A13 - Contribution of microglia cell death to tau pathology in Alzheimer’s disease and other tauopathies
Christina Ising
CECAD, University of Cologne
Contact: cising2(at)uni-koeln.de
For more information visit: Ising Lab
Abstract
This project is funded within the 2nd funding period of the SFB 1403, starting from 2024
Alzheimer’s disease, a tauopathy and the most common form of dementia, is characterized by accumulation of extracellular amyloid-beta and intracellular tau as well as a chronic neuroinflammation. Microglia, the innate immune cells of the brain, can be activated by tau and potentially undergo pyroptotic cell death, mediated via the NLRP3 inflammasome. However, the underlying mechanisms and the contribution of microglial pyroptosis to the disease remain elusive. By combining mouse models with primary cell culture, this project will investigate how pyroptotic cell death and especially the pyroptotic pore protein Gasdermin D (GSDMD) are involved in the development and progression Alzheimer’s disease and other tauopathies.
