B01 | KASHKAR & FRITSCH
Role of apoptotic caspases in macrophage-mediated anti-bacterial immunity
Research area B: Cell Death mechanisms in host defence
Work in research area B focuses on the mechanisms and function of RCD in host-microbe interactions. Where cell death is an integral component of host defence in both animals and plants, the mechanisms that govern the regulation and execution of specific types of cell death in response to microbes as well as the functional implications for the outcome of the infection remain poorly understood. Groups of the CRC will use multidisciplinary approaches to dissect the molecular pathways that regulate host cell death in response to microbial exposure. 8 projects studies in animal and plant model organisms to assess the role of different pathways of RCD in host responses to pathogenic or symbiotic microbes.
B02 | DÖHLEMANN & MISAS VILAMIL
Cell death signalling peptides in maize immunity
B03 | ZUCCARO
Cell death regulation and function in plant-fungal symbiosis
B05 | RYBNIKER
Mechanisms and consequences of inflammasome mediated mitochondrial impairment in Mycobacterium tuberculosis infected myeloid cells
B06 | HOFMANN
The evolution of regulated necrotic cell death
B07 | GARCIA-SAEZ & MAEKAWA
Ultra-structure of the plasma membrane harbouring MLKL oligomers and MLKL-mediated Ca2+ influx during plant and animal immunogenic cell death
B08 | PARKER
Connecting plant TIR-domain NLR receptors to host cell death and pathogen resistance
B09 | SAUR
Immune-related cell death pathways as targets of fungal virulence strategies