Recent Publications 2025
Yapici FI, Seidel E, Dahlhaus A, Weber J, Schmidt C, de Britto Chaves Filho A, Yang M, Nenchova M, Güngör E, Stroh J, Kotouza I, Beck J, Abdallah AT, Lackmann JW, Bebber CM, Androulidaki A, Kreuzaler P, Schulze A, Frezza C, von Karstedt S. An atlas of ferroptosis-induced secretomes. Cell Death Differ. 2025 Apr 25. doi: 10.1038/s41418-025-01517-4. Epub ahead of print. PMID: 40281125.
A05 - von Karstedt - Abstract
Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X. doi: 10.1016/j.molcel.2025.03.015. Epub vor dem Druck. PMID: 40209701
A01- Garcia, A02 - Pasparakis, A10 - Peltzer, A12 - Walczak & Assoc. - Liccardi - Abstract
Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422; PMCID: PMC11947162.
A02 - Garcia & A05 - von Karstedt - Abstract
Simonis A., Theobald S. J., Koch A. E., Mummadavarapu R., Mudler J. M., Andromachi P., Göbel U., Acton R., Winter S., Albus A., Holzmann D., Albert M., Hallek M., Walczak H., Ulas T., Koch M., Tessarz P., Hänsel-Hertsch R., Rybniker J., Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages, Mol Syst Biol (2025), DOI:10.1038/s44320-025-00093-6, MSB-2023-11820
B05 - Rybniker - Abstract
Huang S, Wang J, Song R, Jia A, Xiao Y, Sun Y, Wang L, Mahr D, Wu Z, Han Z, Li X, Parker JE, Chai J. Balanced plant helper NLR activation by a modified host protein complex. Nature. 2025 Feb 12. doi: 10.1038/s41586-024-08521-7. Epub ahead of print. PMID: 39939760.
B08 - Parker - Abstract
Lawson AW, Flores-Ibarra A, Cao Y, An C, Neumann U, Gunkel M, Saur IML, Chai J, Behrmann E, Schulze-Lefert P. The barley MLA13-AVRA13 heterodimer reveals principles for immunoreceptor recognition of RNase-like powdery mildew effectors. EMBO J. 2025 Feb 13. doi: 10.1038/s44318-025-00373-9. Epub ahead of print. PMID: 39948409.
B08 - Schulze-Lefert & B09 - Saur - Abstract
Pedrera L, Prieto Clemente L, Dahlhaus A, Lotfipour Nasudivar S, Tishina S, Olmo González D, Stroh J, Yapici FI, Singh RP, Grotehans N, Langer T, García-Sáez AJ, von Karstedt S. Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death Dis. 2025 Jan 25;16(1):40. doi: 10.1038/s41419-024-07312-2. PMID: 39863602; PMCID: PMC11762985.
A02 - Garcia-Saez & A05 - von Karstadt - Abstract
Etxebeste-Mitxeltorena M, Flores-Romero H, Ramos-Inza S, Masiá E, Nenchova M, Montesinos J, Martinez-Gonzalez L, Porras G, Orzáez M, Vicent MJ, Gil C, Area-Gomez E, Garcia-Saez AJ, Martinez A. Modulation of Mitochondria-Endoplasmic Reticulum Contacts (MERCs) by Small Molecules as a New Strategy for Restoring Lipid Metabolism in an Amyotrophic Lateral Sclerosis Model. J Med Chem. 2025 Jan 8. doi: 10.1021/acs.jmedchem.4c01368. Epub ahead of print. PMID: 39778888.
A02 - Garcia-Saez - Abstract
Leng Y, Kümmel F, Zhao M, Molnár I, Doležel J, Logemann E, Köchner P, Xi P, Yang S, Moscou MJ, Fiedler JD, Du Y, Steuernagel B, Meinhardt S, Steffenson BJ, Schulze-Lefert P, Zhong S. A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility. New Phytol. 2025 Feb;245(3):1197-1215. doi: 10.1111/nph.20289. Epub 2024 Dec 6. PMID: 39641654.
Assoc. - Schulze Lefert - Abstract
Past Years publications 2nd Funding Period
2024
Wu Y, Xu W, Zhao G, Lei Z, Li K, Liu J, Huang S, Wang J, Zhong X, Yin X, Wang Y, Zhang H, He Y, Ye Z, Meng Y, Chang X, Lin H, Wang X, Gao Y, Chai J, Parker JE, Deng Y, Zhang Y, Gao M, He Z. A canonical protein complex controls immune homeostasis and multipathogen resistance. Science. 2024 Dec 20;386(6728):1405-1412. doi: 10.1126/science.adr2138. Epub 2024 Nov 7. PMID: 39509474.
B08 - Parker - Abstract
Leng Y, Kümmel F, Zhao M, Molnár I, Doležel J, Logemann E, Köchner P, Xi P, Yang S, Moscou MJ, Fiedler JD, Du Y, Steuernagel B, Meinhardt S, Steffenson BJ, Schulze-Lefert P, Zhong S. A barley MLA immune receptor is activated by a fungal nonribosomal peptide effector for disease susceptibility. New Phytol. 2024 Dec 6. doi: 10.1111/nph.20289. Epub ahead of print. PMID: 39641654.
Assoc. - Schulze Lefert - Abstract
Dunken N, Widmer H, Balcke GU, Straube H, Langen G, Charura NM, Saake P, De Quattro C, Schön J, Rövenich H, Wawra S, Khan M, Djamei A, Zurbriggen MD, Tissier A, Witte CP, Zuccaro A. A nucleoside signal generated by a fungal endophyte regulates host cell death and promotes root colonization. Cell Host Microbe. 2024 Nov 19:S1931-3128(24)00406-2. doi: 10.1016/j.chom.2024.10.020. Epub ahead of print. PMID: 39603244.
B03 - Zuccaro - Abstract
Ibruli O, Rose F, Beleggia F, Schmitt A, Cartolano M, Fernandez LT, Saggau J, Bonasera D, Kiljan M, Gozum G, Lichius L, Cai J, Niu LN, Caiaffa MI, Herter JM, Walczak H, Liccardi G, Grüll H, Büttner R, Bosco G, George J, Thomas RK, Bozek K, Reinhardt HC, Herter-Sprie GS. A novel mouse model recapitulating the MMR-defective SCLC subtype uncovers an actionable sensitivity to immune checkpoint blockade. J Cancer Res Clin Oncol. 2024 Nov 14;150(11):496. doi: 10.1007/s00432-024-05942-9. PMID: 39542886; PMCID: PMC11564195.
A12 - Walczak - Abstract
Charura N, Llamas E, De Quattro C, Vilchez D, Nowack MK, Zuccaro A. Root cap cell corpse clearance limits microbial colonization in Arabidopsis thaliana. Elife. 2024 Nov 12;13:RP96266. doi: 10.7554/eLife.96266. PMID: 39531016; PMCID: PMC11556792.
B03 - Zuccaro - Abstract
Joseph AM, Ahmed A, Goc J, Horn V, Fiedler B, Garone D, Grigg JB, Uddin J, Teng F, Fritsch M, Viver E, Sonnenberg GF, RIPK3 and caspase-8 interpret cytokine signals to regulate ILC3 survival in the gut. ScienceDirect11 August 202; doi.org/10.1016/j.mucimm.2024.08.0.
B01 - Kashkar und Fritsch - Abstract
Schiffelers LDJ, Tesfamariam YM, Jenster LM, Diehl S, Binder SC, Normann S, Mayr J, Pritzl S, Hagelauer E, Kopp A, Alon A, Geyer M, Ploegh HL, Schmidt FI. Antagonistic nanobodies implicate mechanism of GSDMD pore formation and potential therapeutic application. Nat Commun. 2024 Sep 26;15(1):8266. doi: 10.1038/s41467-024-52110-1. PMID: 39327452; PMCID: PMC11427689.
A04 - Schmidt - Abstract
Nagata M, Carvalho Schäfer Y, Wachsmuth L, Pasparakis M. A shorter splicing isoform antagonizes ZBP1 to modulate cell death and inflammatory responses. EMBO J. 2024 Sep 19. doi: 10.1038/s44318-024-00238-7. Epub ahead of print. PMID: 39300211.
A01 - Pasparakis - Abstract
Wang W, Dernst A, Martin B, Lorenzi L, Cadefau-Fabregat M, Phulphagar K, Wagener A, Budden C, Stair N, Wagner T, Färber H, Jaensch A, Stahl R, Duthie F, Schmidt SV, Coll RC, Meissner F, Cuartero S, Latz E, Mangan MSJ. Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation. Cell Rep. 2024 Sep 13;43(9):114736. doi: 10.1016/j.celrep.2024.114736. Epub ahead of print. PMID: 39277863.
A11 - Latz - Abstract
Weiss FD, Alvarez Y, Shakeri F, Sahu A, Leka P, Dernst A, Rollheiser J, Vasconcelos M, Geraci A, Duthie F, Stahl R, Lee HE, Gellner AK, Buness A, Latz E, Meissner F. Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice. Cell Death Differ. 2024 Sep 17. doi: 10.1038/s41418-024-01379-2. Epub ahead of print. PMID: 39289506.
CP04 - Meissner & A11 - Latz - Abstract
Theobald S, Müller T, Lange D, Keck K, Rybniker J. The role of inflammasomes as central inflammatory hubs in Mycobacterium tuberculosis infection. Front. Immunol., 11 September 2024. doi.org/10.3389/fimmu.2024.1436676 (Review)
B05 - Rybniker - Abstract
Hornung V, Gaidt MM. Friendly fire: recognition of self by the innate immune system. Curr Opin Immunol. 2024 Oct;90:102457. doi: 10.1016/j.coi.2024.102457. Epub 2024 Sep 3. PMID: 39232338. (Review)
A03 - Hornung - Abstract
Chen YG, Rieser E, Bhamra A, Surinova S, Kreuzaler P, Ho MH, Tsai WC, Peltzer N, de Miguel D, Walczak H. LUBAC enables tumor-promoting LTβ receptor signaling by activating canonical NF-κB. Cell Death Differ. 2024 Aug 30. doi: 10.1038/s41418-024-01355-w. Epub ahead of print. PMID: 39215104.
A10 - Peltzer & A12 - Walczak - Abstract
Mooney BC, Doorly CM, Mantz M, García P, Huesgen PF, Graciet E. Hypoxia represses pattern-triggered immune responses in Arabidopsis. Plant Physiol. 2024 Aug 19:kiae432. doi: 10.1093/plphys/kiae432. Epub ahead of print. PMID: 39158089.
CP04 - Huesgen - Abstract
Suárez I, Rauschning D, Schüller C, Hagemeier A, Stecher M, Lehmann C, Schommers P, Schlabe S, Vehreschild JJ, Koll C, Schwarze-Zander C, Wasmuth JC, Klingmüller A, Rockstroh JK, Fätkenheuer G, Boesecke C, Rybniker J. Incidence and risk factors for HIV-tuberculosis coinfection in the Cologne-Bonn region: a retrospective cohort study. Infection. 2024 Aug;52(4):1439-1448. doi: 10.1007/s15010-024-02215-y. Epub 2024 Mar 16. PMID: 38492196; PMCID: PMC11289312.
B05 - Rybniker - Abstract
Szymanska I, Bauernfried S, Komar T, Hornung V. Vaccinia virus F1L blocks the ribotoxic stress response to subvert ZAKα-dependent NLRP1 inflammasome activation. Eur J Immunol. 2024 Jul 31:e2451135. doi: 10.1002/eji.202451135. Epub ahead of print. PMID: 39086059.
A03 - Hornung - Abstract
Wang M, Flaswinkel H, Joshi A, Napoli M, Masgrau-Alsina S, Kamper JM, Henne A, Heinz A, Berouti M, Schmacke NA, Hiller K, Kremmer E, Wefers B, Wurst W, Sperandio M, Ruland J, Fröhlich T, Hornung V. Phosphorylation of PFKL regulates metabolic reprogramming in macrophages following pattern recognition receptor activation. Nat Commun. 2024 Jul 31;15(1):6438. doi: 10.1038/s41467-024-50104-7. PMID: 39085210; PMCID: PMC11291651.
A03 - Hornung - Abstract
Veli Ö, Kaya Ö, Varanda AB, Hildebrandt X, Xiao P, Estornes Y, Poggenberg M, Wang Y, Pasparakis M, Bertrand MJM, Walczak H, Annibaldi A, Cardozo AK, Peltzer N. RIPK1 is dispensable for cell death regulation in β-cells during hyperglycemia. Mol Metab. 2024 Jul 12:101988. doi: 10.1016/j.molmet.2024.101988. Epub ahead of print. PMID: 39004142.
A10 - Peltzer - Abstract
Hasegawa K, Timmers T, Chai J, Maekawa T. A disease resistance assay in Nicotiana benthamiana reveals the immune function of Response to HopBA1. Plant Physiol. 2024 Jul 8:kiae368. doi: 10.1093/plphys/kiae368. Epub ahead of print. PMID: 38976586.
B07 - Maekawa - Abstract
Sun Z, Hornung V. A critical role for palmitoylation in pyroptosis. Mol Cell. 2024 Jun 20;84(12):2218-2220. doi: 10.1016/j.molcel.2024.05.023. PMID: 38906113. (Review)
A03 - Hornung - Abstract
Koerner L, Wachsmuth L, Kumari S, Schwarzer R, Wagner T, Jiao H, Pasparakis M. ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis. Cell Death Differ. 2024 Jun 7. doi: 10.1038/s41418-024-01321-6. Epub ahead of print. PMID: 38849574.
A01 - Pasparakis - Abstract
Ma S, An C, Lawson AW, Cao Y, Sun Y, Tan EYJ, Pan J, Jirschitzka J, Kümmel F, Mukhi N, Han Z, Feng S, Wu B, Schulze-Lefert P, Chai J. Oligomerization-mediated autoinhibition and cofactor binding of a plant NLR. Nature. 2024 Jun 12. doi: 10.1038/s41586-024-07668-7. Epub ahead of print. PMID: 38866053.
Assoc. - Schulze Lefert - Abstract
Kelepouras K, Saggau J, Varanda AB, Zrilic M, Kiefer C, Rakhsh-Khorshid H, Lisewski I, Uranga-Murillo I, Arias M, Pardo J, Tonnus W, Linkermann A, Annibaldi A, Walczak H, Liccardi G. The importance of murine phospho-MLKL-S345 in situ detection for necroptosis assessment in vivo. Cell Death Differ. 2024 May 23. doi: 10.1038/s41418-024-01313-6. Epub ahead of print. PMID: 38783091.
A12 - Walczak - Abstract
Imai T, Lin J, Kaya G, Ju E, Kondylis V, Kelepouras K, Liccardi G, Kim C, Pasparakis M. 1,2,4. The RIPK1 death domain restrains ZBP1- and TRIF-mediated cell death and inflammation. Immunity 57, 1–17, https://doi.org/10.1016/j.immuni.2024.04.016
A01 - Pasparakis - Abstract
Oda H, Manthiram K, Chavan PP, Rieser E, Veli Ö, Kaya Ö, Rauch C, Nakabo S, Kuehn HS, Swart M, Wang Y, Çelik NI, Molitor A, Ziaee V, Movahedi N, Shahrooei M, Biallelic human SHARPIN loss of function induces autoinflammation and immunodeficiency. Nat Immunol. 2024 Apr 12. doi: 10.1038/s41590-024-01817-w. Epub ahead of print. PMID: 38609546.
A14 - Oda, A10 Peltzer & A 12 Walczak - Abstract
Yapici FI, Bebber CM, von Karstedt S. A guide to ferroptosis in cancer. Mol Oncol. 2024 Apr 8. doi: 10.1002/1878-0261.13649. Epub ahead of print. PMID: 38590214. (Review)
A05 - von Karstedt - Abstract
Albert MC, Uranga-Murillo I, Arias M, De Miguel D, Peña N, Montinaro A, Varanda AB, Theobald SJ, Areso I, Saggau J, Koch M, Liccardi G, Peltzer N, Rybniker J, Hurtado-Guerrero R, Merino P, Monzón M, Badiola JJ, Reindl-Schwaighofer R, Sanz-Pamplona R, Cebollada-Solanas A, Megyesfalvi Z, Dome B, Secrier M, Hartmann B, Bergmann M, Pardo J, Walczak H. Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality. Cell Death Differ. 2024 Mar 21. doi: 10.1038/s41418-024-01278-6. Epub ahead of print. PMID: 38514848
A12 - Walczak - Abstract
van Midden KP, Mantz M, Fonovič M, Gazvoda M, Svete J, Huesgen PF, van der Hoorn RAL, Klemenčič M. Mechanistic insights into CrCEP1: A dual-function cysteine protease with endo- and transpeptidase activity. Int J Biol Macromol. 2024 Jun;271(Pt 1):132505. doi: 10.1016/j.ijbiomac.2024.132505. Epub 2024 May 18. PMID: 38768911.
CP04 - Huesgen - Abstract
Shen Q, Hasegawa K, Oelerich N, Prakken A, Tersch LW, Wang J, Reichhardt F, Tersch A, Choo JC, Timmers T, Hofmann K, Parker JE, Chai J, Maekawa T. Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity. Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Epub ahead of print. PMID: 38513655.
B07 - Maekawa & B08 - Parker - Abstract
Song W, Liu L, Yu D, Bernardy H, Jirschitzka J, Huang S, Jia A, Jemielniak W, Acker J, Laessle H, Wang J, Shen Q, Chen W, Li P, Parker JE, Han Z, Schulze-Lefert P, Chai J. Substrate-induced condensation activates plant TIR domain proteins. Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07183-9. Epub ahead of print. PMID: 3848088
B08 - Parker - Abstract
Knopf, J.D., Steigleder, S.S., Korn, F., Kühnle, N., Badenes, M., Tauber, M., Theobald, S.J., Rybniker, J., Adrain, C., and Lemberg, M.K.. (2024) RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling. Nat Commun. 15(1):1528. doi: 10.1038/s41467-024-45615-2.
B05 - Rybniker - Abstract
Past Years Publications 1st Funding Period
2023
Gries, R., Chhen, .J, van Gumpel, E., Theobald, S.J., Sonnenkalb, L., Utpatel, C., Metzen, F., Koch, M., Dallenga, T., Djaout, K., Baulard, A., Dal Molin, M., and Rybniker, J. (2023). Discovery of dual-active ethionamide boosters inhibiting the Mycobacteriumtuberculosis ESX-1 secretion system. Cell Chem Biol. S2451-9456(23)00436-1. doi: 10.1016/j.chembiol.2023.12.007. Epub ahead of print. PMID: 38181799.
B05 - Rybniker - Abstract
Moschandrea, C., Kondylis, V., Evangelakos, I., Herholz, M., Schneider, F., Schmidt, C., Yang, M., Ehret, S., Heine, M., Jaeckstein, M.Y., Szczepanowska, K., Schwarzer, R., Baumann, L., Bock, T., Nikitopoulou, E., Brodesser, S., Krüger, M., Frezza, C., Heeren, J., Trifunovic, A., and Pasparakis, M. (2023). Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes. Nature. 20. doi: 10.1038/s41586-023-06857-0.
A01 - Pasparakis - Abstract
Eren, R.O., Kaya, G.G., Schwarzer, R. and Pasparakis, M. (2024). IKKε and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 15, 130. doi: 10.1038/s41467-023-44372-y.
A01 - Pasparakis - Abstract
Nickenig, M., Mangan, M.S.J., Lee, H.E., Symeonidis, K., Henne, A., Kaiser, R., Geißmar, E., Garritsen, H., Abdullah, Z., Hiller, K., Latz, E., and Lauterbach, M.A. (2024). Cutting Edge: STING Induces ACLY Activation and Metabolic Adaptations in Human Macrophages through TBK1. J Immunol. 2024 212, 7-11. doi: 10.4049/jimmunol.2200835.
A04 - Latz - Abstract
Kopp, A., Hagelueken, G., Jamitzky, I., Moecking, J., Schiffelers, L.D.J., Schmidt, F.I., and Geyer, M. (2023) Pyroptosis inhibiting nanobodies block Gasdermin D pore formation. Nat Commun. 14, 7923. doi: 10.1038/s41467-023-43707-z.
A04 - Schmidt - Abstract
Teague, H.C., Lefevre, C., Rieser, E., Wolfram, L., de Miguel, D., Patricio de Oliveira, D., Oliveira, M., Mansur, D.S., Irigoyen, N., Walczak, H. and Ferguson, B.J. (2023) LUBAC is required for RIG-I sensing of RNA viruses. Cell Death Differ. doi: 10.1038/s41418-023-01233-x.
A10 - Walczak - Abstract
Simonis, A., Kreer. C., Albus, A., Rox, K., Yuan, B., Holzmann, D., Wilms, J.A., Zuber, S., Kottege, L., Winter, S., Meyer, M., Schmitt, K., Gruell, H., Theobald, S.J., Hellmann, A.M., Meyer, C., Ercanoglu, M.S., Cramer, N., Munder, A., Hallek, M., Fätkenheuer, G., Koch, M., Seifert, H., Rietschel, E., Marlovits, T.C., van Koningsbruggen-Rietschel, S., Klein, F., and Rybniker, J. (2023). Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa. Cell. 186, 5098-5113.e19. doi: 10.1016/j.cell.2023.10.002.
B05 - Rybniker - Abstract
Sun, Z., Cernilogar, F.M., Horvatic, H., Yeroslaviz, A., Abdullah, Z., Schotta, G. and Hornung. V. (2023) β1 integrin signaling governs necroptosis via the chromatin-remodeling factor CHD4. Cell Rep. 42, 113322. doi: 10.1016/j.celrep.2023.113322. Epub ahead of print. PMID: 37883227.
A03 - Hornung - Abstract
Llamas, E., Koyuncu, S., Lee, H.J., Wehrmann, M., Gutierrez-Garcia, R., Dunken, N., Charura, N., Torres-Montilla, S., Schlimgen, E., Mandel, A.M., Theile, E.B., Grossbach, J., Wagle, P., Lackmann, J.W., Schermer, B., Benzing, T., Beyer, A., Pulido, P., Rodriguez-Concepcion, M., Zuccaro, A. and Vilchez, D. (2023) In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat Aging. doi: 10.1038/s43587-023-00502-1
B03 - Zuccaro - Abstract
Schorn, F., Werthenbach, J.P., Hoffmann, M., Daoud, M., Stachelscheid, J., Schiffmann, L.M., Hildebrandt, X., Lyu, S.I., Peltzer, N., Quaas, A., Vucic, D., Silke, J., Pasparakis, M. and Kashkar, H. (2023) cIAPs control RIPK1 kinase activity-dependent and -independent cell death and tissue inflammation. EMBO J. doi: 10.15252/embj.2023113614
B01 - Kashkar & A01 - Pasparakis - Abstract
Czabotar, P.E. and Garcia-Saez, A.J. (2023) Mechanisms of BCL-2 family proteins in mitochondrial apoptosis. Nat Rev Mol Cell Biol. doi: 10.1038/s41580-023-00629-4 (review)
A02 - García-Sáez - Abstract
Grotehans, N., McGarry, L., Nolte, H., Xavier, V., Kroker, M., Narbona-Pérez, Á.J., Deshwal, S., Giavalisco, P., Langer, T. and MacVicar, T. (2023) Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. EMBO J. doi: 10.15252/embj.2022113256.
A06 - Langer - Abstract
Rieger, J., Fitz, M., Fischer, S.M., Wallmeroth, N., Flores-Romero, H., Fischer, N.M., Brand, L.H., García-Sáez, A.J., Berendzen, K.W. and Mira-Rodado, V. (2023) Exploring the Binding Affinity of the ARR2 GARP DNA Binding Domain via Comparative Methods. Genes (Basel). doi: 10.3390/genes14081638
A02 - García-Sáez - Abstract
Röck, B.F., Shalaby, R. and García-Sáez, A.J. (2023) Pyroptosis Induction and Visualization at the Single-Cell Level Using Optogenetics. Methods Mol Biol. 2696, 135-147. doi: 10.1007/978-1-0716-3350-2_10 (review)
A02 - García-Sáez - Abstract
Cao, Y., Kümmel, F., Logemann, E., Gebauer, J.M., Lawson, A.W., Yu, D., Uthoff, M., Keller, B., Jirschitzka, J., Baumann, U., Tsuda, K., Chai, J. and Schulze-Lefert, P. (2023) Structural polymorphisms within a common powdery mildew effector scaffold as a driver of coevolution with cereal immune receptors. Proc Natl Acad Sci U S A. doi: 10.1073/pnas.2307604120
B08 - Schulze-Lefert & Chai - Abstract
Injarabian, L., Willenborg, S., Welcker, D., Sanin, D.E., Pasparakis, M., Kashkar, H. and Eming, S.A. (2023) FADD- and RIPK3-mediated cell death ensures clearance of Ly6Chigh wound macrophages from damaged tissue. J Invest Dermatol. doi: 10.1016/j.jid.2023.06.203.
A07 - Eming & B01 - Kashkar & A01 - Pasparakis - Abstract
Martinez Lagunas, K., Savcigil, D.P., Zrilic, M., Carvajal Fraile, C., Craxton, A., Self, E., Uranga-Murillo, I., de Miguel, D., Arias, M., Willenborg, S., Piekarek, M., Albert, MC., Nugraha, K., Lisewski, I., Janakova, E., Igual, N., Tonnus, W., Hildebrandt, X., Ibrahim, M., Ballegeer, M., Saelens, X., Kueh, A., Meier, P., Linkermann, A., Pardo, J., Eming, S., Walczak, H., MacFarlane, M., Peltzer, N., Annibaldi, A. (2023) Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair. Sci Adv. doi: 10.1126/sciadv.adg2829
A07 - Eming & A10 - Peltzer & Walczak & Assoc. Annibaldi - Abstract
Crean, E.E., Bilstein-Schloemer, M., Maekawa, T., Schulze-Lefert, P. and Saur, I.M.L. (2023) A dominant-negative avirulence effector of the barley powdery mildew fungus provides mechanistic insight to barley MLA immune receptor activation. J Exp Bot. doi: 10.1093/jxb/erad285
B08 - Schulze-Lefert & B07 - Maekawa - Abstract
Pedrera, L., Ros, U. and García-Sáez, A.J. (2023) Calcium as a master regulator of ferroptosis and other types of regulated necrosis. Cell Calcuim 114, 102778 . doi: https://doi.org/10.1016/j.ceca.2023.102778
A02 - García-Sáez - Abstract
Barghahn, S., Saridis, G., Mantz, M., Meyer, U., Mellüh, J.C., Misas Villamil, J.C., Huesgen, P.F. and Doehlemann, G. (2023) Combination of transcriptomic, proteomic and degradomic profiling reveals common and distinct patterns of pathogen-induced cell death in maize. Plant J. doi: 10.1111/tpj.16356.
B02 - Döhlemann & Huesgen - Abstract
Koenig, M., Moser, D., Leusner, J., Depotter, J., Doehlemann, G. and Misas Villamil, J.C. (2023) Maize phytocytokines modulate pro-survival host responses and pathogen resistance. Mol Plant Microbe Interact. doi: 10.1094/MPMI-01-23-0005-R.
B02 - Döhlemann - Abstract
Augustin, M., Heyn, F., Ullrich, S., Sandaradura de Silva U, Albert MC, Linne V, Schlotz M, Schommers P, Pracht E, Horn C, Suarez I, Simonis A, Picard LK, Zoufaly A, Wenisch C, Fätkenheuer G, Gruell H, Klein F, Hallek M, Walczak H, Rybniker J, Theobald S.J., and Lehmann C. (2023) Immunological fingerprint in coronavirus disease-19 convalescents with and without post-COVID syndrome. Front Med (Lausanne). 10, 1129288. doi: 10.3389/fmed.2023.1129288
B05 - Rybniker and A10 Walczak - Abstract
Feehan, J.M., Wang, J., Sun, X., Choi, J., Ahn, H.K., Ngou, B.P.M., Parker, J.E., Jones, and J.D.G. (2023). Oligomerization of a plant helper NLR requires cell-surface and intracellular immune receptor activation. Proc Natl Acad Sci U S A. 120, e2210406120. doi: 10.1073/pnas.2210406120.
B08 - Parker - Abstract
Hadrian, K., Musial, G., Schönberg, A., Georgiev, T., Küper, C., Bock, F., Jantsch, J., Cursiefen, C., Eming, S.A., and Hos, D. (2023). The role of the osmosensitive transcription factor NFAT5 in corneal edema resorption after injury. Exp Mol Med. 55, 565-573. doi: 10.1038/s12276-023-00954-w.
A07 - Eming - Abstract
Müller, F., Lim, J.K.M., Bebber, C.M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F.I., Nakayama, K., Torres Fernández, L., Brägelmann, J., Leprivier, G., and von Karstedt, S. (2023. Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Cell Death Differ 30, 442-456. doi: 10.1038/s41418-022-01096-8.
A05 - von Karstedt - Abstract
Shalaby, R., Diwan, A., Flores-Romero, H., Hertlein, V., and Garcia Saez, A.J. (2023). Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation. Cell Death Differ 30, 731–741 https://doi.org/10.1038/s41418-022-01078-w
A02 - Garcia Saez - Abstract
Demir, F., Perrar, A., Mantz, M., and Hiesgen, P.F., (2023). Sensitive Plant N-Terminome Profiling with HUNTER. Method Mol Biol. 2447. Humana, New York, NY. https://doi.org/10.1007/978-1-0716-2079-3_12
B02 - Huesgen - Abstract
Di Benedetto, C., Khan, T., Serrano-Saenz, S., Rodriguez-Lemus, A., Klomsiri, C., Beutel, T.-M., Thach, A., Walczak, H., and Betancur, P. (2023). Enhancer Clusters Drive Type I Interferon-Induced TRAIL Overexpression in Cancer, and Its Intracellular Protein Accumulation Fails to Induce Apoptosis. Cancers 15, 967. https://doi.org/10.3390/cancers15030967
A10 - Walczak - Abstract
Deshwal, S., Onishi, M., Tatsuta, T., Bartsch, T., Cors, E., Ried, K., Lemke, L., Nolte, H., Giavalisco, P. and Langer, T. (2023). Mitochondria regulate intracellular coenzyme Q transport and ferroptotic resistance via STARD7. Nat Cell Biol (2023). https://doi.org/10.1038/s41556-022-01071-y
A06 - Langer - Abstract
Johanndrees, O., Baggs, E.L., Uhlmann, C., Locci, F., Läßle, H.L., Melkonian, K., Käufer, K., Dongus, J.A., Nakagami, H., Krasileva, K.V., Parker, J.E., and Lapin, D. (2023). Variation in plant Toll/Interleukin-1 receptor domain protein dependence on ENHANCED DISEASE SUSCEPTIBILITY 1 Plant Physiology, Volume 191, Issue 1, January 2023, Pages 626–642, https://doi.org/10.1093/plphys/kiac480
B08 - Parker - Abstract
2022
Pinci, F., Gaidt, M.M., Jung, C., Nagl, D., Kuut, G., Hornung, V. (2022) Tumor necrosis factor is a necroptosis-associated alarmin. Front. Immunol. 13:1074440. doi: 10.3389/fimmu.2022.1074440
A03 - Hornung - Abstract
Kieckhöfer, E., Slaats, G.G., Ebert, L.K., Albert, M.-C., Dafinger, C., Kashkar, H., Benzing, T. & Schermer, B. (2022) Primary cilia suppress Ripk3-mediated necroptosis. Cell Death Discovery 8, Article number: 477 (2022) https://doi.org/10.1038/s41420-022-01272-2
A09 - Schermer & Benzing, B01 - Kashkar - Abstract
Seidel, E., & von Karstedt, S. (2022) Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? Cell Death and Differentiation 8, Article number: 465 (review)
A05 - von Karstedt - Abstract
Schmacke, N.A., O'Duill, F., Gaidt, M.M., Szymanska, I., Kamper, J.M., Schmid-Burgk, J.L., Mädler, S.C., Mackens-Kiani, T., Kozaki, T., Chauhan, D., Nagl, D., Stafford, C.A., Harz, H., Fröhlich, A.L.. Pinci, F., Ginhoux, F.L., Beckmann, R., Mann, M., Leonhardt, H., Hornung, V. (2022) IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network. Immunity 2022 Nov 9;S1074-7613(22)00562-3. doi: 10.1016/j.immuni.2022.10.021.
A03 - Hornung - Abstract
Wang,J., Song, W., Chai, J. (2022) Structure, biochemical function and signaling mechanism of plant NLRs. Molecular Plant https://doi.org/10.1016/j.molp.2022.11.011 (review)
B08 - Chai - Abstract
Ahola, S., Rivera Mejías, P., Hermans, S., Chandragiri, S., Giavalisco, P., Nolte, H., Langer, T. (2022) OMA1-mediated integrated stress response protects against ferroptosis in mitochondrial cardiomyopathy. Cell Metabolism Vol 34, Issue 11, 1.11.22 pages 17845-1891.e7 https://doi.org/10.1016/j.cmet.2022.08.017
A06 - Langer - Abstract
Kožich, V., Schwahn, B.C., Sokolová, J., Křížková, M., Ditroi, T., Krijtm J., Khalil, Y., Křížek. T., Vaculíková-Fantlová, T., Stibůrková, B., Milla, P., Clayton, P., Barvíková, K., Blessing, H., Sykut-Cegielska, J., Dionisi-Vici, C., Gasperini, A., García-Cazorla, A., Haack, T.B., Honzík, T., Ješina, P., Kuster, A., Laugwitz, L., Martinelli, D., Porta, F., Santer, R., Schwarz, G., Nagy, P. (2022) Human ultrarare genetic disorders of sulfur metabolism demonstrate redundancies in H2S homeostasis. Redox Biology 58 (2022) 102517 https://doi.org/10.1016/j.redox.2022.102517
A08 - Schwarz - Abstract
Montinaro, A. & Walczak, H. (2022) Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01059-z (review)
A10 - Walczak - Abstract
Jenster, L-M, Lange, K-E, Normann, S., vom Hemdt, A., Wuerth, J.D., Schiffelers,
L.D.J., Tesfamariam, Y.M., Gohr, F.N., Klein, L., Kaltheuner, I.H., Ebner, S., Lapp, D.J., Mayer, J., Moecking, J., Ploegh, H.D. Latz, E., Meissner, F., Geyer, M., Kümmerer, B.M. and Schmidt, F.I., P38 kinases mediate NLRP1 inflammasome activation after ribotoxic stress response and virus infection. J. Exp. Med. 2023 Vol. 220 No. 1 e20220837 https://doi.org/10.1084/jem.20220837
A04 - Latz & Schmidt - Abstract
Maekawa, T., Kashkar, H. & Coll, N.S. Dying in self-defence: a comparative overview of immunogenic cell death signalling in animals and plants. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01060-6 (review)
B01 - Kashkar & B07 - Maekawa - Abstract
Akbal, A., Dernst, A., Lovotti, M., Mangan, M.S.J., McManus, R.M., & Latz, E. How location and cellular signaling combine to activate the NLRP3 inflammasome. Cell Mol Immunol (2022). https://doi.org/10.1038/s41423-022-00922-w (review)
A04 - Latz - Abstract
Stafford, C.A., Gassauer, A.-M., de Oliveira Mann, C.C., Tanzer, M.C., Fessler, E., Wefers, B., Nagl, D., Kuut, G., Sulek, K., Vasilopoulou, C., Schwojer, S.J., Wiest, A., Pfautsch, M.K., Wurst, W., Yabal, M., Fröhlich, T., Mann, M., Gisch, N., Jae, L.T., & Hornung, V. Phosphorylation of muramyl peptides by NAGK is required for NOD2 activation. Nature 609, 590–596 (2022). https://doi.org/10.1038/s41586-022-05125-x
A03 - Hornung - Abstract
Sun, Y., Wang, Y., Zhang, X., Chen, Z., Xia, Y., Wang, L., Sun, Y., Zhang, M., Xiao, Y., Han, Z., Wang, Y., & Chai, J. Plant receptor-like protein activation by a microbial glycoside hydrolase. Nature (2022). https://doi.org/10.1038/s41586-022-05214-x
B08 - Chai - Abstract
Hildebrandt, X., Ibrahim, M. & Peltzer, N. Cell death and inflammation during obesity: “Know my methods, WAT(son)”. Cell Death Differ (2022). https://doi.org/10.1038/s41418-022-01062-4 (review)
A10 - Peltzer - Abstract
Förderer, A., Li, E., Lawson, A.W., Deng, Y., Sun, Y., Logemann, E., Zhang, X., Wen, J., Han, Z., Chang, J., Chen, Y., Schulze-Lefert, P., & Chai, J. A wheat resistosome defines common principles of immune receptor channels. Nature (2022) https://doi.org/10.1038/s41586-022-05231-w
B08 - Chai & Schulze-Lefert - Abstract
Jiao, H., Wachsmuth, L., Wolf, S., Lohmann, J., Nagata, M., Kaya, G. G., Oikonomou, N., Kondylis, V., Rogg, M., Diebold, M., Tröder, S.E., Zevnik, B., Prinz, M., Schell, C., Young, G.R., Kassiotis, G: & Pasparakis, M. (2022) ADAR1 averts fatal type I interferon induction by ZBP1. Nature (2022). https://doi.org/10.1038/s41586-022-04878-9
A01 - Pasparakis - Abstract
Huang S., Jia, A., Song, W., Hessler, G., Meng, Y., Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Ma, S., Xiao, Y., Yu, D., Hou, J., Liu, R., Sun, H., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity. Science DOI: 10.1126/science.abq3297
B08 - Chai & Parker - Abstract
Jia, A., Huang, S,. Song, W., Wang, J., Meng, Y,. Sun, Y., Xu, L., Laessle, H., Jirschitzka, J., Hou, J., Zhang, T., Yu, W., Hessler, G., Li, E., Ma, S., Yu, D., Gebauer, J., Baumann, U., Liu, X., Han, Z., Chang, J., Parker, J.E., Chai, J. (2022) TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity. Science 10.1126/science.abq8180
B08 - Chai & Parker - Abstract
Theobald, S.J., Simonis, A., Mudler, J.M., Göbel, U., Acton, R., Kohlhas, V., Albert, M.-C., Hellmann, A.-M., Malin, J.J., Winter, S., Hallek, M., Walczak, H., Nguyen, P.-H., Koch, M., Rybniker, J. (2022) Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med e15888 https://doi.org/10.15252/emmm.202215888
B05 - Rybniker & A10 - Walczak - Abstract
Peltzer, N., & Annibaldi, A., (2022) Cell Death-Related Ubiquitin Modifications in Inflammatory Syndromes: From Mice to Men. Biomedicines 10(6): 1436 doi: 10.3390/biomedicines10061436 (review)
A10 - Peltzer & Assoc. Annibaldi - Abstract
Xu, L., Wang, J., Xiao, Y., Han, Z., Chai, J. (2022) Structural insight into chitin perceptionby chitin elicitor receptor kinase 1 of Oryza sativa. J Integr Plant Biol. 2022 May 14. doi: 10.1111/jipb.13279.
B07 - Chai - Abstract
Li, X., Huang, C.-H., Sánchez-Rivera, F.J., Kennedy, M.C., Tschaharganeh, D.F., Morris IV, J.P., Montinaro, A., O'Rourke, K.P., Banito, A, Wilkinson, J.E., Chen, C.-C., Ho, Y.-J., Dow, L.E., Tian, S., Luan, W., de Stanchina, E., Zhang, T., Gray, N.S., Walczak, H., Lowe, S.W. (2022) A preclinical platform for assessing antitumor effects andsystemic toxicities of cancer drug targets. PNAS 2022 Vol. 119 No. 17 e2110557119 https://doi.org/10.1073/pnas.2110557119
A10 - Walczak - Abstract
Sanin, D.E., Ge, Y., Marinkovic, E., Kabat, A.M., Castoldi, A., Caputa, G., Grzes, K.M., Curtis, J.D., Thompson, E.A., Willenborg, S., Dichtl, S., Reinhardt, S., Dahl, A., Pearce, E.L., Eming, S.A., Gerbaulet, A., Roers, A., Murray, P.J., Pearce, E.J. (2022) A common framework of monocyte-derived macrophage activation Science Immunology 7, eabl7482 DOI: 10.1126/sciimmunol.abl7482
A07 - Eming - Abstract
Daoud, M., Broxtermann, P.N., Schorn, F., Werthenbach, J.P., Seeger, J.M., Schiffmann, L.M., Brinkmann, K., Vucic, D., Tüting, T., Mauch, C., Kulms, D., Zigrino, P., Kashkar, H. (2022) XIAP promotes melanoma growth by inducing tumour neutrophil infiltration. EMBO Reports (2022)e53608 https://doi.org/10.15252/embr.202153608
B01 - Kashkar - Abstract
Kroef, V., Ruegenberg, S., Horn, M., Allmeroth, K., Ebert, L., Bozkus, S., Miethe, S., Elling, U., Schermer, B., Baumann, U., Denzel, M.S, (2022) GFPT2/GFAT2 and AMDHD2 act in tandem to control the hexosamine pathway. eLife 2022;11:e69223 doi: 10.7554/eLife.69223
A09 - Schermer - Abstract
Peltzer, N. (2022) Linear ubiquitin as a common regulator of cellular stress. FEBS Journal 2022 https://doi.org/10.1111/febs.16425 (review)
A10 - Peltzer - Abstract
Lapin, D., Johanndrees, O., Wu, Z., Parker, J.E. (2022) Molecular innovations in plant TIR-based immunity signaling. The Plant Cell 2022: 00: 1-18 https://doi.org/10.1093/plcell/koac035
B08 - Parker - Abstract
Simpson, D.S., Pang, J., Weir, A., Kong, I.Y., Fritsch, M., Rashidi, M., Cooney, J.P., Davidson, K.C., Speir, M., Djajawi, T.M., Hughes, S., Mackiewicz, L., Dayton, M., Anderton, H., Doerflinger, M., Deng, Y., Huang, A.S., Conos, S.A., Tye, H., Chow, S.H., Rahman, A., Norton, R.S., Naderer, T., Nicholson, S.E., Burgio, G., Man, S.M., Groom, J.R,. Herold, M.J., Hawkins, E.D., Lawlor, K.E., Strasser, A., Silke, J., Pellegrini, M., Kashkar, H., Feltham, R., Vince, J.E. (2022) Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway. Immunity 55, 1–19, March 8, 2022 https://doi.org/10.1016/j.immuni.2022.01.003
B01 - Kashkar - Abstract
Cosentino, K., Hertlein, V., Jenner, A., Dellmann, T., Gojkovic, M., Peña-Blanco, A., Dadsena, S., Wajngarten, N., Danial, J.S.H., Thevathasan, J.V., Mund, M., Ries, J., Garcia-Saez, A.J. (2022) The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation. Molecular Cell 82, 1-17, February 17, 2022 https://doi.org/10.1016/j.molcel.2022.01.008
A02 - Garcia - Abstract
2021
Parker, J.E., Hessler, G., Cui, H. (2021) A new biochemistry connecting pathogen detection to induced defense in plants. New Phytologist https://doi.org/10.1111/nph.17924
B08 - Parker - Abstract
Christ, A., Latz, E. (2021) Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis. Circulation Research 2021;129:840–842 https://doi.org/10.1161/CIRCRESAHA.121.320131
A04 - Latz - Abstract
Flores-Romero, H., Hohorst, L., John, M., Albert, M.-C., King, L.E., Beckmann, L., Szabo, T., Hertlein, V., Luo, X., Villunger, A., Frenzel, L.P., Kashkar, H., & Garcia-Saez, A.J. (2021) BCL-2-family protein tBID can act as a BAX-like effector of apoptosis. The EMBO Journal (2021) e108690 DOI10.15252/embj.2021108690
A02 - Garcia-Saez & B01 Kashkar - Abstract
Tanzer, M.C., Bludau, I., Stafford, C.A., Hornung, V., & Mann, M. (2021) Phosphoproteome profiling uncovers a key role for CDKs in TNF signaling. Nature Communications 2021 12:6053, https://doi.org/10.1038/s41467-021-26289-6
A03 - Hornung - Abstract
Kaczmarek, A.T., Bender, D., Gehling, T., Kohl, J.B., Daimagüler, H.S., Santamaria-Araujo, J.A., Liebau, M.C., Koy, A., Cirak, S., Schwarz, G. (2021) A defect in molybdenum cofactor binding causes an attenuated form of sulfite oxidase deficiency. JMD https://doi.org/10.1002/jimd.12454
A08 - Schwarz - Abstract
Willenborg, S., Sanin, D.E., Jais, A., Ding, X.,Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J.L., Gerbaulet, A., Roers, A., Pearce, E.J., Brüning, J.C., Trifunovic, A., Eming, S.A. (2021) Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing. Cell Metabolism 33,1–17 December 7, 2021. https://doi.org/10.1016/j.cmet.2021.10.004
A07 - Eming & A06 - Langer - Abstract
Theobald, S.J., Gräb, J., Fritsch, M., Suárez, I., Eisfeld, H.S., Winter, S., Koch, M., Hölscher, C., Pasparakis, M., Kashkar, H., and Rybniker, J. (2021) Gasdermin D mediates host cell death but not interleukin-1β secretion in Mycobacterium tuberculosis-infected macrophages. Cell Death Discov. 7, 327 (2021). https://doi.org/10.1038/s41420-021-00716-5
B05 - Rybniker & B01 - Kashkar & A01 - Pasparakis - Abstract
Wenzel, J., Lampe, J., Müller-Fielitz, H., Schuster, R., Zille, M., Müller, K., Krohn, M., Körbelin, J., Zhang, L., Özorhan, Ü., Neve, V., Wagner, J.U.G., Bojkova, D., Shumliakivska, M., Jiang, Y., Fähnrich, A., Ott, F., Sencio, V., Robil, C., Pfefferle, S., Sauve, F., Coêlho, C.F.F., Franz, J., Spiecker, F., Lembrich, B., Binder, S., Feller, N., König, P., Busch, H., Collin, L., Villaseñor, R., Jöhren, O., Altmeppen, H.C., Pasparakis, M., Dimmeler, S., Cinatl, J., Püschel, K., Zelic, M., Ofengeim, D., Stadelmann, C., Trottein, F., Nogueiras, R., Hilgenfeld, R., Glatzel, M., Prevot, V., & Schwaninger, M. (2021) The SARS-CoV-2 main protease Mpro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells. Nat Neurosci. https://doi.org/10.1038/s41593-021-00926-1
A01 - Pasparakis
Eisfeld, H.S., Simonis, A., Winter, S., Chhen, J., Ströh, L.J., Krey, T., Koch, M., Theobald, S.J., Rybniker, J. (2021). Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages. Viruses 2021, 13, 2076. https://doi.org/10.3390/v13102076
B05 - Rybniker - Abstract
Schünke, H., Göbel, U., Dikic, I., Pasparakis, M. (2021). OTULIN inhibits RIPK1-mediated keratinocyte necroptosis to prevent skin inflammation in mice. Nature Communications 12, Article Number: 5912 https://doi.org/10.1038/s41467-021-25945-1
A01 - Pasparakis - Abstract
Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A-L-, Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke J. & Walczak, H. (2021) Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differentiation. https://doi.org/10.1038/s41418-021-00869-x
A10 - Waczak & A05 - von Karstedt - Abstract
Pruitt, R.N., Locci, F., Wanke, F., Zhang, L., Saile, S.C., Joe, A., Karelina, D., Hua, C., Fröhlich, K., Wan, W.-L., Hu, M., Rao, S., Stolze, S.C., Harzen, A., Gust, A.A., Harter, K., Joosten, M.H.A.J., Thomma, B.P.H.J., Zhou, J.-M., Dangl, J.L., Weigel, D., Nakagami, H., Oecking, C., El Kasmi, F., Parker, J.E., & Nürnberger, T. (2021) The EDS1–PAD4–ADR1 node mediates Arabidopsis pattern-triggered immunity. Nature. https://doi.org/10.1038/s41586-021-03829-0
B08 - Parker - Abstract
Bahat, A., MacVicar, T., and Langer, T. (2021) Metabolism and Innate Immunity Meet at the Mitochondria. Frontiers in Cell and Developmental Biology 2021; 9: 720490. doi: 10.3389/fcell.2021.720490
A06 - Langer - Abstract
Jain, R., Zhao, K., Sheridan, J.M. Heinlein, M., Kupresanin, F., Abeysekera, W., Hall, C., Rickard, J., Bouillet, P., Walczak, H., Strasser, A., Silke, J. & Gray, D.H.D. (2021). Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death & Differentiation. https://doi.org/10.1038/s41418-021-00850-8
A10 - Walczak - Abstract
Budden, C.F., Gearing, L.J., Kaiser, R., Standke, L., Hertzog, P J., & Latz, E. (2021). Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses. Journal of Extracellular Vesicles 10, e12127. https://doi.org/10.1002/jev2.1212
A04 - Latz - Abstract
Geueke, A., Mantellato, G., Kueste, F., Schettina, P., Nelles, M., Seeger, J.M., Kashkar, H., & Niemann, C. (2021) The anti-apoptotic Bcl-2 protein regulates hair follicle stem cell function. EMBO reports e52301 https://doi.org/10.15252/embr.202052301
B01 - Kashkar - Abstract
Llamas, E., Torres-Montilla, S., Lee, H. J., Barja, M. V., Schlimgen, E., Dunken, N., Wagle, P., Werr, W., Zuccaro, A., Rodríguez-Concepción, M., & Vilchez, D (2021). The intrinsic chaperone network of Arabidopsis stem cells confers protection against proteotoxic stress. Aging Cell, 00, e13446. https://doi.org/10.1111/acel.13446
B03 - Zuccaro - Abstract
Hepowit, N.L., Kolbe, C.-C., Zelle, S.R., Latz, E., MacGurn, J.A. (2021) Regulation of Ubiquitin and Ubiquitin-like Modifiers by Phosphorylation. The FEBS Journal 02 July 2021https://doi.org/10.1111/febs.16101
A04 - Latz
Sun, X., Lapin, D., Feehan, J.M., Stolze, S.C., Kramer, K., Dongus, J.A., Rzemieniewski, J., Blanvillain-Baufumé, S., Harzen, A., Bautor, J., Derbyshire, P., Menke, F.L.H., Finkemeier, I., Nakagami, H., Jones, J.D.G., & Parker, J.E.(2021) Pathogen effector recognition-dependent association of NRG1 with EDS1 and SAG101 in TNL receptor immunity. Nature Communications 12, Article number: 3335 https://doi.org/10.1038/s41467-021-23614-x
B08 - Parker - Abstract
Alvarez, C.R., Kee, C., Sharma, A.,K., Thomas, L., Schmidt, F.I., Stanifer, M.L., Boulant, S., Herrmann, C. (2021) The endogenous cellular protease inhibitor SPINT2 controls SARS-CoV-2 viral infection and is associated to disease severity. PLOS Pathogens June 28, 2021 https://doi.org/10.1371/journal.ppat.1009687
A04 - Schmidt - Abstract
Theobald, S.J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H.S., Albert, M.C., Chhen, J., Motameny, S., Erger, F., Fischer, J., Malin, J.J., Gräb, J., Winter, S., Pouikli, A., David, F., Böll, B., Koehler, P., Vanshylla, K., Gruell, H., Suárez, I., Hallek, M., Fätkenheuer, G., Jung, N., Cornely, O.A., Lehmann, C., Tessarz, P., Altmüller, J., Nürnberg, P., Kashkar, H., Klein, F., Koch, M., and Rybniker, J. (2021) Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med e14150https://doi.org/10.15252/emmm.202114150
B05 - Rybniker & B01 - Kashkar - Abstract
Oikonomou, N., Schuijs, M.J., Chatzigiagkos, A., Androulidaki, A., Aidinis, V., Hammad, H., Lambrecht, B.N., and Pasparakis, M. (2021) Airway epithelial cell necroptosis contributes to asthma exacerbation in a mouse model of house dust mite-induced allergic inflammation. Mucosal Immunology https://doi.org/10.1038/s41385-021-00415-5
A01 - Pasparakis - Abstract
Hadrian, K., Willenborg, S., Bock, F., Cursiefen, C., Eming, S.A., and Hos, D. (2021). Macrophage-Mediated Tissue Vascularization: Similarities and Differences Between Cornea and Skin. Front. Immunol., 07 April 2021 | https://doi.org/10.3389/fimmu.2021.667830
A07 - Eming - Abstract
Sprenger, H.G., MacVicar, T., Bahat, A., Fiedler, K.U., Hermans, S., Ehrentraut, D., Ried, K., Milenkovic, D., Bonekamp, N., Larsson, N.G., Nolte, H., Giavalisco, P. & Langer. T. (2021) Cellular pyrimidine imbalance triggers mitochondrial DNA–dependent innate immunity. Nature Metabolism 26.04.2021 https://doi.org/10.1038/s42255-021-00385-9
A06 - Langer - Abstract
Kumari, S., Van, T.-M., Preukschat, D., Schuenke, H., Basic, M., Bleich, A., Klein, U., Pasparakis, M. (2021) NF-κB inhibition in keratinocytes causes RIPK1-mediated necroptosis and skin inflammation. Life Science Alliance 15 April 2021. DOI: 10.26508/lsa.202000956
A01 - Pasparakis - Abstract
Bebber, C.M., Thomas, E.S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M.N., Stüker, L., de Pádua Alves,C., Khonsari, A., Dammert, M.A., Parmaksiz, F., Tumbrink, H.L., Beleggia, F., Sos, M.L., Riemer, J., George, J., Brodesser, S., Thomas, R.K., Reinhardt, H.C. & von Karstedt, S. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications volume 12, Article number: 2048. https://doi.org/10.1038/s41467-021-22336-4
A05 - von Karstedt - Abstract
Bauernfried. S., & Hornung, V. (2021) DPP9 restrains NLRP1 activation. Nat Struct Mol Biol. https://doi.org/10.1038/s41594-021-00580-y
A03 - Hornung - Abstract
Xing, Y., Xu, N., Bhandari, D.,D., Lapin, D., Sun, X., Luo, X., Wang, Y., Cao, J., Wang, H., Coaker, G., Parker, J.,E., Liu, J. Bacterial effector targeting of a plant iron sensor facilitates iron acquisition and pathogen colonization. The Plant Cell Koab075 https://doi.org/10.1093/plcell/koab075
B08 - Parker - Abstract
Mooney, B. C., Mantz, M., Graciet, E, Huesgen, P. F. (2021) Cutting the line: manipulation of plant immunity by bacterial type III effector proteases. J Exp Bot doi:10.1093/jxb/erab095
B02 - Huesgen - Abstract
Zhao, C., Tang, Y., Wang. J., Zeng, Y., Sun, H., Zheng, Z., Su, R., Schneeberger, K., Parker, J.E., Cui, H. (2021) A mis‐regulated cyclic nucleotide‐gated channel mediates cytosolic calcium elevation and activates immunity in Arabidopsis. New Phytologist doi:10.1111/nph.17218
B08 - Parker - Abstract
Bauer, S., Yu, D., Lawson, A.W., Saur, I.M.L., Frantzeskakis, L., Kracher, B., Logemann, E., Chai, J., Maekawa, T., Schulze-Lefert, P. (2021) The leucine-rich repeats in allelic barley MLA immune receptors define specificity towards sequence-unrelated powdery mildew avirulence effectors with a predicted common RNase-like fold. PLoS Pathog 17(2): e1009223. doi:10.1371/journal.ppat.1009223
B08 - Schulze-Lefert & Maekawa & Chai - Abstract
Koenig,P.-A., Das, H., Liu, H., Kümmerer, B. M., Gohr, F. N., Jenster, L.-N., Schiffelers, L. D. J., Tesfamariam, Y. M., Uchima, M., Wuerth, J. D., Gatterdam, K., Ruetalo, N., Christensen, M., H., Fandrey, C. I., Normann, S., Tödtmann, J. M. P., Pritzl, S., Hanke, L., Boos, J., Yuan, M., Zhu, X., Schmid-Burgk, J.-L., Kato, H., Schindler, M., Wilson, I. A., Geyer, M., Ludwig, K. U., Hällberg, B. M., Wu, N. C., Schmidt, F. I. (2021) Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape. Science 2021 Jan 12:eabe6230. doi: 10.1126/
A04 - Schmidt - Abstract
Mellis, A-T., Misko, A.L., Arjune, S., Liang, Y., Erdélyi, K., Ditrói, T., Kaczmarek, A.T., Nagy, P., Schwarz, G. (2021) The role of glutamate oxaloacetate transaminases in sulfite biosynthesis and H2S metabolism. Redox Biology Volume 38 2021, https://doi.org/10.1016/j.redox.2020.101800
A08 - Schwarz - Abstract
2020
Pinci, F., Gaidt, M. M., Jung,C., Kuut, G., Jackson, M. A., Bauernfried, S., and Hornung, V. (2020) C-tag TNF: a reporter system to study TNF shedding. Journal of Biological Chemistry Vol 295, Issue 52. DOI 10.1074/jbc.RA120.015248
A03 - Hornung - Read more
Pedrera, L., Espiritu, R., A., Ros, U., Weber, J., Schmitt, A., Stroh, J., Hailfinger, S., von Karstedt, S., García-Sáez, A., J. (2020) Ferroptotic pores induce Ca 2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ Dec 17. doi: 10.1038/s41418-020-00691-x
A02 - Garcia-Saez - Read more
Ma, S., Lapin, D., Liu, L., Sun, Y., Song, W., Zhang, X., Logemann, E., Yu, D., Wang, J., Jirschitzka, J., Han, Z., Schulze-Lefert, P., Parker, J.E., Chai, J. (2020) Direct pathogen-induced assembly of an NLR immune receptor complex to form a holoenzyme. Science Vol. 370, Issue 6521, eabe3069; https://doi.org/10.1126/science.abe3069
B08 - Chai, Parker and Schulze Lefert - Read more
Flores‐Romero, H., Ros, U., Garcia-Saez, A.J. (2020) Pore formation in regulated cell death. EMBO J (2020)e105753 https://doi.org/10.15252/embj.2020105753
A02 - Garcia-Saez - Read more
Clemente, L.P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J., Culmsee, C., von Karstedt, S. (2020) Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells Oct 9;9(10):E2259. doi: 10.3390/cells9102259
A05 - von Karstedt - Read more
Mahdi, L.K., Huang, M., Zhang, X., Nakano, R.T., Kopp, L.B., Saur, I.M.L., Jacob, F., Kovacova, V., Lapin, D., Parker, J.E., Murphy, J.M., Hofmann, K., Schulze-Lefert, P., Chai, J., Maekawa, T. (2020) Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling. Cell Host & Microbe https://doi.org/10.1016/j.chom.2020.08.012
B07 - Maekawa, Chai & B08 - Schulze-Lefert & B06 Hofmann - Read more
Mayer, C.T., Nieke, J.P., Gazumyan, A., Cipolla, M., Wang, Q., Oliveira, Y.T., Ramos, V., Monette, S., Li, Q.Z., Gershwin, M.E., Kashkar, H., Nussenzweig, M.C. (2020) An apoptosis-dependent checkpoint for autoimmunity in memory B and plasma cells. Proc Natl Acad Sci U S A [Epub ahead of print] https://doi.org/10.1073/pnas.2015372117
B01 - Kashkar - Read more
Albert, M.C., Brinkmann, K., Pokrzywa, W., Günther, S.D., Krönke, M., Hoppe, T. & Kashkar, H. (2020). CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis 11, 740. https://doi.org/10.1038/s41419-020-02923-x
B01 - Kashkar - Read more
Schiffmann, L.M., Werthenbach, J.P., Heintges-Kleinhofer, F., Seeger, J.M., Fritsch, M., Günther, S.D., Willenborg,S., Brodesser,S., Lucas, C. Jüngst, C., Albert, M.C., Schorn, F.,Witt, A., Moraes, C.T., Bruns, C.J., Pasparakis, M., Krönke, M., Eming, S.A., Coutelle, O., Kashkar, H. (2020). Mitochondrial respiration controls neoangiogenesis during wound healing and tumour growth. Nat Comm. Volume 11, Article Number: 3653. https://doi.org/10.1038/s41467-020-17472-2
B01 - Kashkar & A07 - Eming & A01 - Pasparakis - Read more
Laurien, L., Nagata, M., Schünke, H., Delanghe, T., Wiederstein, J., L., Kumari, S., Schwarzer, R., Corona, T., Krüger, M., Bertrand, M., J., M., Kondylis, V. & Pasparakis, M.(2020). Autophosphorylation at serine 166 regulates RIP kinase 1-mediated cell death and inflammation. Nat. Comm. Volume 11, Article number: 1747. https://doi.org/10.1038/s41467-020-15466-8
A01 - Pasparakis - Read more.
Schwarzer, R., Jiao, H., Wachsmuth, L., Tresch, A., Pasparakis, M.(2020). FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity Volume 52, Pages 1-16. https://doi.org/10.1016/j.immuni.2020.04.002 For free acces please go here
A01 - Pasparakis - Read more.
Schwarzer, R., Laurien, L., Pasparakis, M. (2020). New insights into the regulation of apoptosis, necroptosis, and pyroptosis by receptor interacting protein kinase 1 and caspase-8. Curr. Opin. Cell Biol. Volume 63, Pages 186-193. https://doi.org/10.1016/j.ceb.2020.02.004
A01 - Pasparakis - Read more.
Jiao, H., Wachsmuth, L., Kumari, S., Schwarzer, R., Lin, J., Eren, R., O., Fisher, A., Lane, R., Young, G., R., Kassiotis, G., Kaiser W., J., Pasparakis, M. (2020). Z-nucleic-acid sensing triggers ZBP1dependent necroptosis and inflammation. Nature, https://doi.org/10.1038/s41586-020-2129-8
A01 - Pasparakis - Read more.
Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H. (2020) Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide. Nat. Microbiol. 5:354–367.
B01 - Kashkar & A03 - Hornung - Read more