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B06 - The evolution of regulated necrotic cell death

Kay Hofmann

Institute for Genetics, University of Cologne
Contact: Kay.HofmannSpamProtectionuni-koeln.de
For more information visit: Hofmann lab


RCD pathways are found in many phyla, ranging from developmentally programmed apoptosis in animals to cell-autonomous programmed necrosis pathways that limit the spread of biotrophic pathogens in multicellular assemblies. This project builds on own previous results and expands on the inter-phylum comparison of cell death pathways. The central goal of this project is to understand how different necrotic signalling pathways evolved from a pre-existing set of ancient protein modules and later added lineage-specific sub-pathways leading to their functional diversification.

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