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A11 - NLRP10 inflammasome mediated anti-inflammatory cell death

Eicke Latz

Institute of Innate Immunity, University Hospital Bonn, University of Bonn
Contact: eicke.latz(at)uni-bonn.de
For more information visit: Latz Lab

Abstract

This project is funded within the 2nd funding period of the SFB 1403, starting from 2024

Recent Publications

2024

Wang W, Dernst A, Martin B, Lorenzi L, Cadefau-Fabregat M, Phulphagar K, Wagener A, Budden C, Stair N, Wagner T, Färber H, Jaensch A, Stahl R, Duthie F, Schmidt SV, Coll RC, Meissner F, Cuartero S, Latz E, Mangan MSJ. Butyrate and propionate are microbial danger signals that activate the NLRP3 inflammasome in human macrophages upon TLR stimulation. Cell Rep. 2024 Sep 13;43(9):114736. doi: 10.1016/j.celrep.2024.114736. Epub ahead of print. PMID: 39277863.


Weiss FD, Alvarez Y, Shakeri F, Sahu A, Leka P, Dernst A, Rollheiser J, Vasconcelos M, Geraci A, Duthie F, Stahl R, Lee HE, Gellner AK, Buness A, Latz E, Meissner F. Retention of ES cell-derived 129S genome drives NLRP1 hypersensitivity and transcriptional deregulation in Nlrp3tm1Flv mice. Cell Death Differ. 2024 Sep 17. doi: 10.1038/s41418-024-01379-2. Epub ahead of print. PMID: 39289506.

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