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A02 – Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach

Ana J. Garcia-Saez

Institute for genetics, CECAD, University of Cologne
Contact: garcia-office(at)uni-koeln.de
For more information see: Garcia-Saez lab

Manolis Pasparakis

Institute for genetics, CECAD, University of Cologne
Contact: pasparakis(at)uni-koeln.de
For more information see: Pasparakis lab

Abstract

Currently available tools do not allow studying the cross-talk between dying and bystander cells in a spatially and temporally resolved manner. The project aims to develop optogenetically regulated systems allowing the precisely controlled induction of different forms of cell death at a single cell level and use them to study the cross-talk between dying and bystander cells in vitro and in vivo. By employing selective light-controlled activation of different death effectors, this project will study how the different types of cell death shape tissue responses and the underlying mechanisms.

Recent Publications

Project A02 Publications 2020-2023

Project related Publications