz, P., Corona, T., Walczak, H., Weih, F., Klein, U., Kelliher, M. and Pasparakis, M.* (2016). NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions. Immunity 44, 553-567.

Kondylis, V., Polykratis, A., Ehlken, H., Ochoa-Callejero, L., Straub, B.K., Krishna-Subramanian, S., Van, T.M., Curth, H.M., Heise, N., Weih, F., Klein, U., Schirmacher, P., Kelliher, M. and Pasparakis, M.* (2015). NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell 28, 582-598.

Dannappel, M., Vlantis, K., Kumari, S., Polykratis, A., Kim, C., Wachsmuth, L., Eftychi, C., Lin, J., Corona, T., Hermance, N., Zelic, M., Kirsch, P., Basic, M., Bleich, A., Kelliher, M. & Pasparakis, M.* (2014). RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513, 90-94.

Ehlken, H., Krishna-Subramanian, S., Ochoa-Callejero, L., Kondylis, V., Nadi, N.E., Straub, B.K., Schirmacher, P., Walczak, H., Kollias, G., and Pasparakis, M.* (2014). Death receptor-independent FADD signalling triggers hepatitis and hepatocellular carcinoma in mice with liver parenchymal cell-specific NEMO knockout. Cell Death Differ 21, 1721-1732.

Kumari, S., Redouane, Y., Lopez-Mosqueda, J., Shiraishi, R., Romanowska, M., Lutzmayer, S., Kuiper, J., Martinez, C., Dikic, I.,* Pasparakis, M.,* and Ikeda, F.* (2014). Sharpin prevents skin inflammation by inhibiting TNFR1-induced keratinocyte apoptosis. Elife 3.

Bonnet, M.C., Preukschat, D., Welz, P.S., van Loo, G., Ermolaeva, M.A., Bloch, W., Haase, I., and Pasparakis, M.* (2011). The adaptor protein FADD protects epidermal keratinocytes from necroptosis in vivo and prevents skin inflammation. Immunity 35, 572-582.

Welz, P.S., Wullaert, A., Vlantis, K., Kondylis, V., Fernandez-Majada, V., Ermolaeva, M., Kirsch, P., Sterner-Kock, A., van Loo, G., and Pasparakis, M.* (2011). FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477, 330-334.

Nenci, A., Becker, C., Wullaert, A., Gareus, R., van Loo, G., Danese, S., Huth, M., Nikolaev, A., Neufert, C., Madison, B., Gumucio, D., Neurath, M.F., and Pasparakis, M.* (2007). Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446, 557-561.

*Corresponding authors