UNIVERSITÄT ZU KÖLN

Gries, R., Chhen, .J, van Gumpel, E., Theobald, S.J., Sonnenkalb, L., Utpatel, C., Metzen, F., Koch, M., Dallenga, T., Djaout, K., Baulard, A., Dal Molin, M., and Rybniker, J. (2023). Discovery of dual-active ethionamide boosters inhibiting the Mycobacteriumtuberculosis ESX-1 secretion system. Cell Chem Biol. S2451-9456(23)00436-1. doi: 10.1016/j.chembiol.2023.12.007. Epub ahead of print. PMID: 38181799.

B05 - Rybniker - Abstract

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Moschandrea, C., Kondylis, V., Evangelakos, I., Herholz, M., Schneider, F., Schmidt, C., Yang, M., Ehret, S., Heine, M., Jaeckstein, M.Y., Szczepanowska, K., Schwarzer, R., Baumann, L., Bock, T., Nikitopoulou, E., Brodesser, S., Krüger, M., Frezza, C., Heeren, J., Trifunovic, A., and Pasparakis, M. (2023). Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 20. doi: 10.1038/s41586-023-06857-0.

A01 - Pasparakis - Abstract

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Eren, R.O., Kaya, G.G., Schwarzer, R. and Pasparakis, M. (2024). IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 15, 130. doi: 10.1038/s41467-023-44372-y.

A01 - Pasparakis - Abstract

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Nickenig, M., Mangan, M.S.J., Lee, H.E., Symeonidis, K., Henne, A., Kaiser, R., Geißmar, E., Garritsen, H., Abdullah, Z., Hiller, K., Latz, E., and Lauterbach, M.A. (2024). Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol. 2024 212, 7-11. doi: 10.4049/jimmunol.2200835.

A04 - Latz - Abstract

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Kopp, A., Hagelueken, G., Jamitzky, I., Moecking, J., Schiffelers, L.D.J., Schmidt, F.I., and Geyer, M. (2023) Pyroptosis inhibiting nanobodies block Gasdermin D pore formation. Nat Commun.  14, 7923. doi: 10.1038/s41467-023-43707-z.

A04 - Schmidt - Abstract

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Teague, H.C., Lefevre, C., Rieser, E., Wolfram, L., de Miguel, D., Patricio de Oliveira, D., Oliveira, M., Mansur, D.S., Irigoyen, N., Walczak, H. and Ferguson, B.J. (2023) LUBAC is required for RIG-I sensing of RNA viruses. Cell Death Differ. doi: 10.1038/s41418-023-01233-x.

A10 - Walczak - Abstract

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Simonis, A., Kreer. C., Albus, A., Rox, K., Yuan, B., Holzmann, D., Wilms, J.A., Zuber, S., Kottege, L., Winter, S., Meyer, M., Schmitt, K., Gruell, H., Theobald, S.J., Hellmann, A.M., Meyer, C., Ercanoglu, M.S., Cramer, N., Munder, A., Hallek, M., Fätkenheuer, G., Koch, M., Seifert, H., Rietschel, E., Marlovits, T.C., van Koningsbruggen-Rietschel, S., Klein, F., and Rybniker, J. (2023). Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa. Cell. 186, 5098-5113.e19. doi: 10.1016/j.cell.2023.10.002.

B05 - Rybniker - Abstract

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Sun, Z., Cernilogar, F.M., Horvatic, H., Yeroslaviz, A., Abdullah, Z., Schotta, G. and Hornung. V. (2023) β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4. Cell Rep. 42, 113322. doi: 10.1016/j.celrep.2023.113322. Epub ahead of print. PMID: 37883227.

A03 - Hornung - Abstract

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Llamas, E., Koyuncu, S., Lee, H.J., Wehrmann, M., Gutierrez-Garcia, R., Dunken, N., Charura, N., Torres-Montilla, S., Schlimgen, E., Mandel, A.M., Theile, E.B., Grossbach, J., Wagle, P., Lackmann, J.W., Schermer, B., Benzing, T., Beyer, A., Pulido, P., Rodriguez-Concepcion, M., Zuccaro, A. and Vilchez, D. (2023) In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat Aging. doi: 10.1038/s43587-023-00502-1

B03 - Zuccaro - Abstract

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Schorn, F., Werthenbach, J.P., Hoffmann, M., Daoud, M., Stachelscheid, J., Schiffmann, L.M., Hildebrandt, X., Lyu, S.I., Peltzer, N., Quaas, A., Vucic, D., Silke, J., Pasparakis, M. and Kashkar, H. (2023) cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. doi: 10.15252/embj.2023113614

B01 - Kashkar & A01 - Pasparakis - Abstract

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Czabotar, P.E. and Garcia-Saez, A.J. (2023) Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nat Rev Mol Cell Biol. doi: 10.1038/s41580-023-00629-4 (review)

A02 - García-Sáez - Abstract

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Grotehans, N., McGarry, L., Nolte, H., Xavier, V., Kroker, M., Narbona-Pérez, Á.J., Deshwal, S., Giavalisco, P., Langer, T. and MacVicar, T. (2023) Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. EMBO J. doi: 10.15252/embj.2022113256.

A06 - Langer - Abstract

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Rieger, J., Fitz, M., Fischer, S.M., Wallmeroth, N., Flores-Romero, H., Fischer, N.M., Brand, L.H., García-Sáez, A.J., Berendzen, K.W. and Mira-Rodado, V. (2023) Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods. Genes (Basel). doi: 10.3390/genes14081638

A02 - García-Sáez - Abstract

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Röck, B.F., Shalaby, R. and García-Sáez, A.J. (2023) Pyroptosis Induction and Visualization at the Single-Cell Level Using Optogenetics. Methods Mol Biol. 2696, 135-147. doi: 10.1007/978-1-0716-3350-2_10 (review)

A02 - García-Sáez - Abstract

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Cao, Y., Kümmel, F., Logemann, E., Gebauer, J.M., Lawson, A.W., Yu, D., Uthoff, M., Keller, B., Jirschitzka, J., Baumann, U., Tsuda, K., Chai, J. and Schulze-Lefert, P. (2023) Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2307604120

B08 - Schulze-Lefert & Chai - Abstract

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Injarabian, L., Willenborg, S., Welcker, D., Sanin, D.E., Pasparakis, M., Kashkar, H. and Eming, S.A. (2023) FADD- and RIPK3-mediated cell death ensures clearance of Ly6C^high wound macrophages from damaged tissue. J Invest Dermatol. doi: 10.1016/j.jid.2023.06.203.

A07 - Eming & B01 - Kashkar & A01 - Pasparakis - Abstract

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Martinez Lagunas, K., Savcigil, D.P., Zrilic, M., Carvajal Fraile, C., Craxton, A., Self, E., Uranga-Murillo, I., de Miguel, D., Arias, M., Willenborg, S., Piekarek, M., Albert, MC., Nugraha, K., Lisewski, I., Janakova, E., Igual, N., Tonnus, W., Hildebrandt, X., Ibrahim, M., Ballegeer, M., Saelens, X., Kueh, A., Meier, P., Linkermann, A., Pardo, J., Eming, S., Walczak, H., MacFarlane, M., Peltzer, N., Annibaldi, A. (2023) Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair. Sci Adv. doi: 10.1126/sciadv.adg2829

A07 - Eming & A10 - Peltzer & Walczak & Assoc. Annibaldi - Abstract

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Crean, E.E., Bilstein-Schloemer, M., Maekawa, T., Schulze-Lefert, P. and Saur, I.M.L. (2023) A dominant-negative avirulence effector of the barley powdery mildew fungus provides mechanistic insight to barley MLA immune receptor activation. J Exp Bot. doi: 10.1093/jxb/erad285

B08 - Schulze-Lefert & B07 - Maekawa - Abstract

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Pedrera, L., Ros, U. and García-Sáez, A.J. (2023) Calcium as a master regulator of ferroptosis and other types of regulated necrosis. Cell Calcuim 114, 102778 . doi: https://doi.org/10.1016/j.ceca.2023.102778

A02 - García-Sáez - Abstract

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Barghahn, S., Saridis, G., Mantz, M., Meyer, U., Mellüh, J.C., Misas Villamil, J.C., Huesgen, P.F. and Doehlemann, G. (2023) Combination of transcriptomic, proteomic and degradomic profiling reveals common and distinct patterns of pathogen-induced cell death in maize. Plant J. doi: 10.1111/tpj.16356.

B02 - Döhlemann & Huesgen - Abstract

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Koenig, M., Moser, D., Leusner, J., Depotter, J., Doehlemann, G. and Misas Villamil, J.C. (2023) Maize phytocytokines modulate pro-survival host responses and pathogen resistance. Mol Plant Microbe Interact. doi: 10.1094/MPMI-01-23-0005-R.

B02 - Döhlemann - Abstract

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Augustin, M., Heyn, F., Ullrich, S., Sandaradura de Silva U, Albert MC, Linne V, Schlotz M, Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fätkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald S.J., and Lehmann C. (2023) Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome. Front Med (Lausanne). 10, 1129288. doi: 10.3389/fmed.2023.1129288

B05 - Rybniker and A10 Walczak - Abstract

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Feehan, J.M., Wang, J., Sun, X., Choi, J., Ahn, H.K., Ngou, B.P.M., Parker, J.E., Jones, and J.D.G. (2023). Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation. Proc Natl Acad Sci U S A. 120, e2210406120. doi: 10.1073/pnas.2210406120.

B08 - Parker - Abstract

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Hadrian, K., Musial, G., Schönberg, A., Georgiev, T., Küper, C., Bock, F., Jantsch, J., Cursiefen, C., Eming, S.A., and Hos, D. (2023). The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury. Exp Mol Med. 55, 565-573. doi: 10.1038/s12276-023-00954-w.

A07 - Eming - Abstract

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Müller, F., Lim, J.K.M., Bebber, C.M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F.I., Nakayama, K., Torres Fernández, L., Brägelmann, J., Leprivier, G., and von Karstedt, S. (2023. Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Cell Death Differ 30, 442-456. doi: 10.1038/s41418-022-01096-8.

A05 - von Karstedt - Abstract

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Shalaby, R., Diwan, A., Flores-Romero, H., Hertlein, V., and Garcia Saez, A.J. (2023). Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation. Cell Death Differ 30, 731–741 https://doi.org/10.1038/s41418-022-01078-w

A02 - Garcia Saez - Abstract

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Demir, F., Perrar, A., Mantz, M., and Hiesgen, P.F., (2023). Sensitive Plant N-Terminome Profiling with HUNTER. Method Mol Biol. 2447. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2079-3_12

B02 - Huesgen - Abstract

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Di Benedetto, C., Khan, T., Serrano-Saenz, S., Rodriguez-Lemus, A., Klomsiri, C., Beutel, T.-M., Thach, A., Walczak, H., and Betancur, P. (2023). Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis. Cancers 15, 967. https://doi.org/10.3390/cancers15030967

A10 - Walczak - Abstract

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Deshwal, S., Onishi, M., Tatsuta, T., Bartsch, T., Cors, E., Ried, K., Lemke, L., Nolte, H., Giavalisco, P. and Langer, T. (2023). Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-022-01071-y

A06 - Langer - Abstract

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Johanndrees, O., Baggs, E.L., Uhlmann, C., Locci, F., Läßle, H.L., Melkonian, K., Käufer, K., Dongus, J.A., Nakagami, H., Krasileva, K.V., Parker, J.E., and Lapin, D. (2023). Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1  Plant Physiology, Volume 191, Issue 1, January 2023, Pages 626–642, https://doi.org/10.1093/plphys/kiac480

B08 - Parker - Abstract

Pinci, F., Gaidt, M.M., Jung, C., Nagl, D., Kuut, G., Hornung, V. (2022) Tumor necrosis factor is a necroptosis-associated alarmin. Front. Immunol. 13:1074440. doi: 10.3389/fimmu.2022.1074440

A03 - Hornung - Abstract

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Kieckhöfer, E., Slaats, G.G., Ebert, L.K., Albert, M.-C., Dafinger, C., Kashkar, H., Benzing, T. & Schermer, B. (2022) Primary cilia suppress Ripk3-mediated necroptosis. Cell Death Discovery  8, Article number: 477 (2022) https://doi.org/10.1038/s41420-022-01272-2

A09 - Schermer & Benzing, B01 - Kashkar - Abstract

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Seidel, E., & von Karstedt, S. (2022) Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? Cell Death and Differentiation 8, Article number: 465 (review)

A05 - von Karstedt - Abstract

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Schmacke, N.A., O'Duill, F., Gaidt, M.M., Szymanska, I., Kamper, J.M., Schmid-Burgk, J.L., Mädler, S.C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C.A., Harz, H., Fröhlich, A.L.. Pinci, F., Ginhoux, F.L., Beckmann, R., Mann, M., Leonhardt, H., Hornung, V. (2022) IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity 2022 Nov 9;S1074-7613(22)00562-3. doi: 10.1016/j.immuni.2022.10.021.

A03 - Hornung - Abstract

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Wang,J., Song, W., Chai, J. (2022) Structure, biochemical function and signaling mechanism of plant NLRs. Molecular Plant https://doi.org/10.1016/j.molp.2022.11.011 (review)

B08 - Chai - Abstract

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Ahola, S., Rivera Mejías, P., Hermans, S., Chandragiri, S., Giavalisco, P., Nolte, H., Langer, T. (2022) OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metabolism Vol 34, Issue 11, 1.11.22 pages 17845-1891.e7 https://doi.org/10.1016/j.cmet.2022.08.017

A06 - Langer - Abstract

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Kožich, V., Schwahn, B.C., Sokolová, J., Křížková, M., Ditroi, T., Krijtm J., Khalil, Y., Křížek. T., Vaculíková-Fantlová, T., Stibůrková, B., Milla, P., Clayton, P., Barvíková, K., Blessing, H., Sykut-Cegielska, J., Dionisi-Vici, C., Gasperini, A., García-Cazorla, A., Haack, T.B., Honzík, T., Ješina, P., Kuster, A., Laugwitz, L., Martinelli, D., Porta, F., Santer, R., Schwarz, G., Nagy, P. (2022) Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H₂S homeostasis. Redox Biology 58 (2022) 102517 https://doi.org/10.1016/j.redox.2022.102517

A08 - Schwarz - Abstract

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Montinaro, A. & Walczak, H. (2022) Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01059-z (review)

A10 - Walczak - Abstract

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Jenster, L-M, Lange, K-E, Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers,
L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., Ebner, S., Lapp, D.J., Mayer, J., Moecking, J., Ploegh, H.D. Latz, E., Meissner, F., Geyer, M., Kümmerer, B.M. and Schmidt, F.I., P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J. Exp. Med. 2023 Vol. 220 No. 1 e20220837 https://doi.org/10.1084/jem.20220837

A04 - Latz & Schmidt - Abstract

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Maekawa, T., Kashkar, H. & Coll, N.S. Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01060-6 (review)

B01 - Kashkar & B07 - Maekawa - Abstract

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Akbal, A., Dernst, A., Lovotti, M., Mangan, M.S.J., McManus, R.M., & Latz, E. How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol (2022). https://doi.org/10.1038/s41423-022-00922-w (review)

A04 - Latz - Abstract

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Stafford, C.A., Gassauer, A.-M., de Oliveira Mann, C.C., Tanzer, M.C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S.J., Wiest, A., Pfautsch, M.K., Wurst, W., Yabal, M., Fröhlich, T., Mann, M., Gisch, N., Jae, L.T., & Hornung, V. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.  Nature 609, 590–596 (2022). https://doi.org/10.1038/s41586-022-05125-x

A03 - Hornung - Abstract

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Sun, Y., Wang, Y., Zhang, X., Chen, Z., Xia, Y., Wang, L., Sun, Y., Zhang, M., Xiao, Y., Han, Z., Wang, Y., & Chai, J. Plant receptor-like protein activation by a microbial glycoside hydrolase. Nature (2022). https://doi.org/10.1038/s41586-022-05214-x

B08 - Chai - Abstract

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Hildebrandt, X., Ibrahim, M. & Peltzer, N. Cell death and inflammation during obesity: “Know my methods, WAT(son)”. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01062-4 (review)

A10 - Peltzer - Abstract

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Förderer, A., Li, E., Lawson, A.W., Deng, Y., Sun, Y., Logemann, E., Zhang, X., Wen, J., Han, Z., Chang, J., Chen, Y., Schulze-Lefert, P., & Chai, J. A wheat resistosome defines common principles of immune receptor channels. Nature (2022) https://doi.org/10.1038/s41586-022-05231-w

B08 - Chai & Schulze-Lefert - Abstract

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Jiao, H., Wachsmuth, L., Wolf, S., Lohmann, J., Nagata, M., Kaya, G. G., Oikonomou, N., Kondylis, V., Rogg, M., Diebold, M., Tröder, S.E., Zevnik, B., Prinz, M., Schell, C., Young, G.R., Kassiotis, G: & Pasparakis, M. (2022) ADAR1 averts fatal type I interferon induction by ZBP1. Nature (2022). https://doi.org/10.1038/s41586-022-04878-9

A01 - Pasparakis - Abstract

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Huang S., Jia, A., Song, W., Hessler, G., Meng, Y., Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Ma, S., Xiao, Y., Yu, D., Hou, J., Liu, R., Sun, H., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science DOI: 10.1126/science.abq3297

B08 - Chai & Parker - Abstract

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Jia, A., Huang, S,. Song, W., Wang, J., Meng, Y,. Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Hou, J., Zhang, T., Yu, W., Hessler, G., Li, E., Ma, S., Yu, D., Gebauer, J., Baumann, U., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 10.1126/science.abq8180

B08 - Chai & Parker - Abstract

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Theobald, S.J., Simonis, A., Mudler, J.M., Göbel, U., Acton, R., Kohlhas, V., Albert, M.-C., Hellmann, A.-M., Malin, J.J., Winter, S., Hallek, M., Walczak, H., Nguyen, P.-H., Koch, M., Rybniker, J. (2022) Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med e15888 https://doi.org/10.15252/emmm.202215888

B05 - Rybniker & A10 - Walczak - Abstract

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Peltzer, N., & Annibaldi, A., (2022) Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. Biomedicines 10(6): 1436 doi: 10.3390/biomedicines10061436 (review)

A10 - Peltzer & Assoc. Annibaldi - Abstract

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Xu, L., Wang, J., Xiao, Y., Han, Z., Chai, J. (2022) Structural insight into chitin perceptionby chitin elicitor receptor kinase 1 of Oryza sativa. J Integr Plant Biol. 2022 May 14. doi: 10.1111/jipb.13279.

B07 - Chai - Abstract

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Li, X., Huang, C.-H., Sánchez-Rivera, F.J., Kennedy, M.C., Tschaharganeh, D.F., Morris IV, J.P., Montinaro, A., O'Rourke, K.P., Banito, A, Wilkinson, J.E., Chen, C.-C., Ho, Y.-J., Dow, L.E., Tian, S., Luan, W., de Stanchina, E., Zhang, T., Gray, N.S., Walczak, H., Lowe, S.W. (2022) A preclinical platform for assessing antitumor effects andsystemic toxicities of cancer drug targets. PNAS 2022 Vol. 119 No. 17 e2110557119 https://doi.org/10.1073/pnas.2110557119

A10 - Walczak - Abstract

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Sanin, D.E., Ge, Y., Marinkovic, E., Kabat, A.M., Castoldi, A., Caputa, G., Grzes, K.M., Curtis, J.D., Thompson, E.A., Willenborg, S., Dichtl, S., Reinhardt, S., Dahl, A., Pearce, E.L., Eming, S.A., Gerbaulet, A., Roers, A., Murray, P.J., Pearce, E.J. (2022) A common framework of monocyte-derived macrophage activation Science Immunology 7, eabl7482 DOI: 10.1126/sciimmunol.abl7482

A07 - Eming - Abstract

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Daoud, M., Broxtermann, P.N., Schorn, F., Werthenbach, J.P., Seeger, J.M., Schiffmann, L.M., Brinkmann, K., Vucic, D., Tüting, T., Mauch, C., Kulms, D., Zigrino, P., Kashkar, H. (2022) XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. EMBO Reports (2022)e53608 https://doi.org/10.15252/embr.202153608

B01 - Kashkar - Abstract

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Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., Miethe, S., Elling, U., Schermer, B., Baumann, U., Denzel, M.S, (2022) GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. eLife 2022;11:e69223 doi: 10.7554/eLife.69223

A09 - Schermer - Abstract

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Peltzer, N. (2022) Linear ubiquitin as a common regulator of cellular stress. FEBS Journal 2022 https://doi.org/10.1111/febs.16425 (review)

A10 - Peltzer - Abstract

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Lapin, D., Johanndrees, O., Wu, Z., Parker, J.E. (2022) Molecular innovations in plant TIR-based immunity signaling. The Plant Cell 2022: 00: 1-18 https://doi.org/10.1093/plcell/koac035

B08 - Parker - Abstract

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Simpson, D.S., Pang, J., Weir, A., Kong, I.Y., Fritsch, M., Rashidi, M., Cooney, J.P., Davidson, K.C., Speir, M., Djajawi, T.M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A.S., Conos, S.A., Tye, H., Chow, S.H.,  Rahman, A., Norton, R.S., Naderer, T., Nicholson, S.E., Burgio, G., Man, S.M., Groom, J.R,. Herold, M.J., Hawkins, E.D., Lawlor, K.E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R., Vince, J.E. (2022) Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55, 1–19, March 8, 2022 https://doi.org/10.1016/j.immuni.2022.01.003

B01 - Kashkar - Abstract

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Cosentino, K., Hertlein, V., Jenner, A., Dellmann, T., Gojkovic, M., Peña-Blanco, A., Dadsena, S., Wajngarten, N., Danial, J.S.H., Thevathasan, J.V., Mund, M., Ries, J., Garcia-Saez, A.J. (2022) The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular Cell 82, 1-17, February 17, 2022 https://doi.org/10.1016/j.molcel.2022.01.008

A02 - Garcia - Abstract

Parker, J.E., Hessler, G., Cui, H. (2021) A new biochemistry connecting pathogen detection to induced defense in plants. New Phytologist https://doi.org/10.1111/nph.17924

B08 - Parker - Abstract

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Christ, A., Latz, E. (2021) Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis. Circulation Research 2021;129:840–842 https://doi.org/10.1161/CIRCRESAHA.121.320131

A04 - Latz - Abstract

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Flores-Romero, H., Hohorst, L., John, M., Albert, M.-C., King, L.E., Beckmann, L., Szabo, T., Hertlein, V., Luo, X., Villunger, A., Frenzel, L.P., Kashkar, H., & Garcia-Saez, A.J. (2021) BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO Journal (2021) e108690 DOI10.15252/embj.2021108690

A02 - Garcia-Saez & B01 Kashkar - Abstract

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Tanzer, M.C., Bludau, I., Stafford, C.A., Hornung, V., & Mann, M. (2021) Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling. Nature Communications 2021 12:6053, https://doi.org/10.1038/s41467-021-26289-6

A03 - Hornung - Abstract

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Kaczmarek, A.T., Bender, D., Gehling, T., Kohl, J.B., Daimagüler, H.S., Santamaria-Araujo, J.A., Liebau, M.C., Koy, A., Cirak, S., Schwarz, G. (2021) A defect in molybdenum cofactor binding causes an attenuated form of sulfite oxidase deficiency. JMD https://doi.org/10.1002/jimd.12454

A08 - Schwarz - Abstract

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Willenborg, S., Sanin, D.E., Jais, A., Ding, X.,Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021) Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism 33,1–17 December 7, 2021. https://doi.org/10.1016/j.cmet.2021.10.004

A07 - Eming & A06 - Langer - Abstract

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Theobald, S.J., Gräb, J., Fritsch, M., Suárez, I., Eisfeld, H.S., Winter, S., Koch, M., Hölscher, C., Pasparakis, M., Kashkar, H., and Rybniker, J. (2021) Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov. 7, 327 (2021). https://doi.org/10.1038/s41420-021-00716-5

B05 - Rybniker & B01 - Kashkar & A01 - Pasparakis - Abstract

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Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M.,  Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J.U.G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., Sauve, F., Coêlho, C.F.F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P.,  Busch, H., Collin, L.,  Villaseñor, R., Jöhren, O., Altmeppen, H.C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V., & Schwaninger, M. (2021) The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. https://doi.org/10.1038/s41593-021-00926-1

A01 - Pasparakis

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Eisfeld, H.S., Simonis, A., Winter, S., Chhen, J., Ströh, L.J., Krey, T., Koch, M., Theobald, S.J., Rybniker, J. (2021). Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages. Viruses 2021, 13, 2076. https://doi.org/10.3390/v13102076

B05 - Rybniker - Abstract

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Schünke, H., Göbel, U., Dikic, I., Pasparakis, M. (2021). OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nature Communications 12, Article Number: 5912 https://doi.org/10.1038/s41467-021-25945-1

A01 - Pasparakis - Abstract

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Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A-L-, Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke J. & Walczak, H. (2021) Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differentiation. https://doi.org/10.1038/s41418-021-00869-x

A10 - Waczak & A05 - von Karstedt - Abstract

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Pruitt, R.N., Locci, F., Wanke, F., Zhang, L., Saile, S.C., Joe, A., Karelina, D., Hua, C., Fröhlich, K., Wan, W.-L., Hu, M., Rao, S., Stolze, S.C., Harzen, A., Gust, A.A., Harter, K., Joosten, M.H.A.J., Thomma, B.P.H.J., Zhou, J.-M., Dangl, J.L., Weigel, D., Nakagami, H., Oecking, C., El Kasmi, F., Parker, J.E., & Nürnberger, T. (2021) The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity. Nature. https://doi.org/10.1038/s41586-021-03829-0

B08 - Parker - Abstract

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Bahat, A., MacVicar, T., and Langer, T. (2021) Metabolism and Innate Immunity Meet at the Mitochondria. Frontiers in Cell and Developmental Biology 2021; 9: 720490. doi: 10.3389/fcell.2021.720490

A06 - Langer - Abstract

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Jain, R., Zhao, K., Sheridan, J.M. Heinlein, M., Kupresanin, F., Abeysekera, W., Hall, C., Rickard, J., Bouillet, P., Walczak, H., Strasser, A., Silke, J. & Gray, D.H.D. (2021). Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death & Differentiation. https://doi.org/10.1038/s41418-021-00850-8

A10 - Walczak - Abstract

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Budden, C.F., Gearing, L.J., Kaiser, R., Standke, L., Hertzog, P J., & Latz, E. (2021). Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses. Journal of Extracellular Vesicles 10, e12127. https://doi.org/10.1002/jev2.1212

A04 - Latz - Abstract

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Geueke, A., Mantellato, G., Kueste, F., Schettina, P., Nelles, M., Seeger, J.M., Kashkar, H., & Niemann, C. (2021) The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBO reports e52301 https://doi.org/10.15252/embr.202052301

B01 - Kashkar - Abstract

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Llamas, E., Torres-Montilla, S., Lee, H. J., Barja, M. V., Schlimgen, E., Dunken, N., Wagle, P., Werr, W., Zuccaro, A., Rodríguez-Concepción, M., & Vilchez, D (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell, 00, e13446. https://doi.org/10.1111/acel.13446

B03 - Zuccaro - Abstract

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Hepowit, N.L., Kolbe, C.-C., Zelle, S.R., Latz, E., MacGurn, J.A. (2021) Regulation of Ubiquitin and Ubiquitin-like Modifiers by Phosphorylation. The FEBS Journal 02 July 2021https://doi.org/10.1111/febs.16101

A04 - Latz

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Sun, X., Lapin, D., Feehan, J.M., Stolze, S.C., Kramer, K., Dongus, J.A., Rzemieniewski, J., Blanvillain-Baufumé, S., Harzen, A., Bautor, J., Derbyshire, P., Menke, F.L.H., Finkemeier, I., Nakagami, H., Jones, J.D.G., & Parker, J.E.(2021) Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature Communications 12, Article number: 3335 https://doi.org/10.1038/s41467-021-23614-x

B08 - Parker - Abstract

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Alvarez, C.R., Kee, C., Sharma, A.,K., Thomas, L., Schmidt, F.I., Stanifer, M.L., Boulant, S., Herrmann, C. (2021) The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLOS Pathogens June 28, 2021 https://doi.org/10.1371/journal.ppat.1009687

A04 - Schmidt - Abstract

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Theobald, S.J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H.S., Albert, M.C., Chhen, J., Motameny, S., Erger, F., Fischer, J., Malin, J.J., Gräb, J., Winter, S., Pouikli, A., David, F., Böll, B., Koehler, P., Vanshylla, K., Gruell, H., Suárez, I., Hallek, M., Fätkenheuer, G., Jung, N., Cornely, O.A., Lehmann, C., Tessarz, P., Altmüller, J., Nürnberg, P., Kashkar, H., Klein, F., Koch, M., and Rybniker, J. (2021) Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med e14150https://doi.org/10.15252/emmm.202114150

B05 - Rybniker & B01 - Kashkar - Abstract

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Oikonomou, N., Schuijs, M.J., Chatzigiagkos, A., Androulidaki, A., Aidinis, V., Hammad, H., Lambrecht, B.N., and Pasparakis, M. (2021) Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunology https://doi.org/10.1038/s41385-021-00415-5

A01 - Pasparakis - Abstract

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Hadrian, K., Willenborg, S., Bock, F., Cursiefen, C., Eming, S.A., and Hos, D. (2021). Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin. Front. Immunol., 07 April 2021 | https://doi.org/10.3389/fimmu.2021.667830

A07 - Eming - Abstract

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Sprenger, H.G., MacVicar, T., Bahat, A., Fiedler, K.U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N., Larsson, N.G., Nolte, H., Giavalisco, P. & Langer. T. (2021) Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity. Nature Metabolism 26.04.2021 https://doi.org/10.1038/s42255-021-00385-9

A06 - Langer - Abstract

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Kumari, S., Van, T.-M., Preukschat, D., Schuenke, H., Basic, M., Bleich, A., Klein, U., Pasparakis, M. (2021) NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life Science Alliance 15 April 2021. DOI: 10.26508/lsa.202000956

A01 - Pasparakis - Abstract

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Bebber, C.M., Thomas, E.S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M.N., Stüker, L., de Pádua Alves,C., Khonsari, A., Dammert, M.A., Parmaksiz, F., Tumbrink, H.L., Beleggia, F., Sos, M.L., Riemer, J., George, J., Brodesser, S., Thomas, R.K., Reinhardt, H.C. & von Karstedt, S. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications volume 12, Article number: 2048. https://doi.org/10.1038/s41467-021-22336-4

A05 - von Karstedt - Abstract

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Bauernfried. S., & Hornung, V. (2021) DPP9 restrains NLRP1 activation. Nat Struct Mol Biol. https://doi.org/10.1038/s41594-021-00580-y

A03 - Hornung - Abstract

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Xing, Y., Xu, N., Bhandari, D.,D., Lapin, D., Sun, X., Luo, X., Wang, Y., Cao, J., Wang, H., Coaker, G., Parker, J.,E., Liu, J. Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. The Plant Cell Koab075 https://doi.org/10.1093/plcell/koab075

B08 - Parker - Abstract

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Mooney, B. C., Mantz, M., Graciet, E, Huesgen, P. F. (2021) Cutting the line: manipulation of plant immunity by bacterial type III effector proteases. J Exp Bot doi:10.1093/jxb/erab095

B02 - Huesgen - Abstract

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Zhao, C., Tang, Y., Wang. J., Zeng, Y., Sun, H., Zheng, Z., Su, R., Schneeberger, K., Parker, J.E., Cui, H. (2021) A mis‐regulated cyclic nucleotide‐gated channel mediates cytosolic calcium elevation and activates immunity in Arabidopsis. New Phytologist doi:10.1111/nph.17218

B08 - Parker - Abstract

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Bauer, S., Yu, D., Lawson, A.W., Saur, I.M.L., Frantzeskakis, L., Kracher, B., Logemann, E., Chai, J., Maekawa, T., Schulze-Lefert, P. (2021) The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold. PLoS Pathog 17(2): e1009223. doi:10.1371/journal.ppat.1009223

B08 - Schulze-Lefert & Maekawa & Chai - Abstract

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Koenig,P.-A., Das, H., Liu, H., Kümmerer, B. M., Gohr, F. N., Jenster, L.-N., Schiffelers, L. D. J., Tesfamariam, Y. M., Uchima, M., Wuerth, J. D., Gatterdam, K., Ruetalo, N., Christensen, M., H., Fandrey, C. I., Normann, S., Tödtmann, J. M. P., Pritzl, S., Hanke, L., Boos, J., Yuan, M., Zhu, X., Schmid-Burgk, J.-L., Kato, H., Schindler, M., Wilson, I. A., Geyer, M., Ludwig, K. U., Hällberg, B. M., Wu, N. C., Schmidt, F. I. (2021) Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science 2021 Jan 12:eabe6230. doi: 10.1126/

A04 - Schmidt - Abstract

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Mellis, A-T., Misko, A.L., Arjune, S., Liang, Y., Erdélyi, K., Ditrói, T., Kaczmarek, A.T., Nagy, P., Schwarz, G. (2021) The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism. Redox Biology Volume 38 2021, https://doi.org/10.1016/j.redox.2020.101800

A08 - Schwarz - Abstract

Pinci, F., Gaidt, M. M., Jung,C., Kuut, G., Jackson, M. A., Bauernfried, S., and  Hornung, V. (2020) C-tag TNF: a reporter system to study TNF shedding. Journal of Biological Chemistry Vol 295, Issue 52. DOI 10.1074/jbc.RA120.015248

A03 - Hornung - Read more

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Pedrera, L., Espiritu, R., A., Ros, U., Weber, J., Schmitt, A., Stroh, J., Hailfinger, S., von Karstedt, S., García-Sáez, A., J. (2020) Ferroptotic pores induce Ca 2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ Dec 17. doi: 10.1038/s41418-020-00691-x

A02 - Garcia-Saez - Read more

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Ma, S., Lapin, D., Liu, L., Sun, Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P., Parker, J.E., Chai, J. (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science Vol. 370, Issue 6521, eabe3069; https://doi.org/10.1126/science.abe3069

B08 - Chai, Parker and Schulze Lefert - Read more

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Flores‐Romero, H., Ros, U., Garcia-Saez, A.J. (2020) Pore formation in regulated cell death. EMBO J (2020)e105753 https://doi.org/10.15252/embj.2020105753

A02 - Garcia-Saez - Read more

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Clemente, L.P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J., Culmsee, C., von Karstedt, S. (2020) Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells Oct 9;9(10):E2259. doi: 10.3390/cells9102259

A05 - von Karstedt - Read more

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Mahdi, L.K., Huang, M., Zhang, X., Nakano, R.T., Kopp, L.B., Saur, I.M.L., Jacob, F., Kovacova, V., Lapin, D., Parker, J.E., Murphy, J.M., Hofmann, K., Schulze-Lefert, P., Chai, J., Maekawa, T. (2020) Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling. Cell Host & Microbe https://doi.org/10.1016/j.chom.2020.08.012

B07 - Maekawa, Chai & B08 - Schulze-Lefert & B06 Hofmann  - Read more

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Mayer, C.T., Nieke, J.P., Gazumyan, A., Cipolla, M., Wang, Q., Oliveira, Y.T., Ramos, V., Monette, S., Li, Q.Z., Gershwin, M.E., Kashkar, H., Nussenzweig, M.C. (2020) An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells. Proc Natl Acad Sci U S A [Epub ahead of print] https://doi.org/10.1073/pnas.2015372117

B01 - Kashkar - Read more

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Albert, M.C., Brinkmann, K., Pokrzywa, W., Günther, S.D., Krönke, M., Hoppe, T. & Kashkar, H. (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis 11, 740. https://doi.org/10.1038/s41419-020-02923-x

B01 - Kashkar - Read more

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Schiffmann, L.M., Werthenbach, J.P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S.D., Willenborg,S., Brodesser,S., Lucas, C. Jüngst, C., Albert, M.C., Schorn, F.,Witt, A., Moraes, C.T., Bruns, C.J., Pasparakis, M., Krönke, M., Eming, S.A., Coutelle, O., Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Comm. Volume 11, Article Number: 3653. https://doi.org/10.1038/s41467-020-17472-2

B01 - Kashkar & A07 - Eming & A01 - Pasparakis - Read more

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Laurien, L., Nagata, M., Schünke, H., Delanghe, T., Wiederstein, J., L.,  Kumari, S., Schwarzer, R., Corona, T., Krüger, M., Bertrand, M., J., M., Kondylis, V. & Pasparakis, M.(2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat. Comm. Volume 11, Article number: 1747. https://doi.org/10.1038/s41467-020-15466-8

A01 - Pasparakis - Read more.

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Schwarzer, R., Jiao, H., Wachsmuth, L., Tresch, A., Pasparakis, M.(2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity Volume 52, Pages 1-16. https://doi.org/10.1016/j.immuni.2020.04.002 For free acces please go here

A01 - Pasparakis - Read more.

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Schwarzer, R., Laurien, L., Pasparakis, M. (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Curr. Opin. Cell Biol. Volume 63, Pages 186-193. https://doi.org/10.1016/j.ceb.2020.02.004

A01 - Pasparakis - Read more.

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Jiao, H., Wachsmuth, L., Kumari, S., Schwarzer, R., Lin, J., Eren, R., O., Fisher, A., Lane, R., Young, G., R.,  Kassiotis, G., Kaiser W., J., Pasparakis, M. (2020). Z-nucleic-acid sensing triggers ZBP1dependent necroptosis and inflammation. Nature, https://doi.org/10.1038/s41586-020-2129-8

A01 - Pasparakis - Read more.

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Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H. (2020) Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat. Microbiol. 5:354–367.

B01 - Kashkar & A03 - Hornung - Read more