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A03 - The role of metalloprotease activity in necroptosis driven inflammation

Veit Hornung

Gene Center Munich, Department for Biochemistry, Ludwig-Maximilians-University Munich
Contact: hornung(at)genzentrum.lmu.de
For more information visit: Hornung lab


Unlike apoptosis, necroptosis results in the release of cytosolic contents that are believed to induce inflammation. Using a well-established in vitro model of human cells, this project aims to characterise necroptosis-driven inflammation in vitro and to identify necroptosis-dependent DAMP or alarmin molecules. By systematically perturbing all known PRR- and cytokine receptor-dependent signalling cascades within bystander cells this project will additionally characterise the dominant sensing modalities in this setting. These efforts will provide novel mechanistic insights into how necroptosis triggers inflammation.

Recent Publications

Project A03 Publications 2020-2023

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