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B06 - The evolution of regulated necrotic cell death

Kay Hofmann

Institute for Genetics, University of Cologne
Contact: Kay.Hofmann(at)uni-koeln.de
For more information visit: Hofmann lab


RCD pathways are found in many phyla, ranging from developmentally programmed apoptosis in animals to cell-autonomous programmed necrosis pathways that limit the spread of biotrophic pathogens in multicellular assemblies. This project builds on own previous results and expands on the inter-phylum comparison of cell death pathways. The central goal of this project is to understand how different necrotic signalling pathways evolved from a pre-existing set of ancient protein modules and later added lineage-specific sub-pathways leading to their functional diversification.

Recent Publications


Mahdi, L.K., Huang, M., Zhang, X., Nakano, R.T., Kopp, L.B., Saur, I.M.L., Jacob, F., Kovacova, V., Lapin, D., Parker, J.E., Murphy, J.M., Hofmann, K., Schulze-Lefert, P., Chai, J., Maekawa, T. (2020) Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling. Cell Host & Microbe https://doi.org/10.1016/j.chom.2020.08.012

Project related Publications