Publications

Recent publications 2025

Zecua-Ramirez P, Dunken N, Charura NM, Llamas E, De Quattro C, Mandel A, Langen G, Dagdas Y, Zuccaro A. Autophagy restricts symbiosis-associated cell death and regulates colonization by Serendipita indica in Arabidopsis. Plant Physiol. 2025 Nov 18:kiaf590. doi: 10.1093/plphys/kiaf590. Epub ahead of print. PMID: 41253704.

B03 - Zuccaro - Abstract

Theobald SJ, Dahm K, Lange D, Spintge JB, Winter S, Klingmüller A, Holsten L, Simonis A, De Domenico E, Walczak H, van Uelft M, Schultze JL, Beyer MD, Ulas T, Suárez I, Rybniker J. Deep immune profiling delineates hallmarks of disease heterogeneity in extrapulmonary tuberculosis. Nat Commun. 2025 Nov 10;16(1):9662. doi: 10.1038/s41467-025-65561-x. PMID: 41213960; PMCID: PMC12603278.

A12 - Walczak & B05 - Rybniker - Abstract

Langpape A, Bonasera D, Stroh J, Reese M, Cartolano M, Liccardi G, von Karstedt S. Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL). Cell Death Discov. 2025 Oct 31;11(1):495. doi: 10.1038/s41420-025-02826-w. PMID: 41173858; PMCID: PMC12578790.

A05 - von Karstedt & Assoc. - Liccardi - Abstract

Koerner L, Li X, Silnov E, Laurien L, Pasparakis M. RIPK1 autophosphorylation at S161 mediates cell death and inflammation. J Exp Med. 2025 Dec 1;222(12):e20250279. doi: 10.1084/jem.20250279. Epub 2025 Sep 25. PMID: 40996439; PMCID: PMC12462663.

A01 - Pasparakis - Abstract

Bahat A, Milenkovic D, Cors E, Barnett M, Niftullayev S, Katsalifis A, Schwill M, Kirschner P, MacVicar T, Giavalisco P, Jenninger L, Clausen AR, Paupe V, Prudent J, Larsson NG, Rogg M, Schell C, Muylaert I, Larsson E, Nolte H, Falkenberg M, Langer T. Ribonucleotide incorporation into mitochondrial DNA drives inflammation. Nature. 2025 Sep 24. doi: 10.1038/s41586-025-09541-7. Epub ahead of print. Erratum in: Nature. 2025 Oct;646(8087):E31. doi: 10.1038/s41586-025-09682-9. PMID: 40993386.

A06 - Langer - Abstract

Hildebrandt X, Veli Ö, Hyoubi A, Zinngrebe J, Abdallah AT, Rodefeld J, Hoffmann A, Gardeweg L, Kaya Ö, Wagner E, Lindhorst A, Poggenberg M, Wang Y, Dimmler J, Schillings J, Koci P, Bonechi F, Capuccino LV, Kiefer C, Kelepouras K, Ghosh A, Noé F, Wolfrum C, Singer M, Liccardi G, Luedde T, Yavas A, Ghallab A, Hengstler JG, Antczak P, Gericke M, Winkels H, Blüher M, Walczak H, Annibaldi A, Fischer-Posovszky P, Peltzer N. Linear ubiquitination prevents lipodystrophy and obesity-associated metabolic syndrome. Sci Adv. 2025 Sep 19;11(38):eadw2539. doi: 10.1126/sciadv.adw2539. Epub 2025 Sep 17. PMID: 40961178; PMCID: PMC12442851.

A10 - Pelterz & A12 - Walczak & Assoc. - Annibaldi & Assoc. - Liccardi - Abstract

King LE, Faber L, García-Sáez AJ. Activator of apoptosis harakiri (HRK) localisation at mitochondria alters mitochondrial morphology independently of other BCL-2 proteins. FEBS J. 2025 Sep 12. doi: 10.1111/febs.70255. Epub ahead of print. PMID: 40938785.

A01- Garcia - Abstract

Sakthivelu V, Schmitt A, Odenthal F, Ndoci K, Touet M, Shaib AH, Chihab A, Wani GA, Nieper P, Hartmann GG, Pintelon I, Kisis I, Boecker M, Eckert NM, Iannicelli Caiaffa M, Ibruli O, Weber J, Maresch R, Bebber CM, Chitsaz A, Lütz A, Kim Alves Carpinteiro M, Morris KM, Franchino CA, Benz J, Pérez-Revuelta L, Soriano-Campos JA, Huetzen MA, Goergens J, Jevtic M, Jahn-Kelleter HM, Zempel H, Placzek A, Hennrich AA, Conzelmann KK, Tumbrink HL, Hunold P, Isensee J, Werr L, Gaedke F, Schauss A, Minère M, Müller M, Fenselau H, Liu Y, Heimsoeth A, Gülcüler Balta GS, Walczak H, Frezza C, Jachimowicz RD, George J, Schmiel M, Brägelmann J, Hucho T, von Karstedt S, Peifer M, Annibaldi A, Hänsel-Hertsch R, Persigehl T, Grüll H, Sos ML, Reifenberger G, Fischer M, Adriaensen D, Büttner R, Sage J, Brouns I, Rad R, Thomas RK, Anstötz M, Rizzoli SO, Bergami M, Motori E, Reinhardt HC, Beleggia F. Functional synapses between neurons and small cell lung cancer. Nature. 2025 Sep 10. doi: 10.1038/s41586-025-09434-9. Epub ahead of print. Erratum in: Nature. 2025 Sep 19. doi: 10.1038/s41586-025-09638-z. PMID: 40931078.

A05 - von Karstedt, A12 - Walczak & Assoc. - Annibaldi - Abstract

Lawson AW, Macha A, Neumann U, Gunkel M, Chai J, Behrmann E, Schulze-Lefert P. Purifying recombinant proteins from Nicotiana benthamiana for structural studies. Nat Protoc. 2025 Sep 9. doi: 10.1038/s41596-025-01249-2. Epub ahead of print. PMID: 40926020.

B08 - Schulze-Lefert - Abstract

Ebert LK, Schloesser L, Frech LE, Jain M, Dafinger C, Liebau MC, Benzing T, Schermer B, Slaats GG. The nephronophthisis protein GLIS2/NPHP7 is required for the DNA damage response in kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2025 Sep 1;329(3):F335-F346. doi: 10.1152/ajprenal.00076.2025. Epub 2025 Jul 25. PMID: 40713016.

A09 - Nephrolab - Abstract

Kaya GG, Schwarzer R, Dannappel M, Vlantis K, Göbel U, Kondylis V, Nedospasov SA, Pasparakis M. Unfolded protein response transcription factor XBP1 suppresses necroptosis-induced colitis by reinforcing the mucus barrier. Immunity. 2025 Sep 9;58(9):2208-2225.e6. doi: 10.1016/j.immuni.2025.07.023. Epub 2025 Aug 26. PMID: 40865520.

A01 - Pasparakis - Abstract

Kelepouras K, Saggau J, Bonasera D, Kiefer C, Locci F, Rakhsh-Khorshid H, Grauvogel L, Varanda AB, Peifer M, Loricchio E, Montinaro A, Croon M, Trifunovic A, Prencipe G, Insalaco A, De Benedetti F, Walczak H, Liccardi G. STING induces ZBP1-mediated necroptosis independently of TNFR1 and FADD. Nature. 2025 Aug 20. doi: 10.1038/s41586-025-09536-4. Epub ahead of print. PMID: 40834903.

Assoc. - Liccardi & A12 - Walczak - Abstract

Wang J, Sun X, Xiong F, Lapin D, Lee T, Martin-Ramirez S, Prakken A, Shen Q, Bautor J, Maekawa T, Parker JE. Coordinated actions of NLR-assembled and glutamate receptor-like calcium channels in plant effector-triggered immunity. Proc Natl Acad Sci U S A. 2025 Sep 2;122(35):e2508018122. doi: 10.1073/pnas.2508018122. Epub 2025 Aug 22. PMID: 40844808.

B07 - Maekawa & B08 - Parker - Abstract

Stahl D, Gödel P, Balke-Want H, Gholamipoorfard R, Segbers P, Tetenborg L, Koker M, Dörr J, Gregor L, Bachurski D, Rose F, Simon AG, Good Z, Jakob J, Häupl B, Nill M, Flümann R, Riet T, Lange D, Blakemore SJ, Baurmann H, Voltin CA, Potter N, Schlözer L, Freihammer M, Wagener-Ryczek S, Iuga AI, Heger JM, Ludwig H, Schleifenbaum JK, Propp J, Bröckelmann PJ, Jachimowicz RD, Knittel G, Borchmann S, Merkelbach-Bruse S, Pallasch C, Peifer M, Rybniker J, Quaas A, Nitz M, Brägelmann J, Müller W, Persigehl T, Bozek K, Theobald SJ, Büttner R, Oellerich T, Hallek M, Kobold S, Chmielewski M, Reinhardt HC, Mackall C, Abedpour N, Borchmann P, Ullrich RT. CSF1R⁺ myeloid-monocytic cells drive CAR-T cell resistance in aggressive B cell lymphoma. Cancer Cell. 2025 Aug 11;43(8):1476-1494.e10. doi: 10.1016/j.ccell.2025.05.013. Epub 2025 Jun 12. PMID: 40513575.

B05 - Rybniker - Abstract

Bauernfried S, Komar T, Sterle K, Tanzer MC, Horswill AR, Mann M, Hornung V. Inflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus. J Biol Chem. 2025 Aug 8:110574. doi: 10.1016/j.jbc.2025.110574. Epub ahead of print. PMID: 40784452.

A03 - Hornung - Abstract

Kaul H, Isermann L, Senft K, Popovic M, Georgomanolis T, Baumann L, Sivanesan P, Pouikli A, Nolte H, Lucic B, Hildebrandt X, Seidel K, Gnad T, Gaedke F, Göbel U, Peters F, Cherevatenko M, Park JH, Schauss A, Peltzer N, Brüning JC, Kornfeld JW, Pfeifer A, Langer T, Lusic M, Wickström SA, Frezza C, Trifunovic A. 2-hydroxyglutarate mediates whitening of brown adipocytes coupled to nuclear softening upon mitochondrial dysfunction. Nat Metab. 2025 Aug 1. doi: 10.1038/s42255-025-01332-8. Epub ahead of print. PMID: 40750944.

A06 - Langer & A10 - Peltzer - Abstract

Posor Y, Conduit SE, Pearce W, Morelli D, Constantinou G, Whitehead M, Sebire NJ, Scudamore CL, Peltzer N, Walczak H, Vanhaesebroeck B. Inactivation of PI3K-C2α deregulates cell death pathways and sensitizes to endotoxic shock. Proc Natl Acad Sci U S A. 2025 Jul 22;122(29):e2423358122. doi: 10.1073/pnas.2423358122. Epub 2025 Jul 17. PMID: 40674428; PMCID: PMC12304892.

A10 - Peltzer & A12 - Walczak - Abstract

Braun F, Mandel AM, Blomberg L, Wong MN, Chatzinikolaou G, Meyer DH, Reinelt A, Nair V, Akbar-Haase R, McCown PJ, Haas F, Chen H, Rahmatollahi M, Fermin D, Ebbestad R, Slaats GG, Bork T, Schell C, Koehler S, Brinkkoetter PT, Lindenmeyer MT, Cohen CD, Kann M, Unnersjö-Jess D, Bloch W, Sampson MG, Dollé ME, Puelles VG, Kretzler M, Garinis GA, Huber TB, Schermer B, Benzing T, Schumacher B, Kurschat CE. Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damage. JCI Insight. 2025 May 20;10(12):e172370. doi: 10.1172/jci.insight.172370. PMID: 40392611; PMCID: PMC12220965.

A09 - Nephrolab - Abstract

Stachura P, Lu Z, Kronberg RM, Xu HC, Liu W, Tu JW, Schaal K, Kameri E, Picard D, von Karstedt S, Fischer U, Bhatia S, Lang PA, Borkhardt A, Pandyra AA. Deep transfer learning approach for automated cell death classification reveals novel ferroptosis-inducing agents in subsets of B-ALL. Cell Death Dis. 2025 May 18;16(1):396. doi: 10.1038/s41419-025-07704-y. PMID: 40382332; PMCID: PMC12085637.

A05 - von Karstedt - Abstract

Mantz M, Dewes P, Huesgen PF. Terminomics for plant protease substrate discovery: Achievements, challenges and new opportunities. J Exp Bot. 2025 May 4:eraf173. doi: 10.1093/jxb/eraf173. Epub ahead of print. PMID: 40319448.

CP04 - Huesgen - Abstract

Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S. An atlas of ferroptosis-induced secretomes. Cell Death Differ. 2025 Apr 25. doi: 10.1038/s41418-025-01517-4. Epub ahead of print. PMID: 40281125.

A05 - von Karstedt - Abstract

Oda H, Annibaldi A, Kastner DL, Aksentijevich I. Genetic Regulation of Cell Death: Insights from Autoinflammatory Diseases. Annu Rev Immunol. 2025 Apr;43(1):313-342. doi: 10.1146/annurev-immunol-090222-105848. PMID: 40279314.

A14 - Oda & Assoc. - Annibaldi - Abstract

Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X. doi: 10.1016/j.molcel.2025.03.015. Epub vor dem Druck. PMID: 40209701

A01- Garcia, A02 - Pasparakis, A10 - Peltzer, A12 - Walczak & Assoc. - Liccardi - Abstract

Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422; PMCID: PMC11947162.

A02 - Garcia & A05 - von Karstedt - Abstract

Simonis A., Theobald S. J., Koch A. E., Mummadavarapu R., Mudler J. M., Andromachi P., Göbel U., Acton R., Winter S., Albus A., Holzmann D., Albert M., Hallek M., Walczak H., Ulas T., Koch M., Tessarz P., Hänsel-Hertsch R., Rybniker J., Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages, Mol Syst Biol (2025), DOI:10.1038/s44320-025-00093-6, MSB-2023-11820

B05 - Rybniker - Abstract

Lawson AW, Flores-Ibarra A, Cao Y, An C, Neumann U, Gunkel M, Saur IML, Chai J, Behrmann E, Schulze-Lefert P. The barley MLA13-AVR_A13 heterodimer reveals principles for immunoreceptor recognition of RNase-like powdery mildew effectors. EMBO J. 2025 Feb 13. doi: 10.1038/s44318-025-00373-9. Epub ahead of print. PMID: 39948409.

Assoc. - Schulze-Lefert & B09 - Saur - Abstract

Huang S, Wang J, Song R, Jia A, Xiao Y, Sun Y, Wang L, Mahr D, Wu Z, Han Z, Li X, Parker JE, Chai J. Balanced plant helper NLR activation by a modified host protein complex. Nature. 2025 Feb 12. doi: 10.1038/s41586-024-08521-7. Epub ahead of print. PMID: 39939760.

B08 - Parker - Abstract

Pedrera L, Prieto Clemente L, Dahlhaus A, Lotfipour Nasudivar S, Tishina S, Olmo González D, Stroh J, Yapici FI, Singh RP, Grotehans N, Langer T, García-Sáez AJ, von Karstedt S. Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death Dis. 2025 Jan 25;16(1):40. doi: 10.1038/s41419-024-07312-2. PMID: 39863602; PMCID: PMC11762985.

A02 - Garcia-Saez & A05 - von Karstadt - Abstract

Dunken N, Thomsen T, Zuccaro A. Purine-based infochemicals and immunometabolites: a comparative review of emerging signaling pathways in plants and animals. FEMS Microbiol Rev. 2025 Jan 14;49:fuaf029. doi: 10.1093/femsre/fuaf029. PMID: 40650573; PMCID: PMC12306445.

B03 - Zuccaro - Abstract

Etxebeste-Mitxeltorena M, Flores-Romero H, Ramos-Inza S, Masiá E, Nenchova M, Montesinos J, Martinez-Gonzalez L, Porras G, Orzáez M, Vicent MJ, Gil C, Area-Gomez E, Garcia-Saez AJ, Martinez A. Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model. J Med Chem. 2025 Jan 8. doi: 10.1021/acs.jmedchem.4c01368. Epub ahead of print. PMID: 39778888.

A02 - Garcia-Saez - Abstract

Leng Y, Kümmel F, Zhao M, Molnár I, Doležel J, Logemann E, Köchner P, Xi P, Yang S, Moscou MJ, Fiedler JD, Du Y, Steuernagel B, Meinhardt S, Steffenson BJ, Schulze-Lefert P, Zhong S. A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility. New Phytol. 2025 Feb;245(3):1197-1215. doi: 10.1111/nph.20289. Epub 2024 Dec 6. PMID: 39641654.

Assoc. - Schulze Lefert - Abstract

Past years publications 2nd funding period

2024

Koenig M, Sorger Z, Keh SPY, Doehlemann G, Misas Villamil JC. Quantitative detection of the maize phytocytokine Zip1 utilizing ELISA. J Exp Bot. 2025 Jan 10;76(2):299-311. doi: 10.1093/jxb/erae423. PMID: 39673776; PMCID: PMC11714748.

B02 Döhlemann - Abstract

Wu Y, Xu W, Zhao G, Lei Z, Li K, Liu J, Huang S, Wang J, Zhong X, Yin X, Wang Y, Zhang H, He Y, Ye Z, Meng Y, Chang X, Lin H, Wang X, Gao Y, Chai J, Parker JE, Deng Y, Zhang Y, Gao M, He Z. A canonical protein complex controls immune homeostasis and multipathogen resistance. Science. 2024 Dec 20;386(6728):1405-1412. doi: 10.1126/science.adr2138. Epub 2024 Nov 7. PMID: 39509474.

B08 - Parker - Abstract

Leng Y, Kümmel F, Zhao M, Molnár I, Doležel J, Logemann E, Köchner P, Xi P, Yang S, Moscou MJ, Fiedler JD, Du Y, Steuernagel B, Meinhardt S, Steffenson BJ, Schulze-Lefert P, Zhong S. A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility. New Phytol. 2024 Dec 6. doi: 10.1111/nph.20289. Epub ahead of print. PMID: 39641654.

Assoc. - Schulze Lefert - Abstract

Dunken N, Widmer H, Balcke GU, Straube H, Langen G, Charura NM, Saake P, De Quattro C, Schön J, Rövenich H, Wawra S, Khan M, Djamei A, Zurbriggen MD, Tissier A, Witte CP, Zuccaro A. A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization. Cell Host Microbe. 2024 Nov 19:S1931-3128(24)00406-2. doi: 10.1016/j.chom.2024.10.020. Epub ahead of print. PMID: 39603244.

B03 - Zuccaro - Abstract

Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. PMID: 39542886; PMCID: PMC11564195.

A12 - Walczak - Abstract

Charura N, Llamas E, De Quattro C, Vilchez D, Nowack MK, Zuccaro A. Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana. Elife. 2024 Nov 12;13:RP96266. doi: 10.7554/eLife.96266. PMID: 39531016; PMCID: PMC11556792.

B03 - Zuccaro - Abstract

Karabag D, Heneka MT, Ising C. The putative contribution of cellular senescence to driving tauopathies. Trends Immunol. 2024 Oct;45(10):837-848. doi: 10.1016/j.it.2024.08.006. Epub 2024 Sep 20. PMID: 39306559.

A13 - Ising - Abstract

Joseph AM, Ahmed A, Goc J, Horn V, Fiedler B, Garone D, Grigg JB, Uddin J, Teng F, Fritsch M, Viver E, Sonnenberg GF, RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut. ScienceDirect11 August 202; doi.org/10.1016/j.mucimm.2024.08.0.

B01 - Kashkar und Fritsch - Abstract

Schiffelers LDJ, Tesfamariam YM, Jenster LM, Diehl S, Binder SC, Normann S, Mayr J, Pritzl S, Hagelauer E, Kopp A, Alon A, Geyer M, Ploegh HL, Schmidt FI. Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application. Nat Commun. 2024 Sep 26;15(1):8266. doi: 10.1038/s41467-024-52110-1. PMID: 39327452; PMCID: PMC11427689.

A04 - Schmidt - Abstract

Nagata M, Carvalho Schäfer Y, Wachsmuth L, Pasparakis M. A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses. EMBO J. 2024 Sep 19. doi: 10.1038/s44318-024-00238-7. Epub ahead of print. PMID: 39300211.

A01 - Pasparakis - Abstract

Wang W, Dernst A, Martin B, Lorenzi L, Cadefau-Fabregat M, Phulphagar K, Wagener A, Budden C, Stair N, Wagner T, Färber H, Jaensch A, Stahl R, Duthie F, Schmidt SV, Coll RC, Meissner F, Cuartero S, Latz E, Mangan MSJ. Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation. Cell Rep. 2024 Sep 13;43(9):114736. doi: 10.1016/j.celrep.2024.114736. Epub ahead of print. PMID: 39277863.

A11 - Latz - Abstract

Weiss FD, Alvarez Y, Shakeri F, Sahu A, Leka P, Dernst A, Rollheiser J, Vasconcelos M, Geraci A, Duthie F, Stahl R, Lee HE, Gellner AK, Buness A, Latz E, Meissner F. Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3^tm1Flv mice. Cell Death Differ. 2024 Sep 17. doi: 10.1038/s41418-024-01379-2. Epub ahead of print. PMID: 39289506.

CP04 - Meissner & A11 - Latz - Abstract

Theobald S, Müller T, Lange D, Keck K, Rybniker J. The role of inflammasomes as central inflammatory hubs in Mycobacterium tuberculosis infection. Front. Immunol., 11 September 2024. doi.org/10.3389/fimmu.2024.1436676 (Review)

B05 - Rybniker - Abstract

Hornung V, Gaidt MM. Friendly fire: recognition of self by the innate immune system. Curr Opin Immunol. 2024 Oct;90:102457. doi: 10.1016/j.coi.2024.102457. Epub 2024 Sep 3. PMID: 39232338. (Review)

A03 - Hornung - Abstract

Chen YG, Rieser E, Bhamra A, Surinova S, Kreuzaler P, Ho MH, Tsai WC, Peltzer N, de Miguel D, Walczak H. LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB. Cell Death Differ. 2024 Aug 30. doi: 10.1038/s41418-024-01355-w. Epub ahead of print. PMID: 39215104.

A10 - Peltzer & A12 - Walczak - Abstract

Mooney BC, Doorly CM, Mantz M, García P, Huesgen PF, Graciet E. Hypoxia represses pattern-triggered immune responses in Arabidopsis. Plant Physiol. 2024 Aug 19:kiae432. doi: 10.1093/plphys/kiae432. Epub ahead of print. PMID: 39158089.

CP04 - Huesgen - Abstract

Suárez I, Rauschning D, Schüller C, Hagemeier A, Stecher M, Lehmann C, Schommers P, Schlabe S, Vehreschild JJ, Koll C, Schwarze-Zander C, Wasmuth JC, Klingmüller A, Rockstroh JK, Fätkenheuer G, Boesecke C, Rybniker J. Incidence and risk factors for HIV-tuberculosis coinfection in the Cologne-Bonn region: a retrospective cohort study. Infection. 2024 Aug;52(4):1439-1448. doi: 10.1007/s15010-024-02215-y. Epub 2024 Mar 16. PMID: 38492196; PMCID: PMC11289312.

B05 - Rybniker - Abstract

Szymanska I, Bauernfried S, Komar T, Hornung V. Vaccinia virus F1L blocks the ribotoxic stress response to subvert ZAKα-dependent NLRP1 inflammasome activation. Eur J Immunol. 2024 Jul 31:e2451135. doi: 10.1002/eji.202451135. Epub ahead of print. PMID: 39086059.

A03 - Hornung - Abstract

Wang M, Flaswinkel H, Joshi A, Napoli M, Masgrau-Alsina S, Kamper JM, Henne A, Heinz A, Berouti M, Schmacke NA, Hiller K, Kremmer E, Wefers B, Wurst W, Sperandio M, Ruland J, Fröhlich T, Hornung V. Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation. Nat Commun. 2024 Jul 31;15(1):6438. doi: 10.1038/s41467-024-50104-7. PMID: 39085210; PMCID: PMC11291651.

A03 - Hornung - Abstract

Veli Ö, Kaya Ö, Varanda AB, Hildebrandt X, Xiao P, Estornes Y, Poggenberg M, Wang Y, Pasparakis M, Bertrand MJM, Walczak H, Annibaldi A, Cardozo AK, Peltzer N. RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia. Mol Metab. 2024 Jul 12:101988. doi: 10.1016/j.molmet.2024.101988. Epub ahead of print. PMID: 39004142.

A10 - Peltzer - Abstract

Hasegawa K, Timmers T, Chai J, Maekawa T. A disease resistance assay in Nicotiana benthamiana reveals the immune function of Response to HopBA1. Plant Physiol. 2024 Jul 8:kiae368. doi: 10.1093/plphys/kiae368. Epub ahead of print. PMID: 38976586.

B07 - Maekawa - Abstract

Sun Z, Hornung V. A critical role for palmitoylation in pyroptosis. Mol Cell. 2024 Jun 20;84(12):2218-2220. doi: 10.1016/j.molcel.2024.05.023. PMID: 38906113. (Review)

A03 - Hornung - Abstract

Koerner L, Wachsmuth L, Kumari S, Schwarzer R, Wagner T, Jiao H, Pasparakis M. ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell Death Differ. 2024 Jun 7. doi: 10.1038/s41418-024-01321-6. Epub ahead of print. PMID: 38849574.

A01 - Pasparakis - Abstract

Ma S, An C, Lawson AW, Cao Y, Sun Y, Tan EYJ, Pan J, Jirschitzka J, Kümmel F, Mukhi N, Han Z, Feng S, Wu B, Schulze-Lefert P, Chai J. Oligomerization-mediated autoinhibition and cofactor binding of a plant NLR. Nature. 2024 Jun 12. doi: 10.1038/s41586-024-07668-7. Epub ahead of print. PMID: 38866053.

Assoc. - Schulze Lefert - Abstract

Kelepouras K, Saggau J, Varanda AB, Zrilic M, Kiefer C, Rakhsh-Khorshid H, Lisewski I, Uranga-Murillo I, Arias M, Pardo J, Tonnus W, Linkermann A, Annibaldi A, Walczak H, Liccardi G. The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo. Cell Death Differ. 2024 May 23. doi: 10.1038/s41418-024-01313-6. Epub ahead of print. PMID: 38783091.

A12 - Walczak - Abstract

Imai T, Lin J, Kaya G, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M. 1,2,4. The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity 57, 1–17, https://doi.org/10.1016/j.immuni.2024.04.016

A01 - Pasparakis - Abstract

Oda H, Manthiram K, Chavan PP, Rieser E, Veli Ö, Kaya Ö, Rauch C, Nakabo S, Kuehn HS, Swart M, Wang Y, Çelik NI, Molitor A, Ziaee V, Movahedi N, Shahrooei M, Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nat Immunol. 2024 Apr 12. doi: 10.1038/s41590-024-01817-w. Epub ahead of print. PMID: 38609546.

A14 - Oda, A10 Peltzer & A 12 Walczak - Abstract

Yapici FI, Bebber CM, von Karstedt S. A guide to ferroptosis in cancer. Mol Oncol. 2024 Apr 8. doi: 10.1002/1878-0261.13649. Epub ahead of print. PMID: 38590214. (Review)

A05 - von Karstedt - Abstract

Albert MC, Uranga-Murillo I, Arias M, De Miguel D, Peña N, Montinaro A, Varanda AB, Theobald SJ, Areso I, Saggau J, Koch M, Liccardi G, Peltzer N, Rybniker J, Hurtado-Guerrero R, Merino P, Monzón M, Badiola JJ, Reindl-Schwaighofer R, Sanz-Pamplona R, Cebollada-Solanas A, Megyesfalvi Z, Dome B, Secrier M, Hartmann B, Bergmann M, Pardo J, Walczak H. Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality. Cell Death Differ. 2024 Mar 21. doi: 10.1038/s41418-024-01278-6. Epub ahead of print. PMID: 38514848

A12 - Walczak - Abstract

van Midden KP, Mantz M, Fonovič M, Gazvoda M, Svete J, Huesgen PF, van der Hoorn RAL, Klemenčič M. Mechanistic insights into CrCEP1: A dual-function cysteine protease with endo- and transpeptidase activity. Int J Biol Macromol. 2024 Jun;271(Pt 1):132505. doi: 10.1016/j.ijbiomac.2024.132505. Epub 2024 May 18. PMID: 38768911.

CP04 - Huesgen - Abstract

Shen Q, Hasegawa K, Oelerich N, Prakken A, Tersch LW, Wang J, Reichhardt F, Tersch A, Choo JC, Timmers T, Hofmann K, Parker JE, Chai J, Maekawa T. Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity. Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Epub ahead of print. PMID: 38513655.

B07 - Maekawa & B08 - Parker - Abstract

Song W, Liu L, Yu D, Bernardy H, Jirschitzka J, Huang S, Jia A, Jemielniak W, Acker J, Laessle H, Wang J, Shen Q, Chen W, Li P, Parker JE, Han Z, Schulze-Lefert P, Chai J. Substrate-induced condensation activates plant TIR domain proteins. Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07183-9. Epub ahead of print. PMID: 3848088

B08 - Parker - Abstract

Knopf, J.D., Steigleder, S.S., Korn, F., Kühnle, N., Badenes, M., Tauber, M., Theobald, S.J., Rybniker, J., Adrain, C., and Lemberg, M.K.. (2024) RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling. Nat Commun. 15(1):1528. doi: 10.1038/s41467-024-45615-2.

B05 - Rybniker - Abstract

Past years publications 1st funding period

2023

Gries, R., Chhen, .J, van Gumpel, E., Theobald, S.J., Sonnenkalb, L., Utpatel, C., Metzen, F., Koch, M., Dallenga, T., Djaout, K., Baulard, A., Dal Molin, M., and Rybniker, J. (2023). Discovery of dual-active ethionamide boosters inhibiting the Mycobacteriumtuberculosis ESX-1 secretion system. Cell Chem Biol. S2451-9456(23)00436-1. doi: 10.1016/j.chembiol.2023.12.007. Epub ahead of print. PMID: 38181799.

B05 - Rybniker - Abstract

Moschandrea, C., Kondylis, V., Evangelakos, I., Herholz, M., Schneider, F., Schmidt, C., Yang, M., Ehret, S., Heine, M., Jaeckstein, M.Y., Szczepanowska, K., Schwarzer, R., Baumann, L., Bock, T., Nikitopoulou, E., Brodesser, S., Krüger, M., Frezza, C., Heeren, J., Trifunovic, A., and Pasparakis, M. (2023). Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 20. doi: 10.1038/s41586-023-06857-0.

A01 - Pasparakis - Abstract

Eren, R.O., Kaya, G.G., Schwarzer, R. and Pasparakis, M. (2024). IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 15, 130. doi: 10.1038/s41467-023-44372-y.

A01 - Pasparakis - Abstract

Nickenig, M., Mangan, M.S.J., Lee, H.E., Symeonidis, K., Henne, A., Kaiser, R., Geißmar, E., Garritsen, H., Abdullah, Z., Hiller, K., Latz, E., and Lauterbach, M.A. (2024). Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol. 2024 212, 7-11. doi: 10.4049/jimmunol.2200835.

A04 - Latz - Abstract

Kopp, A., Hagelueken, G., Jamitzky, I., Moecking, J., Schiffelers, L.D.J., Schmidt, F.I., and Geyer, M. (2023) Pyroptosis inhibiting nanobodies block Gasdermin D pore formation. Nat Commun. 14, 7923. doi: 10.1038/s41467-023-43707-z.

A04 - Schmidt - Abstract

Teague, H.C., Lefevre, C., Rieser, E., Wolfram, L., de Miguel, D., Patricio de Oliveira, D., Oliveira, M., Mansur, D.S., Irigoyen, N., Walczak, H. and Ferguson, B.J. (2023) LUBAC is required for RIG-I sensing of RNA viruses. Cell Death Differ. doi: 10.1038/s41418-023-01233-x.

A10 - Walczak - Abstract

Simonis, A., Kreer. C., Albus, A., Rox, K., Yuan, B., Holzmann, D., Wilms, J.A., Zuber, S., Kottege, L., Winter, S., Meyer, M., Schmitt, K., Gruell, H., Theobald, S.J., Hellmann, A.M., Meyer, C., Ercanoglu, M.S., Cramer, N., Munder, A., Hallek, M., Fätkenheuer, G., Koch, M., Seifert, H., Rietschel, E., Marlovits, T.C., van Koningsbruggen-Rietschel, S., Klein, F., and Rybniker, J. (2023). Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa. Cell. 186, 5098-5113.e19. doi: 10.1016/j.cell.2023.10.002.

B05 - Rybniker - Abstract

Sun, Z., Cernilogar, F.M., Horvatic, H., Yeroslaviz, A., Abdullah, Z., Schotta, G. and Hornung. V. (2023) β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4. Cell Rep. 42, 113322. doi: 10.1016/j.celrep.2023.113322. Epub ahead of print. PMID: 37883227.

A03 - Hornung - Abstract

Llamas, E., Koyuncu, S., Lee, H.J., Wehrmann, M., Gutierrez-Garcia, R., Dunken, N., Charura, N., Torres-Montilla, S., Schlimgen, E., Mandel, A.M., Theile, E.B., Grossbach, J., Wagle, P., Lackmann, J.W., Schermer, B., Benzing, T., Beyer, A., Pulido, P., Rodriguez-Concepcion, M., Zuccaro, A. and Vilchez, D. (2023) In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat Aging. doi: 10.1038/s43587-023-00502-1

B03 - Zuccaro - Abstract

Schorn, F., Werthenbach, J.P., Hoffmann, M., Daoud, M., Stachelscheid, J., Schiffmann, L.M., Hildebrandt, X., Lyu, S.I., Peltzer, N., Quaas, A., Vucic, D., Silke, J., Pasparakis, M. and Kashkar, H. (2023) cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. doi: 10.15252/embj.2023113614

B01 - Kashkar & A01 - Pasparakis - Abstract

Czabotar, P.E. and Garcia-Saez, A.J. (2023) Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nat Rev Mol Cell Biol. doi: 10.1038/s41580-023-00629-4 (review)

A02 - García-Sáez - Abstract

Grotehans, N., McGarry, L., Nolte, H., Xavier, V., Kroker, M., Narbona-Pérez, Á.J., Deshwal, S., Giavalisco, P., Langer, T. and MacVicar, T. (2023) Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. EMBO J. doi: 10.15252/embj.2022113256.

A06 - Langer - Abstract

Rieger, J., Fitz, M., Fischer, S.M., Wallmeroth, N., Flores-Romero, H., Fischer, N.M., Brand, L.H., García-Sáez, A.J., Berendzen, K.W. and Mira-Rodado, V. (2023) Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods. Genes (Basel). doi: 10.3390/genes14081638

A02 - García-Sáez - Abstract

Röck, B.F., Shalaby, R. and García-Sáez, A.J. (2023) Pyroptosis Induction and Visualization at the Single-Cell Level Using Optogenetics. Methods Mol Biol. 2696, 135-147. doi: 10.1007/978-1-0716-3350-2_10 (review)

A02 - García-Sáez - Abstract

Cao, Y., Kümmel, F., Logemann, E., Gebauer, J.M., Lawson, A.W., Yu, D., Uthoff, M., Keller, B., Jirschitzka, J., Baumann, U., Tsuda, K., Chai, J. and Schulze-Lefert, P. (2023) Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2307604120

B08 - Schulze-Lefert & Chai - Abstract

Injarabian, L., Willenborg, S., Welcker, D., Sanin, D.E., Pasparakis, M., Kashkar, H. and Eming, S.A. (2023) FADD- and RIPK3-mediated cell death ensures clearance of Ly6C^high wound macrophages from damaged tissue. J Invest Dermatol. doi: 10.1016/j.jid.2023.06.203.

A07 - Eming & B01 - Kashkar & A01 - Pasparakis - Abstract

Martinez Lagunas, K., Savcigil, D.P., Zrilic, M., Carvajal Fraile, C., Craxton, A., Self, E., Uranga-Murillo, I., de Miguel, D., Arias, M., Willenborg, S., Piekarek, M., Albert, MC., Nugraha, K., Lisewski, I., Janakova, E., Igual, N., Tonnus, W., Hildebrandt, X., Ibrahim, M., Ballegeer, M., Saelens, X., Kueh, A., Meier, P., Linkermann, A., Pardo, J., Eming, S., Walczak, H., MacFarlane, M., Peltzer, N., Annibaldi, A. (2023) Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair. Sci Adv. doi: 10.1126/sciadv.adg2829

A07 - Eming & A10 - Peltzer & Walczak & Assoc. Annibaldi - Abstract

Crean, E.E., Bilstein-Schloemer, M., Maekawa, T., Schulze-Lefert, P. and Saur, I.M.L. (2023) A dominant-negative avirulence effector of the barley powdery mildew fungus provides mechanistic insight to barley MLA immune receptor activation. J Exp Bot. doi: 10.1093/jxb/erad285

B08 - Schulze-Lefert & B07 - Maekawa - Abstract

Pedrera, L., Ros, U. and García-Sáez, A.J. (2023) Calcium as a master regulator of ferroptosis and other types of regulated necrosis. Cell Calcuim 114, 102778 . doi: https://doi.org/10.1016/j.ceca.2023.102778

A02 - García-Sáez - Abstract

Barghahn, S., Saridis, G., Mantz, M., Meyer, U., Mellüh, J.C., Misas Villamil, J.C., Huesgen, P.F. and Doehlemann, G. (2023) Combination of transcriptomic, proteomic and degradomic profiling reveals common and distinct patterns of pathogen-induced cell death in maize. Plant J. doi: 10.1111/tpj.16356.

B02 - Döhlemann & Huesgen - Abstract

Koenig, M., Moser, D., Leusner, J., Depotter, J., Doehlemann, G. and Misas Villamil, J.C. (2023) Maize phytocytokines modulate pro-survival host responses and pathogen resistance. Mol Plant Microbe Interact. doi: 10.1094/MPMI-01-23-0005-R.

B02 - Döhlemann - Abstract

Augustin, M., Heyn, F., Ullrich, S., Sandaradura de Silva U, Albert MC, Linne V, Schlotz M, Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fätkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald S.J., and Lehmann C. (2023) Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome. Front Med (Lausanne). 10, 1129288. doi: 10.3389/fmed.2023.1129288

B05 - Rybniker and A10 Walczak - Abstract

Feehan, J.M., Wang, J., Sun, X., Choi, J., Ahn, H.K., Ngou, B.P.M., Parker, J.E., Jones, and J.D.G. (2023). Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation. Proc Natl Acad Sci U S A. 120, e2210406120. doi: 10.1073/pnas.2210406120.

B08 - Parker - Abstract

Hadrian, K., Musial, G., Schönberg, A., Georgiev, T., Küper, C., Bock, F., Jantsch, J., Cursiefen, C., Eming, S.A., and Hos, D. (2023). The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury. Exp Mol Med. 55, 565-573. doi: 10.1038/s12276-023-00954-w.

A07 - Eming - Abstract

Müller, F., Lim, J.K.M., Bebber, C.M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F.I., Nakayama, K., Torres Fernández, L., Brägelmann, J., Leprivier, G., and von Karstedt, S. (2023. Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Cell Death Differ 30, 442-456. doi: 10.1038/s41418-022-01096-8.

A05 - von Karstedt - Abstract

Shalaby, R., Diwan, A., Flores-Romero, H., Hertlein, V., and Garcia Saez, A.J. (2023). Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation. Cell Death Differ 30, 731–741 https://doi.org/10.1038/s41418-022-01078-w

A02 - Garcia Saez - Abstract

Demir, F., Perrar, A., Mantz, M., and Hiesgen, P.F., (2023). Sensitive Plant N-Terminome Profiling with HUNTER. Method Mol Biol. 2447. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2079-3_12

B02 - Huesgen - Abstract

Di Benedetto, C., Khan, T., Serrano-Saenz, S., Rodriguez-Lemus, A., Klomsiri, C., Beutel, T.-M., Thach, A., Walczak, H., and Betancur, P. (2023). Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis. Cancers 15, 967. https://doi.org/10.3390/cancers15030967

A10 - Walczak - Abstract

Deshwal, S., Onishi, M., Tatsuta, T., Bartsch, T., Cors, E., Ried, K., Lemke, L., Nolte, H., Giavalisco, P. and Langer, T. (2023). Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-022-01071-y

A06 - Langer - Abstract

Johanndrees, O., Baggs, E.L., Uhlmann, C., Locci, F., Läßle, H.L., Melkonian, K., Käufer, K., Dongus, J.A., Nakagami, H., Krasileva, K.V., Parker, J.E., and Lapin, D. (2023). Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1 Plant Physiology, Volume 191, Issue 1, January 2023, Pages 626–642, https://doi.org/10.1093/plphys/kiac480

B08 - Parker - Abstract

2022

Pinci, F., Gaidt, M.M., Jung, C., Nagl, D., Kuut, G., Hornung, V. (2022) Tumor necrosis factor is a necroptosis-associated alarmin. Front. Immunol. 13:1074440. doi: 10.3389/fimmu.2022.1074440

A03 - Hornung - Abstract

Kieckhöfer, E., Slaats, G.G., Ebert, L.K., Albert, M.-C., Dafinger, C., Kashkar, H., Benzing, T. & Schermer, B. (2022) Primary cilia suppress Ripk3-mediated necroptosis. Cell Death Discovery 8, Article number: 477 (2022) https://doi.org/10.1038/s41420-022-01272-2

A09 - Schermer & Benzing, B01 - Kashkar - Abstract

Seidel, E., & von Karstedt, S. (2022) Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? Cell Death and Differentiation 8, Article number: 465 (review)

A05 - von Karstedt - Abstract

Schmacke, N.A., O'Duill, F., Gaidt, M.M., Szymanska, I., Kamper, J.M., Schmid-Burgk, J.L., Mädler, S.C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C.A., Harz, H., Fröhlich, A.L.. Pinci, F., Ginhoux, F.L., Beckmann, R., Mann, M., Leonhardt, H., Hornung, V. (2022) IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity 2022 Nov 9;S1074-7613(22)00562-3. doi: 10.1016/j.immuni.2022.10.021.

A03 - Hornung - Abstract

Wang,J., Song, W., Chai, J. (2022) Structure, biochemical function and signaling mechanism of plant NLRs. Molecular Plant https://doi.org/10.1016/j.molp.2022.11.011 (review)

B08 - Chai - Abstract

Ahola, S., Rivera Mejías, P., Hermans, S., Chandragiri, S., Giavalisco, P., Nolte, H., Langer, T. (2022) OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metabolism Vol 34, Issue 11, 1.11.22 pages 17845-1891.e7 https://doi.org/10.1016/j.cmet.2022.08.017

A06 - Langer - Abstract

Kožich, V., Schwahn, B.C., Sokolová, J., Křížková, M., Ditroi, T., Krijtm J., Khalil, Y., Křížek. T., Vaculíková-Fantlová, T., Stibůrková, B., Milla, P., Clayton, P., Barvíková, K., Blessing, H., Sykut-Cegielska, J., Dionisi-Vici, C., Gasperini, A., García-Cazorla, A., Haack, T.B., Honzík, T., Ješina, P., Kuster, A., Laugwitz, L., Martinelli, D., Porta, F., Santer, R., Schwarz, G., Nagy, P. (2022) Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H₂S homeostasis. Redox Biology 58 (2022) 102517 https://doi.org/10.1016/j.redox.2022.102517

A08 - Schwarz - Abstract

Montinaro, A. & Walczak, H. (2022) Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01059-z (review)

A10 - Walczak - Abstract

Jenster, L-M, Lange, K-E, Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers,
L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., Ebner, S., Lapp, D.J., Mayer, J., Moecking, J., Ploegh, H.D. Latz, E., Meissner, F., Geyer, M., Kümmerer, B.M. and Schmidt, F.I., P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J. Exp. Med. 2023 Vol. 220 No. 1 e20220837 https://doi.org/10.1084/jem.20220837

A04 - Latz & Schmidt - Abstract

Maekawa, T., Kashkar, H. & Coll, N.S. Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01060-6 (review)

B01 - Kashkar & B07 - Maekawa - Abstract

Akbal, A., Dernst, A., Lovotti, M., Mangan, M.S.J., McManus, R.M., & Latz, E. How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol (2022). https://doi.org/10.1038/s41423-022-00922-w (review)

A04 - Latz - Abstract

Stafford, C.A., Gassauer, A.-M., de Oliveira Mann, C.C., Tanzer, M.C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S.J., Wiest, A., Pfautsch, M.K., Wurst, W., Yabal, M., Fröhlich, T., Mann, M., Gisch, N., Jae, L.T., & Hornung, V. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation. Nature 609, 590–596 (2022). https://doi.org/10.1038/s41586-022-05125-x

A03 - Hornung - Abstract

Sun, Y., Wang, Y., Zhang, X., Chen, Z., Xia, Y., Wang, L., Sun, Y., Zhang, M., Xiao, Y., Han, Z., Wang, Y., & Chai, J. Plant receptor-like protein activation by a microbial glycoside hydrolase. Nature (2022). https://doi.org/10.1038/s41586-022-05214-x

B08 - Chai - Abstract

Hildebrandt, X., Ibrahim, M. & Peltzer, N. Cell death and inflammation during obesity: “Know my methods, WAT(son)”. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01062-4 (review)

A10 - Peltzer - Abstract

Förderer, A., Li, E., Lawson, A.W., Deng, Y., Sun, Y., Logemann, E., Zhang, X., Wen, J., Han, Z., Chang, J., Chen, Y., Schulze-Lefert, P., & Chai, J. A wheat resistosome defines common principles of immune receptor channels. Nature (2022) https://doi.org/10.1038/s41586-022-05231-w

B08 - Chai & Schulze-Lefert - Abstract

Jiao, H., Wachsmuth, L., Wolf, S., Lohmann, J., Nagata, M., Kaya, G. G., Oikonomou, N., Kondylis, V., Rogg, M., Diebold, M., Tröder, S.E., Zevnik, B., Prinz, M., Schell, C., Young, G.R., Kassiotis, G: & Pasparakis, M. (2022) ADAR1 averts fatal type I interferon induction by ZBP1. Nature (2022). https://doi.org/10.1038/s41586-022-04878-9

A01 - Pasparakis - Abstract

Huang S., Jia, A., Song, W., Hessler, G., Meng, Y., Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Ma, S., Xiao, Y., Yu, D., Hou, J., Liu, R., Sun, H., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science DOI: 10.1126/science.abq3297

B08 - Chai & Parker - Abstract

Jia, A., Huang, S,. Song, W., Wang, J., Meng, Y,. Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Hou, J., Zhang, T., Yu, W., Hessler, G., Li, E., Ma, S., Yu, D., Gebauer, J., Baumann, U., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 10.1126/science.abq8180

B08 - Chai & Parker - Abstract

Theobald, S.J., Simonis, A., Mudler, J.M., Göbel, U., Acton, R., Kohlhas, V., Albert, M.-C., Hellmann, A.-M., Malin, J.J., Winter, S., Hallek, M., Walczak, H., Nguyen, P.-H., Koch, M., Rybniker, J. (2022) Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med e15888 https://doi.org/10.15252/emmm.202215888

B05 - Rybniker & A10 - Walczak - Abstract

Peltzer, N., & Annibaldi, A., (2022) Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. Biomedicines 10(6): 1436 doi: 10.3390/biomedicines10061436 (review)

A10 - Peltzer & Assoc. Annibaldi - Abstract

Xu, L., Wang, J., Xiao, Y., Han, Z., Chai, J. (2022) Structural insight into chitin perceptionby chitin elicitor receptor kinase 1 of Oryza sativa. J Integr Plant Biol. 2022 May 14. doi: 10.1111/jipb.13279.

B07 - Chai - Abstract

Li, X., Huang, C.-H., Sánchez-Rivera, F.J., Kennedy, M.C., Tschaharganeh, D.F., Morris IV, J.P., Montinaro, A., O'Rourke, K.P., Banito, A, Wilkinson, J.E., Chen, C.-C., Ho, Y.-J., Dow, L.E., Tian, S., Luan, W., de Stanchina, E., Zhang, T., Gray, N.S., Walczak, H., Lowe, S.W. (2022) A preclinical platform for assessing antitumor effects andsystemic toxicities of cancer drug targets. PNAS 2022 Vol. 119 No. 17 e2110557119 https://doi.org/10.1073/pnas.2110557119

A10 - Walczak - Abstract

Sanin, D.E., Ge, Y., Marinkovic, E., Kabat, A.M., Castoldi, A., Caputa, G., Grzes, K.M., Curtis, J.D., Thompson, E.A., Willenborg, S., Dichtl, S., Reinhardt, S., Dahl, A., Pearce, E.L., Eming, S.A., Gerbaulet, A., Roers, A., Murray, P.J., Pearce, E.J. (2022) A common framework of monocyte-derived macrophage activation Science Immunology 7, eabl7482 DOI: 10.1126/sciimmunol.abl7482

A07 - Eming - Abstract

Daoud, M., Broxtermann, P.N., Schorn, F., Werthenbach, J.P., Seeger, J.M., Schiffmann, L.M., Brinkmann, K., Vucic, D., Tüting, T., Mauch, C., Kulms, D., Zigrino, P., Kashkar, H. (2022) XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. EMBO Reports (2022)e53608 https://doi.org/10.15252/embr.202153608

B01 - Kashkar - Abstract

Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., Miethe, S., Elling, U., Schermer, B., Baumann, U., Denzel, M.S, (2022) GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. eLife 2022;11:e69223 doi: 10.7554/eLife.69223

A09 - Schermer - Abstract

Peltzer, N. (2022) Linear ubiquitin as a common regulator of cellular stress. FEBS Journal 2022 https://doi.org/10.1111/febs.16425 (review)

A10 - Peltzer - Abstract

Lapin, D., Johanndrees, O., Wu, Z., Parker, J.E. (2022) Molecular innovations in plant TIR-based immunity signaling. The Plant Cell 2022: 00: 1-18 https://doi.org/10.1093/plcell/koac035

B08 - Parker - Abstract

Simpson, D.S., Pang, J., Weir, A., Kong, I.Y., Fritsch, M., Rashidi, M., Cooney, J.P., Davidson, K.C., Speir, M., Djajawi, T.M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A.S., Conos, S.A., Tye, H., Chow, S.H., Rahman, A., Norton, R.S., Naderer, T., Nicholson, S.E., Burgio, G., Man, S.M., Groom, J.R,. Herold, M.J., Hawkins, E.D., Lawlor, K.E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R., Vince, J.E. (2022) Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55, 1–19, March 8, 2022 https://doi.org/10.1016/j.immuni.2022.01.003

B01 - Kashkar - Abstract

Cosentino, K., Hertlein, V., Jenner, A., Dellmann, T., Gojkovic, M., Peña-Blanco, A., Dadsena, S., Wajngarten, N., Danial, J.S.H., Thevathasan, J.V., Mund, M., Ries, J., Garcia-Saez, A.J. (2022) The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular Cell 82, 1-17, February 17, 2022 https://doi.org/10.1016/j.molcel.2022.01.008

A02 - Garcia - Abstract

2021

Parker, J.E., Hessler, G., Cui, H. (2021) A new biochemistry connecting pathogen detection to induced defense in plants. New Phytologist https://doi.org/10.1111/nph.17924

B08 - Parker - Abstract

Christ, A., Latz, E. (2021) Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis. Circulation Research 2021;129:840–842 https://doi.org/10.1161/CIRCRESAHA.121.320131

A04 - Latz - Abstract

Flores-Romero, H., Hohorst, L., John, M., Albert, M.-C., King, L.E., Beckmann, L., Szabo, T., Hertlein, V., Luo, X., Villunger, A., Frenzel, L.P., Kashkar, H., & Garcia-Saez, A.J. (2021) BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO Journal (2021) e108690 DOI10.15252/embj.2021108690

A02 - Garcia-Saez & B01 Kashkar - Abstract

Tanzer, M.C., Bludau, I., Stafford, C.A., Hornung, V., & Mann, M. (2021) Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling. Nature Communications 2021 12:6053, https://doi.org/10.1038/s41467-021-26289-6

A03 - Hornung - Abstract

Kaczmarek, A.T., Bender, D., Gehling, T., Kohl, J.B., Daimagüler, H.S., Santamaria-Araujo, J.A., Liebau, M.C., Koy, A., Cirak, S., Schwarz, G. (2021) A defect in molybdenum cofactor binding causes an attenuated form of sulfite oxidase deficiency. JMD https://doi.org/10.1002/jimd.12454

A08 - Schwarz - Abstract

Willenborg, S., Sanin, D.E., Jais, A., Ding, X.,Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021) Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism 33,1–17 December 7, 2021. https://doi.org/10.1016/j.cmet.2021.10.004

A07 - Eming & A06 - Langer - Abstract

Theobald, S.J., Gräb, J., Fritsch, M., Suárez, I., Eisfeld, H.S., Winter, S., Koch, M., Hölscher, C., Pasparakis, M., Kashkar, H., and Rybniker, J. (2021) Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov. 7, 327 (2021). https://doi.org/10.1038/s41420-021-00716-5

B05 - Rybniker & B01 - Kashkar & A01 - Pasparakis - Abstract

Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J.U.G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., Sauve, F., Coêlho, C.F.F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H.C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V., & Schwaninger, M. (2021) The SARS-CoV-2 main protease M^pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. https://doi.org/10.1038/s41593-021-00926-1

A01 - Pasparakis

Eisfeld, H.S., Simonis, A., Winter, S., Chhen, J., Ströh, L.J., Krey, T., Koch, M., Theobald, S.J., Rybniker, J. (2021). Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages. Viruses 2021, 13, 2076. https://doi.org/10.3390/v13102076

B05 - Rybniker - Abstract

Schünke, H., Göbel, U., Dikic, I., Pasparakis, M. (2021). OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nature Communications 12, Article Number: 5912 https://doi.org/10.1038/s41467-021-25945-1

A01 - Pasparakis - Abstract

Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A-L-, Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke J. & Walczak, H. (2021) Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differentiation. https://doi.org/10.1038/s41418-021-00869-x

A10 - Waczak & A05 - von Karstedt - Abstract

Pruitt, R.N., Locci, F., Wanke, F., Zhang, L., Saile, S.C., Joe, A., Karelina, D., Hua, C., Fröhlich, K., Wan, W.-L., Hu, M., Rao, S., Stolze, S.C., Harzen, A., Gust, A.A., Harter, K., Joosten, M.H.A.J., Thomma, B.P.H.J., Zhou, J.-M., Dangl, J.L., Weigel, D., Nakagami, H., Oecking, C., El Kasmi, F., Parker, J.E., & Nürnberger, T. (2021) The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity. Nature. https://doi.org/10.1038/s41586-021-03829-0

B08 - Parker - Abstract

Bahat, A., MacVicar, T., and Langer, T. (2021) Metabolism and Innate Immunity Meet at the Mitochondria. Frontiers in Cell and Developmental Biology 2021; 9: 720490. doi: 10.3389/fcell.2021.720490

A06 - Langer - Abstract

Jain, R., Zhao, K., Sheridan, J.M. Heinlein, M., Kupresanin, F., Abeysekera, W., Hall, C., Rickard, J., Bouillet, P., Walczak, H., Strasser, A., Silke, J. & Gray, D.H.D. (2021). Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death & Differentiation. https://doi.org/10.1038/s41418-021-00850-8

A10 - Walczak - Abstract

Budden, C.F., Gearing, L.J., Kaiser, R., Standke, L., Hertzog, P J., & Latz, E. (2021). Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses. Journal of Extracellular Vesicles 10, e12127. https://doi.org/10.1002/jev2.1212

A04 - Latz - Abstract

Geueke, A., Mantellato, G., Kueste, F., Schettina, P., Nelles, M., Seeger, J.M., Kashkar, H., & Niemann, C. (2021) The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBO reports e52301 https://doi.org/10.15252/embr.202052301

B01 - Kashkar - Abstract

Llamas, E., Torres-Montilla, S., Lee, H. J., Barja, M. V., Schlimgen, E., Dunken, N., Wagle, P., Werr, W., Zuccaro, A., Rodríguez-Concepción, M., & Vilchez, D (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell, 00, e13446. https://doi.org/10.1111/acel.13446

B03 - Zuccaro - Abstract

Hepowit, N.L., Kolbe, C.-C., Zelle, S.R., Latz, E., MacGurn, J.A. (2021) Regulation of Ubiquitin and Ubiquitin-like Modifiers by Phosphorylation. The FEBS Journal 02 July 2021https://doi.org/10.1111/febs.16101

A04 - Latz

Sun, X., Lapin, D., Feehan, J.M., Stolze, S.C., Kramer, K., Dongus, J.A., Rzemieniewski, J., Blanvillain-Baufumé, S., Harzen, A., Bautor, J., Derbyshire, P., Menke, F.L.H., Finkemeier, I., Nakagami, H., Jones, J.D.G., & Parker, J.E.(2021) Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature Communications 12, Article number: 3335 https://doi.org/10.1038/s41467-021-23614-x

B08 - Parker - Abstract

Alvarez, C.R., Kee, C., Sharma, A.,K., Thomas, L., Schmidt, F.I., Stanifer, M.L., Boulant, S., Herrmann, C. (2021) The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLOS Pathogens June 28, 2021 https://doi.org/10.1371/journal.ppat.1009687

A04 - Schmidt - Abstract

Theobald, S.J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H.S., Albert, M.C., Chhen, J., Motameny, S., Erger, F., Fischer, J., Malin, J.J., Gräb, J., Winter, S., Pouikli, A., David, F., Böll, B., Koehler, P., Vanshylla, K., Gruell, H., Suárez, I., Hallek, M., Fätkenheuer, G., Jung, N., Cornely, O.A., Lehmann, C., Tessarz, P., Altmüller, J., Nürnberg, P., Kashkar, H., Klein, F., Koch, M., and Rybniker, J. (2021) Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med e14150https://doi.org/10.15252/emmm.202114150

B05 - Rybniker & B01 - Kashkar - Abstract

Oikonomou, N., Schuijs, M.J., Chatzigiagkos, A., Androulidaki, A., Aidinis, V., Hammad, H., Lambrecht, B.N., and Pasparakis, M. (2021) Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inﬂammation. Mucosal Immunology https://doi.org/10.1038/s41385-021-00415-5

A01 - Pasparakis - Abstract

Hadrian, K., Willenborg, S., Bock, F., Cursiefen, C., Eming, S.A., and Hos, D. (2021). Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin. Front. Immunol., 07 April 2021 | https://doi.org/10.3389/fimmu.2021.667830

A07 - Eming - Abstract

Sprenger, H.G., MacVicar, T., Bahat, A., Fiedler, K.U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N., Larsson, N.G., Nolte, H., Giavalisco, P. & Langer. T. (2021) Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity. Nature Metabolism 26.04.2021 https://doi.org/10.1038/s42255-021-00385-9

A06 - Langer - Abstract

Kumari, S., Van, T.-M., Preukschat, D., Schuenke, H., Basic, M., Bleich, A., Klein, U., Pasparakis, M. (2021) NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life Science Alliance 15 April 2021. DOI: 10.26508/lsa.202000956

A01 - Pasparakis - Abstract

Bebber, C.M., Thomas, E.S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M.N., Stüker, L., de Pádua Alves,C., Khonsari, A., Dammert, M.A., Parmaksiz, F., Tumbrink, H.L., Beleggia, F., Sos, M.L., Riemer, J., George, J., Brodesser, S., Thomas, R.K., Reinhardt, H.C. & von Karstedt, S. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications volume 12, Article number: 2048. https://doi.org/10.1038/s41467-021-22336-4

A05 - von Karstedt - Abstract

Bauernfried. S., & Hornung, V. (2021) DPP9 restrains NLRP1 activation. Nat Struct Mol Biol. https://doi.org/10.1038/s41594-021-00580-y

A03 - Hornung - Abstract

Xing, Y., Xu, N., Bhandari, D.,D., Lapin, D., Sun, X., Luo, X., Wang, Y., Cao, J., Wang, H., Coaker, G., Parker, J.,E., Liu, J. Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. The Plant Cell Koab075 https://doi.org/10.1093/plcell/koab075

B08 - Parker - Abstract

Mooney, B. C., Mantz, M., Graciet, E, Huesgen, P. F. (2021) Cutting the line: manipulation of plant immunity by bacterial type III effector proteases. J Exp Bot doi:10.1093/jxb/erab095

B02 - Huesgen - Abstract

Zhao, C., Tang, Y., Wang. J., Zeng, Y., Sun, H., Zheng, Z., Su, R., Schneeberger, K., Parker, J.E., Cui, H. (2021) A mis‐regulated cyclic nucleotide‐gated channel mediates cytosolic calcium elevation and activates immunity in Arabidopsis. New Phytologist doi:10.1111/nph.17218

B08 - Parker - Abstract

Bauer, S., Yu, D., Lawson, A.W., Saur, I.M.L., Frantzeskakis, L., Kracher, B., Logemann, E., Chai, J., Maekawa, T., Schulze-Lefert, P. (2021) The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold. PLoS Pathog 17(2): e1009223. doi:10.1371/journal.ppat.1009223

B08 - Schulze-Lefert & Maekawa & Chai - Abstract

Koenig,P.-A., Das, H., Liu, H., Kümmerer, B. M., Gohr, F. N., Jenster, L.-N., Schiffelers, L. D. J., Tesfamariam, Y. M., Uchima, M., Wuerth, J. D., Gatterdam, K., Ruetalo, N., Christensen, M., H., Fandrey, C. I., Normann, S., Tödtmann, J. M. P., Pritzl, S., Hanke, L., Boos, J., Yuan, M., Zhu, X., Schmid-Burgk, J.-L., Kato, H., Schindler, M., Wilson, I. A., Geyer, M., Ludwig, K. U., Hällberg, B. M., Wu, N. C., Schmidt, F. I. (2021) Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science 2021 Jan 12:eabe6230. doi: 10.1126/

A04 - Schmidt - Abstract

Mellis, A-T., Misko, A.L., Arjune, S., Liang, Y., Erdélyi, K., Ditrói, T., Kaczmarek, A.T., Nagy, P., Schwarz, G. (2021) The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism. Redox Biology Volume 38 2021, https://doi.org/10.1016/j.redox.2020.101800

A08 - Schwarz - Abstract

2020

Pinci, F., Gaidt, M. M., Jung,C., Kuut, G., Jackson, M. A., Bauernfried, S., and Hornung, V. (2020) C-tag TNF: a reporter system to study TNF shedding. Journal of Biological Chemistry Vol 295, Issue 52. DOI 10.1074/jbc.RA120.015248

A03 - Hornung - Read more

Pedrera, L., Espiritu, R., A., Ros, U., Weber, J., Schmitt, A., Stroh, J., Hailfinger, S., von Karstedt, S., García-Sáez, A., J. (2020) Ferroptotic pores induce Ca 2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ Dec 17. doi: 10.1038/s41418-020-00691-x

A02 - Garcia-Saez - Read more

Ma, S., Lapin, D., Liu, L., Sun, Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P., Parker, J.E., Chai, J. (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science Vol. 370, Issue 6521, eabe3069; https://doi.org/10.1126/science.abe3069

B08 - Chai, Parker and Schulze Lefert - Read more

Flores‐Romero, H., Ros, U., Garcia-Saez, A.J. (2020) Pore formation in regulated cell death. EMBO J (2020)e105753 https://doi.org/10.15252/embj.2020105753

A02 - Garcia-Saez - Read more

Clemente, L.P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J.,Culmsee, C., von Karstedt, S. (2020) Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells Oct 9;9(10):E2259. doi: 10.3390/cells9102259

A05 - von Karstedt - Read more

Mahdi, L.K., Huang, M., Zhang, X., Nakano, R.T., Kopp, L.B., Saur, I.M.L., Jacob, F., Kovacova, V., Lapin, D., Parker, J.E., Murphy, J.M., Hofmann, K., Schulze-Lefert, P., Chai, J., Maekawa, T. (2020) Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling. Cell Host & Microbe https://doi.org/10.1016/j.chom.2020.08.012

B07 - Maekawa, Chai & B08 - Schulze-Lefert & B06 Hofmann - Read more

Mayer, C.T., Nieke, J.P., Gazumyan, A., Cipolla, M., Wang, Q., Oliveira, Y.T., Ramos, V., Monette, S., Li, Q.Z., Gershwin, M.E., Kashkar, H., Nussenzweig, M.C. (2020) An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells. Proc Natl Acad Sci U S A [Epub ahead of print] https://doi.org/10.1073/pnas.2015372117

B01 - Kashkar - Read more

Albert, M.C., Brinkmann, K., Pokrzywa, W., Günther, S.D., Krönke, M., Hoppe, T. & Kashkar, H. (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis 11, 740. https://doi.org/10.1038/s41419-020-02923-x

B01 - Kashkar - Read more

Schiffmann, L.M., Werthenbach, J.P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S.D., Willenborg,S., Brodesser,S., Lucas, C. Jüngst, C., Albert, M.C., Schorn, F.,Witt, A., Moraes, C.T., Bruns, C.J., Pasparakis, M., Krönke, M., Eming, S.A., Coutelle, O., Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Comm. Volume 11, Article Number: 3653. https://doi.org/10.1038/s41467-020-17472-2

B01 - Kashkar & A07 - Eming & A01 - Pasparakis - Read more

Laurien, L., Nagata, M., Schünke, H., Delanghe, T., Wiederstein, J., L., Kumari, S., Schwarzer, R., Corona, T., Krüger, M., Bertrand, M., J., M., Kondylis, V. & Pasparakis, M.(2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat. Comm. Volume 11, Article number: 1747. https://doi.org/10.1038/s41467-020-15466-8

A01 - Pasparakis - Read more.

Schwarzer, R., Jiao, H., Wachsmuth, L., Tresch, A., Pasparakis, M.(2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity Volume 52, Pages 1-16. https://doi.org/10.1016/j.immuni.2020.04.002 For free acces please go here

A01 - Pasparakis - Read more.

Schwarzer, R., Laurien, L., Pasparakis, M. (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Curr. Opin. Cell Biol. Volume 63, Pages 186-193. https://doi.org/10.1016/j.ceb.2020.02.004

A01 - Pasparakis - Read more.

Jiao, H., Wachsmuth, L., Kumari, S., Schwarzer, R., Lin, J., Eren, R., O., Fisher, A., Lane, R., Young, G., R., Kassiotis, G., Kaiser W., J., Pasparakis, M. (2020). Z-nucleic-acid sensing triggers ZBP1dependent necroptosis and inflammation. Nature, https://doi.org/10.1038/s41586-020-2129-8

A01 - Pasparakis - Read more.

Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H. (2020) Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat. Microbiol. 5:354–367.

B01 - Kashkar & A03 - Hornung - Read more

UNIVERSITÄT ZU KÖLN

Sonderforschungsbereich 1403

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2024

Past years publications 1st funding period

2023

2022

2021

2020