Research Projects of CRC1403
The individual projects are grouped into two research areas focusing on, (A) cell death in
inflammation and disease, and (B) cell death mechanisms in host defence. The projects
in the two research areas share a common focus on the mechanisms regulating and sensing cell
death and the functional implications of different types of RCD at the tissue and organismal level.
Therefore, the two research areas will be connected by multiple points of interaction related to the
induction, execution and sensing of RCD, as well as the local and systemic effects of cell death.
Research Area A: Cell death in inflammation and disease
A01 - Mechanisms of cell death-induced inflammation
A02 - Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach
A03 - Identification of molecules and key pathways that drive necroptosis-dependent inflammation
A04 - Cellular responses to and molecular pathways of macrophage pyroptosis
A05 - Inflammatory signalling in ferroptotic cell death
A06 - Mitochondrial YME1L at the interface of cell death and inflammation
A07 - Control of macrophage cell death in skin homeostasis and repair
A08 - Ferroptosis and regulated cell death in sulphite oxidase deficiency
A09 - Regulated cell death and kidney fibrosis as a consequence of mutation of cilia-associated genes
Research Area B: Cell death mechanisms in host defence
B01 - Role of apoptotic caspases in macrophage-mediated anti-bacterial immunity
B02 - Signals and substrates of cell death proteases in plant – microbe interactions
B03 - Cell death regulation and function in plant-fungal symbiosis
B05 - Mechanisms and consequences of myeloid cell death induced by Mycobacterium tuberculosis
B06 - The evolution of regulated necrotic cell death
B07 - Structural and functional study of mixed lineage kinase domain-like proteins in plants and animals
B08 - Connecting plant sensor NLRs to host cell death responses
Central Projects
CP01 - Central Tasks
CP03 - Cell Death Assessment Unit
IRTG - Integrated Research Training Group (“Cell-Death-RTG”)
Junior Research Groups
Christina Ising - Microglia pyroptosis in Alzheimer’s disease