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Sonderforschungsbereich 1403

Research Projects of CRC1403

The individual projects are grouped into two research areas focusing on, (A) cell death in
inflammation and disease, and (B) cell death mechanisms in host defence. The projects
in the two research areas share a common focus on the mechanisms regulating and sensing cell
death and the functional implications of different types of RCD at the tissue and organismal level.
Therefore, the two research areas will be connected by multiple points of interaction related to the
induction, execution and sensing of RCD, as well as the local and systemic effects of cell death.

Research Area A: Cell death in inflammation and disease

A01 - Mechanisms of cell death-induced inflammation

A02 - Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach

A03 - The role of metalloprotease activity in necroptosis driven inflammation

A04 - Molecular pathways of gasdermin pore formation and repair

A05 - Inflammatory signalling in ferroptotic cell death

A06 - The role of mitochondria for cellular protection against ferroptosis

A07 - Control of macrophage cell death in skin homeostasis and repair

A09 - Regulated cell death and kidney fibrosis as a consequence of mutation of cilia-associated genes

A10 - Cell death and inflammation modulated by the ubiquitin E3 ligase activities within LUBAC in metabolic inflammation

A11 - NLRP10 inflammasome mediated anti-inflammatory cell death

A12 - The role of a new E3 ligase in regulating cell death and inflammation in immune signaling

A13 - Contribution of microglia cell death to tau pathology in Alzheimer’s disease and other tauopathies

A14 - Immunological dissection of cell death-induced inflammation in human disease

Research Area B: Cell death mechanisms in host defence

B01 - Role of apoptotic caspases in macrophage-mediated anti-bacterial immunity

B02 - Cell death signalling peptides in maize immunity – Molecular mechanisms of signal generation, transduction and perception

B03 - Cell death regulation and function in plant-fungal symbiosis

B05 - Mechanisms and consequences of inflammasome mediated mitochondrial impairment in Mycobacterium tuberculosis infected myeloid cells

B06 - The evolution of regulated necrotic cell death

B07 - Ultra-structure of the plasma membrane harbouring MLKL oligomers and MLKL-mediated Ca2+ influx during plant and animal immunogenic cell death

B08 - Connecting plant TIR-domain NLR receptors to host cell death and pathogen resistance

B09 - Immune-related cell death pathways as targets of fungal virulence strategies

Central Projects

CP01 - Central Tasks

CP02 - Genetically engineered mouse models for the study of cell death and its role in immunity and inflammation

CP03 - Cell Death Assessment Unit

CP04 - Proteomic dissection of cell death-mediated protein release and proteolysis

INF - Research data management, analysis and bioinformatics support

IRTG - Integrated Research Training Group (“Cell-Death-RTG”)

Associated Groups

Alessandro Annibaldi

Paul Schulze-Lefert

Esther von Stebut-Borschitz

Ended Projects 2020 - 2023

A08 - Ferroptosis and regulated cell death in sulphite oxidase deficiency