A12 | The role of a new E3 ligase in regulating cell death and inflammation in immune signaling
Prof. Dr. Henning Walczak
Department of Biochemistry I - CECAD - University of Cologne
Contact: h.walczak
uni-koeln.de
For more information visit: Walczak lab
Abstract
This project is funded within the 2nd funding period of the SFB 1403, starting from 2024
Recent Publications
2025
Theobald SJ, Dahm K, Lange D, Spintge JB, Winter S, Klingmüller A, Holsten L, Simonis A, De Domenico E, Walczak H, van Uelft M, Schultze JL, Beyer MD, Ulas T, Suárez I, Rybniker J. Deep immune profiling delineates hallmarks of disease heterogeneity in extrapulmonary tuberculosis. Nat Commun. 2025 Nov 10;16(1):9662. doi: 10.1038/s41467-025-65561-x. PMID: 41213960; PMCID: PMC12603278.
Hildebrandt X, Veli Ö, Hyoubi A, Zinngrebe J, Abdallah AT, Rodefeld J, Hoffmann A, Gardeweg L, Kaya Ö, Wagner E, Lindhorst A, Poggenberg M, Wang Y, Dimmler J, Schillings J, Koci P, Bonechi F, Capuccino LV, Kiefer C, Kelepouras K, Ghosh A, Noé F, Wolfrum C, Singer M, Liccardi G, Luedde T, Yavas A, Ghallab A, Hengstler JG, Antczak P, Gericke M, Winkels H, Blüher M, Walczak H, Annibaldi A, Fischer-Posovszky P, Peltzer N. Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. Sci Adv. 2025 Sep 19;11(38):eadw2539. doi: 10.1126/sciadv.adw2539. Epub 2025 Sep 17. PMID: 40961178; PMCID: PMC12442851.
Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. Epub ahead of print. Erratum in: Nature. 2025 Sep 19. doi: 10.1038/s41586-025-09638-z. PMID: 40931078.
Kelepouras K, Saggau J, Bonasera D, Kiefer C, Locci F, Rakhsh-Khorshid H, Grauvogel L, Varanda AB, Peifer M, Loricchio E, Montinaro A, Croon M, Trifunovic A, Prencipe G, Insalaco A, De Benedetti F, Walczak H, Liccardi G. STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09536-4. Epub ahead of print. PMID: 40834903.
Posor Y, Conduit SE, Pearce W, Morelli D, Constantinou G, Whitehead M, Sebire NJ, Scudamore CL, Peltzer N, Walczak H, Vanhaesebroeck B. Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2423358122. doi: 10.1073/pnas.2423358122. Epub 2025 Jul 17. PMID: 40674428; PMCID: PMC12304892.
Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X. doi: 10.1016/j.molcel.2025.03.015. Epub vor dem Druck. PMID: 40209701