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Christ, A., Latz, E.

Deciphering How NLRP3 Incites the Stromal Response in Kawasaki Vasculitis


Kawasaki disease (KD), also known as Kawasaki syn-drome, is one of the most common acute vasculitides in children. KD is typically a febrile self-limited illness that, if untreated, can lead to coronary artery aneurysms that can ultimately result in accelerated atherosclerosis, myocardial  infarction,  and  resultant  heart  failure.  The  disease, described initially by Tomisaku Kawasaki in the 1960s1,2  is  clinically  accompanied  by  fever  lasting  >5  days  and  signs  of  mucocutaneous  inflammation.  These  physical findings, which often do not appear simultane-ously, include bilateral nonexudative conjunctivitis, rashes, mucositis, cervical lymphadenopathy, and changes at the extremities, such as palmar or plantar erythema. In about 40%  of  children  with  KD,  a  concurrent  infection  can  be  diagnosed  at  the  clinical  presentation,  which  makes  determining the cause of fever particularly challenging.

Read more at Circulation Research