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A03 - Identification of molecules and key pathways that drive necroptosis-dependent inflammation

Veit Hornung

Gene Center Munich, Department for Biochemistry, Ludwig-Maximilians-University Munich
Contact: hornungSpamProtectiongenzentrum.lmu.de
For more information visit: Hornung lab

Abstract

Unlike apoptosis, necroptosis results in the release of cytosolic contents that are believed to induce inflammation. Using a well-established in vitro model of human cells, this project aims to characterise necroptosis-driven inflammation in vitro and to identify necroptosis-dependent DAMP or alarmin molecules. By systematically perturbing all known PRR- and cytokine receptor-dependent signalling cascades within bystander cells this project will additionally characterise the dominant sensing modalities in this setting. These efforts will provide novel mechanistic insights into how necroptosis triggers inflammation.

Recent Publications

2021

Bauernfried. S., & Hornung, V. (2021) DPP9 restrains NLRP1 activation. Nat Struct Mol Biol. https://doi.org/10.1038/s41594-021-00580-y

2020

Pinci, F., Gaidt, M. M., Jung,C., Kuut, G., Jackson, M. A., Bauernfried, S., and  Hornung, V. (2020) C-tag TNF: a reporter system to study TNF shedding. Journal of Biological Chemistry Vol 295, Issue 52. DOI 10.1074/jbc.RA120.015248

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