A02 – Cross-talk between dying and bystander cells in vitro and in vivo: an optogenetics approach
Ana J. Garcia-Saez
Currently available tools do not allow studying the cross-talk between dying and bystander cells in a spatially and temporally resolved manner. The project aims to develop optogenetically regulated systems allowing the precisely controlled induction of different forms of cell death at a single cell level and use them to study the cross-talk between dying and bystander cells in vitro and in vivo. By employing selective light-controlled activation of different death effectors, this project will study how the different types of cell death shape tissue responses and the underlying mechanisms.
Pedrera, L., Espiritu, R., A., Ros, U., Weber, J., Schmitt, A., Stroh, J., Hailfinger, S., von Karstedt, S., García-Sáez, A., J. (2020) Ferroptotic pores induce Ca 2+ fluxes and ESCRT-III activation to modulate cell death kinetics. Cell Death Differ Dec 17. doi: 10.1038/s41418-020-00691-x