Próchnicki, T., Vasconcelos, M.B., Robinson, K.S., Mangan, M.S.J., De Graaf, D., Shkarina, K., Lovotti, M., Standke, L., Kaiser, R., Stahl, R., Duthie, F.G., Rothe, M., Antonova, K., Jenster, L.M., Lau, Z.H., Rösing, S., Mirza, N., Gottschild, C., Wachten, D., Günther, C., Kufer, T.A., Schmidt, F.I., Zhong, F.L., and Latz, E. (2023). Mitochondrial damage activates the NLRP10 inflammasome. Nat Immunol. 24, 595-603
Zhen,. D., Mohapatra, G., Kern, L., He, Y., Shmueli, M.D., Valdés-Mas, R., Kolodziejczyk, A., Próchnicki, T., Vasconcelos, M.B., Puschhof, J., Schorr, L., Hertel, F., Camacho, M., Cheddaha, C.M., Shimshy, S., Hodgetts, R.J., Dori-Bachash, M., Kleimeyer, C., Goldenberg, K., Heinemann, M., Stettner, N., Harmelin, A., Shapiro, H., Chen, M., Abdeen, S.K., Latz, E., Merbl, Y., and Elinav, E. (2023). Epithelial Nlrp10 inflammasome mediates protection against intestinal autoinflammation. Nat Immunol. 24, 585-594
Budden, C.F., Gearing, L.J., Kaiser, R., Standke, L., Hertzog, P.J., and Latz, E. (2021). Inflammasome-induced extracellular vesicles harbor distinct RNA signatures and alter bystander macrophage responses. J Extracell Vesicles. 10, e12127.
Hochheiser, I.V., Pilsl, M., Hagelueken, G., Moecking, J., Marleaux, M., Brinkschulte, R., Latz, E, Engel, C., and Geyer, M. (2022). Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3. Nature 604, 184-189.
Hoss, F., Mueller, J.L., Rojas Ringeling, F., Rodriguez-Alcazar, J.F., Brinkschulte, R., Seifert, G., Stahl, R., Broderick, L., Putnam, C.D., Kolodner, R.D., Canzar, S., Geyer, M., Hoffman, H.M., and Latz, E. (2019). Alternative splicing regulates stochastic NLRP3 activity. Nat Commun.10, 3238.
Christ, A., Gunther, P., Lauterbach, M.A.R., Duewell, P., Biswas, D., Pelka, K., Scholz, C.J., Oosting, M., Haendler, K., Baßler, K., Klee, K., Schulte-Schrepping, J., Ulas, T., Moorlag, S.J.C.F.M., Kumar, V., Park, M.H., Joosten, L.A.B., Groh, L.A., Riksen, N.P., Espevik, T., Schlitzer, A., Li, Y., Fitzgerald, M.L., Netea, M.G., Schultze, J.L., and Latz, E. (2018). Western diet triggers NLRP3-dependent innate immune reprogramming. Cell 172, 162-175.
Stutz, A., Kolbe, C.C., Stahl, R., Horvath, G.L., Franklin, B.S., van Ray, O., Brinkschulte, R., Geyer, M., Meissner, F., and Latz, E. (2017). NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain. J Exp Med. 214, 1725-1736.
Franklin, B.S., Bossaller, L., De Nardo, D., Ratter, J.M., Stutz, A., Engels, G., Brenker, C., Nordhoff, M., Mirandola, S.R., Al-Amoudi, A., Mangan, M.S., Zimmer, S., Monks, B.G., Fricke, M., Schmidt, R.E., Espevik, T., Jones, B., Jarnicki, A.G., Hansbro, P.M., Busto, P., Marshak-Rothstein, A., Hornemann, S., Aguzzi, A., Kastenmuller, W., and Latz, E. (2014). The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat. Immunol.15, 727-737.
Duewell, P., Kono, H., Rayner, K.J., Sirois, C.M., Vladimer, G., Bauernfeind, F.G., Abela, G.S., Franchi, L., Nunez, G., Schnurr, M., Espevik, T., Lien, E., Fitzgerald, K.A., Rock, K.L., Moore, K.J., Wright, S.D., Hornung, V., and Latz, E. (2010). NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361.
