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B07 - Ultra-structure of the plasma membrane harbouring MLKL oligomers and MLKL-mediated Ca2+ influx during plant and animal immunogenic cell death

Takaki Maekawa

The Institute for Plant Sciences, University of Cologne
Contact: takaki.maekawa(at)uni-koeln.de
For more information visit: Maekawa lab

Ana J. Garcia-Saez

Institute for genetics, CECAD, University of Cologne
Contact: garcia-office(at)uni-koeln.de
For more information see: Garcia-Saez lab


The discovery of a new protein family in seed plants that is structurally and functionally homologous to animal Mixed lineage kinase domain-like (MLKL) protein, the executioner of necroptosis in animal cells, provided evidence that similar mechanisms may induce plasma membrane permeabilisation in plants and animals. This project aims to understand the molecular principles of MLKL-mediated cell death and immunity by determining and comparing the nanoscale organisation and cellular dynamics of this protein family in plant and animal cells.

Recent Publications


Shen Q, Hasegawa K, Oelerich N, Prakken A, Tersch LW, Wang J, Reichhardt F, Tersch A, Choo JC, Timmers T, Hofmann K, Parker JE, Chai J, Maekawa T. Cytoplasmic calcium influx mediated by plant MLKLs confers TNL-triggered immunity. Cell Host Microbe. 2024 Mar 13:S1931-3128(24)00059-3. doi: 10.1016/j.chom.2024.02.016. Epub ahead of print. PMID: 38513655.

Project B07 Publications 2020 - 2023

Project related Publications

Project B07 First funding period 2020 - 2023