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Hildebrandt X, Veli Ö, Hyoubi A, Zinngrebe J, Abdallah AT, Rodefeld J, Hoffmann A, Gardeweg L, Kaya Ö, Wagner E, Lindhorst A, Poggenberg M, Wang Y, Dimmler J, Schillings J, Koci P, Bonechi F, Capuccino LV, Kiefer C, Kelepouras K, Ghosh A, Noé F, Wolfrum C, Singer M, Liccardi G, Luedde T, Yavas A, Ghallab A, Hengstler JG, Antczak P, Gericke M, Winkels H, Blüher M, Walczak H, Annibaldi A, Fischer-Posovszky P, Peltzer N. Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. Sci Adv. 2025 Sep 19;11(38):eadw2539. doi: 10.1126/sciadv.adw2539. Epub 2025 Sep 17. PMID: 40961178; PMCID: PMC12442851.

Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. Epub ahead of print. Erratum in: Nature. 2025 Sep 19. doi: 10.1038/s41586-025-09638-z. PMID: 40931078.

Kelepouras K, Saggau J, Bonasera D, Kiefer C, Locci F, Rakhsh-Khorshid H, Grauvogel L, Varanda AB, Peifer M, Loricchio E, Montinaro A, Croon M, Trifunovic A, Prencipe G, Insalaco A, De Benedetti F, Walczak H, Liccardi G. STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09536-4. Epub ahead of print. PMID: 40834903.

Posor Y, Conduit SE, Pearce W, Morelli D, Constantinou G, Whitehead M, Sebire NJ, Scudamore CL, Peltzer N, Walczak H, Vanhaesebroeck B. Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2423358122. doi: 10.1073/pnas.2423358122. Epub 2025 Jul 17. PMID: 40674428; PMCID: PMC12304892.

Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.  doi: 10.1016/j.molcel.2025.03.015. Epub vor dem Druck. PMID: 40209701

Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. PMID: 39542886; PMCID: PMC11564195.

Chen YG, Rieser E, Bhamra A, Surinova S, Kreuzaler P, Ho MH, Tsai WC, Peltzer N, de Miguel D, Walczak H. LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB. Cell Death Differ. 2024 Aug 30. doi: 10.1038/s41418-024-01355-w. Epub ahead of print. PMID: 39215104.

Veli Ö, Kaya Ö, Varanda AB, Hildebrandt X, Xiao P, Estornes Y, Poggenberg M, Wang Y, Pasparakis M, Bertrand MJM, Walczak H, Annibaldi A, Cardozo AK, Peltzer N. RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia. Mol Metab. 2024 Jul 12:101988. doi: 10.1016/j.molmet.2024.101988. Epub ahead of print. PMID: 39004142.

Kelepouras K, Saggau J, Varanda AB, Zrilic M, Kiefer C, Rakhsh-Khorshid H, Lisewski I, Uranga-Murillo I, Arias M, Pardo J, Tonnus W, Linkermann A, Annibaldi A, Walczak H, Liccardi G. The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo. Cell Death Differ. 2024 May 23. doi: 10.1038/s41418-024-01313-6. Epub ahead of print. PMID: 38783091.

Oda H, Manthiram K, Chavan PP, Rieser E, Veli Ö, Kaya Ö, Rauch C, Nakabo S, Kuehn HS, Swart M, Wang Y, Çelik NI, Molitor A, Ziaee V, Movahedi N, Shahrooei M, Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nat Immunol. 2024 Apr 12. doi: 10.1038/s41590-024-01817-w. Epub ahead of print. PMID: 38609546.

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Theobald, S. J., Simonis, A., Mudler, J.M.,…, Walczak, H.,... , and Rybniker J. (2022). Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med 14, e15888.

Jain, R., Zhao, K., Sheridan, J.M., Heinlein, M., Kupresanin, F., Abeysekera, W., Hall, C., Rickard, J., Bouillet, P., Walczak, H., Strasser, A., Silke, J., and Gray, D.H.D. (2021). Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death Differ 28, 2946-2956.

Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A.-L., Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke, J., and Walczak, H. (2022). Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differ 29, 492–503.

Lafont, E., Draber, P., Rieser, E., Reichert, M., Kupka, S., de Miguel, D., Draberova, H., von Mässenhausen, A., Bhamra, A., Henderson, S., Wojdyla, K., Chalk, A., Surinova, S., Linkermann, A., and Walczak, H. (2018). TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation. Nat Cell Biol 20, 1389–1399.

Peltzer, N., Darding, M., Montinaro, A., Draber, P., Draberova, H., Kupka, S., Rieser, E., Fisher, A., Hutchinson, C., Taraborrelli, L., Hartwig, T., Lafont, E., Haas, T.L., Shimizu, Y., Böiers, C., Sarr, A., Rickard, J., Alvarez-Diaz, S., Ashworth, M.T., Beal, A., Enver, T., Bertin, J., Kaiser, W., Strasser, A., Silke, J., Bouillet, P., and Walczak, H. (2018). LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature 557, 112–117.

Hartwig, T., Montinaro, A., von Karstedt, S., Sevko, A., Surinova, S., Chakravarthy, A., Taraborrelli, L., Draber, P., Lafont, E., Arce Vargas, F., El-Bahrawy, M.A., Quezada, S.A., and Walczak, H. (2017). The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell 65, 730-742.e5.

Zinngrebe, J., Rieser, E., Taraborrelli, L., Peltzer, N., Hartwig, T., Ren, H., Kovács, I., Endres, C., Draber, P., Darding, M., von Karstedt, S., Lemke, J., Dome, B., Bergmann, M., Ferguson, B.J., and Walczak, H. (2016). LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. J Exp Med 213, 2671–2689.

Kupka, S., De Miguel, D., Draber, P., Martino, L., Surinova, S., Rittinger, K., and Walczak, H. (2016). SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep 16, 2271–2280.

Draber, P., Kupka, S., Reichert, M., Draberova, H., Lafont, E., de Miguel, D., Spilgies, L., Surinova, S., Taraborrelli, L., Hartwig, T., Rieser, E., Martino, L., Rittinger, K., and Walczak, H. (2015). LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Cell Rep 13, 2258–2272.

Gerlach, B., Cordier, S.M., Schmukle, A.C., Emmerich, C.H., Rieser, E., Haas, T.L., Webb, A.I., Rickard, J.A., Anderton, H., Wong, W.W.-L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A.W., Silke, J., and Walczak, H. (2011). Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471, 591–596.

Patents:

“A method for treating diseases of acute organ failure, including those caused by airway targeting viruses, such as Acute Respiratory Distress Syndrome, and related diseases”. UCL Business PLC; Filed: 18/10/20. Inventors: H. Walczak, N. Peltzer, et al..,

“A method for treating diseases by combined inhibition of TNF superfamily members and/or cell death signalling pathways” UCL Business PLC; Filed: 22/01/18, Inventors: H. Walczak, N. Peltzer, L. Taraborrelli. “Allosteric regulation of MLKL activity and inhibitors thereof” UCL Business PLC/University of Tübingen. Inventors: A. Garcia Saez, … H. Walczak*, N. Peltzer* (*equal contribution)