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B08 - Connecting plant TIR-domain NLR receptors to host cell death and pathogen resistance

Jane Parker

Max Planck Institute for Plant Breeding Research
Contact: parker(at)mpipz.mpg.de
For more information visit: Parker lab


Nucleotide-binding domain/leucine-rich repeat (NLR) receptors provide a crucial barrier to pathogen infection in mammals and plants. We’re studying plant immune responses mediated by a major class of NLR receptor with N-terminal Toll-Interleukin1-Receptor (TIR) signalling domains. Pathogen-activated TIR-NLRs form oligomeric (resistosome) NADase enzymes which generate a suite of ribosylated nucleotide  second messengers. Specific nucleotides regulate distinct host localized cell death and defence stimulating branches, both associated with calcium influxes into host cells. Our aim is to characterize TIR-NLR triggered processes conferring regulated host cell death and cell -to - cell defence potentiation in leaves. 

Recent Publications


Song W, Liu L, Yu D, Bernardy H, Jirschitzka J, Huang S, Jia A, Jemielniak W, Acker J, Laessle H, Wang J, Shen Q, Chen W, Li P, Parker JE, Han Z, Schulze-Lefert P, Chai J. Substrate-induced condensation activates plant TIR domain proteins. Nature. 2024 Mar 13. doi: 10.1038/s41586-024-07183-9. Epub ahead of print. PMID: 38480885

Locci F and Parker JE* 2024. Plant NLR immunity activation and execution: a biochemical perspective. Open Biol. 14:230387. doi.org/10.1098/rsob.230387

Project B08 Publications 2020 - 2023

Project related Publications

Project B08 First funding period 2020 - 2023