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Recent Publications 2022

Ahola, S., Rivera Mejías, P., Hermans, S., Chandragiri, S., Giavalisco, P., Nolte, H., Langer, T. (2022) OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metabolism Vol 34, Issue 11, 1.11.22 pages 17845-1891.e7 https://doi.org/10.1016/j.cmet.2022.08.017

A06 - Langer - Abstract


Kožich, V., Schwahn, B.C., Sokolová, J., Křížková, M., Ditroi, T., Krijtm J., Khalil, Y., Křížek. T., Vaculíková-Fantlová, T., Stibůrková, B., Milla, P., Clayton, P., Barvíková, K., Blessing, H., Sykut-Cegielska, J., Dionisi-Vici, C., Gasperini, A., García-Cazorla, A., Haack, T.B., Honzík, T., Ješina, P., Kuster, A., Laugwitz, L., Martinelli, D., Porta, F., Santer, R., Schwarz, G., Nagy, P. (2022) Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis. Redox Biology 58 (2022) 102517 https://doi.org/10.1016/j.redox.2022.102517

A08 - Schwarz - Abstract


Montinaro, A. & Walczak, H. (2022) Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01059-z (review)

A10 - Walczak - Abstract


Jenster, L-M, Lange, K-E, Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers,
L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., Ebner, S., Lapp, D.J., Mayer, J., Moecking, J., Ploegh, H.D. Latz, E., Meissner, F., Geyer, M., Kümmerer, B.M. and Schmidt, F.I., P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J. Exp. Med. 2023 Vol. 220 No. 1 e20220837 https://doi.org/10.1084/jem.20220837

A04 - Latz & Schmidt - Abstract


Maekawa, T., Kashkar, H. & Coll, N.S. Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01060-6 (review)

B01 - Kashkar & B07 - Maekawa - Abstract


Akbal, A., Dernst, A., Lovotti, M., Mangan, M.S.J., McManus, R.M., & Latz, E. How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol (2022). https://doi.org/10.1038/s41423-022-00922-w (review)

A04 - Latz - Abstract


Stafford, C.A., Gassauer, A.-M., de Oliveira Mann, C.C., Tanzer, M.C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S.J., Wiest, A., Pfautsch, M.K., Wurst, W., Yabal, M., Fröhlich, T., Mann, M., Gisch, N., Jae, L.T., & Hornung, V. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation.  Nature 609, 590–596 (2022). https://doi.org/10.1038/s41586-022-05125-x

A03 - Hornung - Abstract


Sun, Y., Wang, Y., Zhang, X., Chen, Z., Xia, Y., Wang, L., Sun, Y., Zhang, M., Xiao, Y., Han, Z., Wang, Y., & Chai, J. Plant receptor-like protein activation by a microbial glycoside hydrolase. Nature (2022). https://doi.org/10.1038/s41586-022-05214-x

B08 - Chai - Abstract


Hildebrandt, X., Ibrahim, M. & Peltzer, N. Cell death and inflammation during obesity: “Know my methods, WAT(son)”. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01062-4 (review)

A10 - Peltzer - Abstract


Förderer, A., Li, E., Lawson, A.W., Deng, Y., Sun, Y., Logemann, E., Zhang, X., Wen, J., Han, Z., Chang, J., Chen, Y., Schulze-Lefert, P., & Chai, J. A wheat resistosome defines common principles of immune receptor channels. Nature (2022) https://doi.org/10.1038/s41586-022-05231-w

B08 - Chai & Schulze-Lefert - Abstract


Jiao, H., Wachsmuth, L., Wolf, S., Lohmann, J., Nagata, M., Kaya, G. G., Oikonomou, N., Kondylis, V., Rogg, M., Diebold, M., Tröder, S.E., Zevnik, B., Prinz, M., Schell, C., Young, G.R., Kassiotis, G: & Pasparakis, M. (2022) ADAR1 averts fatal type I interferon induction by ZBP1. Nature (2022). https://doi.org/10.1038/s41586-022-04878-9

A01 - Pasparakis - Abstract


Huang S., Jia, A., Song, W., Hessler, G., Meng, Y., Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Ma, S., Xiao, Y., Yu, D., Hou, J., Liu, R., Sun, H., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science DOI: 10.1126/science.abq3297

B08 - Chai & Parker - Abstract


Jia, A., Huang, S,. Song, W., Wang, J., Meng, Y,. Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Hou, J., Zhang, T., Yu, W., Hessler, G., Li, E., Ma, S., Yu, D., Gebauer, J., Baumann, U., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 10.1126/science.abq8180

B08 - Chai & Parker - Abstract


Theobald, S.J., Simonis, A., Mudler, J.M., Göbel, U., Acton, R., Kohlhas, V., Albert, M.-C., Hellmann, A.-M., Malin, J.J., Winter, S., Hallek, M., Walczak, H., Nguyen, P.-H., Koch, M., Rybniker, J. (2022) Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med e15888 https://doi.org/10.15252/emmm.202215888

B05 - Rybniker & A10 - Walczak - Abstract


Peltzer, N., & Annibaldi, A., (2022) Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. Biomedicines 10(6): 1436 doi: 10.3390/biomedicines10061436 (review)

A10 - Peltzer & Assoc. Annibaldi - Abstract


Xu, L., Wang, J., Xiao, Y., Han, Z., Chai, J. (2022) Structural insight into chitin perceptionby chitin elicitor receptor kinase 1 of Oryza sativa. J Integr Plant Biol. 2022 May 14. doi: 10.1111/jipb.13279.

B07 - Chai - Abstract


Li, X., Huang, C.-H., Sánchez-Rivera, F.J., Kennedy, M.C., Tschaharganeh, D.F., Morris IV, J.P., Montinaro, A., O'Rourke, K.P., Banito, A, Wilkinson, J.E., Chen, C.-C., Ho, Y.-J., Dow, L.E., Tian, S., Luan, W., de Stanchina, E., Zhang, T., Gray, N.S., Walczak, H., Lowe, S.W. (2022) A preclinical platform for assessing antitumor effects andsystemic toxicities of cancer drug targets. PNAS 2022 Vol. 119 No. 17 e2110557119 https://doi.org/10.1073/pnas.2110557119

A10 - Walczak - Abstract


Sanin, D.E., Ge, Y., Marinkovic, E., Kabat, A.M., Castoldi, A., Caputa, G., Grzes, K.M., Curtis, J.D., Thompson, E.A., Willenborg, S., Dichtl, S., Reinhardt, S., Dahl, A., Pearce, E.L., Eming, S.A., Gerbaulet, A., Roers, A., Murray, P.J., Pearce, E.J. (2022) A common framework of monocyte-derived macrophage activation Science Immunology 7, eabl7482 DOI: 10.1126/sciimmunol.abl7482

A07 - Eming - Abstract


Daoud, M., Broxtermann, P.N., Schorn, F., Werthenbach, J.P., Seeger, J.M., Schiffmann, L.M., Brinkmann, K., Vucic, D., Tüting, T., Mauch, C., Kulms, D., Zigrino, P., Kashkar, H. (2022) XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. EMBO Reports (2022)e53608 https://doi.org/10.15252/embr.202153608

B01 - Kashkar - Abstract


Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., Miethe, S., Elling, U., Schermer, B., Baumann, U., Denzel, M.S, (2022) GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. eLife 2022;11:e69223 doi: 10.7554/eLife.69223

A09 - Schermer - Abstract


Peltzer, N. (2022) Linear ubiquitin as a common regulator of cellular stress. FEBS Journal 2022 https://doi.org/10.1111/febs.16425 (review)

A10 - Peltzer - Abstract


Lapin, D., Johanndrees, O., Wu, Z., Parker, J.E. (2022) Molecular innovations in plant TIR-based immunity signaling. The Plant Cell 2022: 00: 1-18 https://doi.org/10.1093/plcell/koac035

B08 - Parker - Abstract


Simpson, D.S., Pang, J., Weir, A., Kong, I.Y., Fritsch, M., Rashidi, M., Cooney, J.P., Davidson, K.C., Speir, M., Djajawi, T.M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A.S., Conos, S.A., Tye, H., Chow, S.H.,  Rahman, A., Norton, R.S., Naderer, T., Nicholson, S.E., Burgio, G., Man, S.M., Groom, J.R,. Herold, M.J., Hawkins, E.D., Lawlor, K.E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R., Vince, J.E. (2022) Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55, 1–19, March 8, 2022 https://doi.org/10.1016/j.immuni.2022.01.003

B01 - Kashkar - Abstract


Cosentino, K., Hertlein, V., Jenner, A., Dellmann, T., Gojkovic, M., Peña-Blanco, A., Dadsena, S., Wajngarten, N., Danial, J.S.H., Thevathasan, J.V., Mund, M., Ries, J., Garcia-Saez, A.J. (2022) The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular Cell 82, 1-17, February 17, 2022 https://doi.org/10.1016/j.molcel.2022.01.008

A02 - Garcia - Abstract

Past Years publications