B06 - The evolution of regulated necrotic cell death

Kay Hofmann

Institute for Genetics, University of Cologne
Contact: Kay.Hofmann(at)uni-koeln.de
For more information visit: Hofmann lab

Abstract

RCD pathways are found in many phyla, ranging from developmentally programmed apoptosis in animals to cell-autonomous programmed necrosis pathways that limit the spread of biotrophic pathogens in multicellular assemblies. This project builds on own previous results and expands on the inter-phylum comparison of cell death pathways. The central goal of this project is to understand how different necrotic signalling pathways evolved from a pre-existing set of ancient protein modules and later added lineage-specific sub-pathways leading to their functional diversification.

Recent Publications

Project B06 Publications 2nd Funding Period 2024 - 2027

Project B06 Publications 1st Funding Period 2020 - 2023

2020

Project related Publications

1999 - 2019

Seenivasan, R., Hermanns, T., Blyszcz, T., Lammers, M., Praefcke, G.J.K., and Hofmann, K. (2019) Mechanism and chain-specificity of RNF216/TRIAD3, the ubiquitin ligase mutated in Gordon-Holmes Syndrome. Hum. Mol. Genet., doi: 10.1093/hmg/ddz098

Hermanns, T., Pichlo, C., Woiwode, I., Klopffleisch, K., Witting, K.F., Ovaa, H., Baumann, U., and Hofmann, K. (2018). A family of unconventional deubiquitinases with modular chain specificity determinants. Nature Commun. 9, 799.

Daskalov, A., Habenstein, B., Sabaté, R., Berbon, M., Martinez, D., Chaignepain, S., Coulary-Salin, B., Hofmann, K., Loquet, A., and Saupe, S.J. (2016). Identification of a novel cell death-inducing domain reveals that fungal amyloid-controlled programmed cell death is related to necroptosis. Proc. Natl. Acad. Sci. U.S.A. 113, 2720-2705.

Kajava, A.V., Klopffleisch, K., Chen, S., and Hofmann, K. (2014). Evolutionary link between metazoan RHIM motif and prion-forming domain of fungal heterokaryon incompatibility factor HET-s/HET-s. Sci. Rep. 4, 7436.

Rebsamen, M., Heinz, L.X., Meylan, E., Michallet, M.C., Schroder, K., Hofmann, K., Vazquez, J., Benedict, C.A., and Tschopp, J. (2009). DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB. EMBO Rep. 10, 916-922.

Meylan, E., Burns, K., Hofmann, K., Blancheteau, V., Martinon, F., Kelliher, M., and Tschopp, J. (2004). RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation. Nat. Immunol. 5, 503-507.

Hofmann, K. (1999). The modular nature of apoptotic signaling proteins. Cell. Mol. Life Sci. 55,1113-1128.

Hofmann, K., and Dixit, V.M. (1998). Ceramide in apoptosis. Trends Biochem. Sci. 23, 374-377.

Hofmann, K., Bucher, P., and Tschopp, J. (1997). The CARD domain: a new apoptotic signalling motif. Trends Biochem. Sci. 22, 155-156.

Mahdi,L.K., Huang, M., Zhang, X., Nakano R.-T., Kopp, L.B., Saur, I. M.-L., Jacob, F., Kovacova, V., Lapin, D., Murphy, J., Parker, J., Hofmann, K., Schulze-Lefert. P, Chai. J., and T. Maekawa (2019). Plant mixed lineage kinase domain-like proteins limit biotrophic pathogen growth, BioRxiv https://doi.org/10.1101/681015

UNIVERSITÄT ZU KÖLN

Sonderforschungsbereich 1403