B03 - Zuccaro

B03 - Cell death regulation and function in plant-fungal symbiosis

Alga Zuccaro

Department of Botany, CEPLAS, University of Cologne
Contact: azuccaro(at)uni-koeln.de
For more information visit: Zuccaro lab

Abstract

Colonisation of plant roots by the beneficial fungal endophyte Serendipita indica involves a biotrophic phase and a host cell death phase characterised by production of deoxyadenosine (dAdo). This project will dissect plant immunity and cell death mechanisms induced by dAdo during fungal accommodation and the associated signalling pathways. We aim to elucidate how manipulation of particular plant cell death processes interferes with fungal accommodation and beneficial effects and whether these converge on a common core machinery for cell death control in plant roots.

Recent Publications

Project B03 Publications 2020-2023

2021

2023

Llamas, E., Koyuncu, S., Lee, H.J., Wehrmann, M., Gutierrez-Garcia, R., Dunken, N., Charura, N., Torres-Montilla, S., Schlimgen, E., Mandel, A.M., Theile, E.B., Grossbach, J., Wagle, P., Lackmann, J.W., Schermer, B., Benzing, T., Beyer, A., Pulido, P., Rodriguez-Concepcion, M., Zuccaro, A. and Vilchez, D. (2023) In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation. Nat Aging. doi: 10.1038/s43587-023-00502-1

Project related Publications

2011 - 2019

Wawra, S., Fesel, P., Widmer, H., Neumann, U., Lahrmann, U., Becker, S., Hehemann, J.H., Langen, G., and Zuccaro, A. (2019). FGB1 and WSC3 are in planta-induced beta-glucan-binding fungal lectins with different functions. New Phytol 222, 1493-1506.

Nizam, S., Qiang, X., Wawra, S., Nostadt, R., Getzke, F., Schwanke, F., Dreyer, I., Langen, G., and Zuccaro, A. (2019). Serendipita indica E5'NT modulates extracellular nucleotide levels in the plant apoplast and affects fungal colonization. EMBO Rep 20, e47430

Wawra, S., Fesel, P., Widmer, H., Timm, M., Seibel, J., Leson, L., Kesseler, L., Nostadt, R., Hilbert, M., Langen, G., and Zuccaro, A. (2016). The fungal-specific beta-glucan-binding lectin FGB1 alters cell-wall composition and suppresses glucan-triggered immunity in plants. Nature commun 7, 13188.

Fesel, P.H., and Zuccaro, A. (2016). Dissecting endophytic lifestyle along the parasitism/mutualism continuum in Arabidopsis. Curr Opin Microbiol 32, 103-112.

Lo Presti, L., Lanver, D., Schweizer, G., Tanaka, S., Liang, L., Tollot, M., Zuccaro, A., Reissmann, S., Kahmann, R., and Merchant, S. (2015). Fungal Effectors and Plant Susceptibility. Annu Rev Plant Biol 66, 513-545.

Lahrmann, U., Strehmel, N., Langen, G., Frerigmann, H., Leson, L., Ding, Y., Scheel, D., Herklotz, S., Hilbert, M., and Zuccaro, A. (2015). Mutualistic root endophytism is not associated with the reduction of saprotrophic traits and requires a noncompromised plant innate immunity. New Phytol 207, 841-857.

Zuccaro, A., Lahrmann, U., and Langen, G. (2014). Broad compatibility in fungal root symbioses. Curr Opin Plant Biol 20, 135-145.

Lahrmann, U., Ding, Y., Banhara, A., Rath, M., Hajirezaei, M.R., Doehlemann, S., von Wiren, N., Parniske, M., and Zuccaro, A. (2013). Host-related metabolic cues affect colonization strategies of a root endophyte. Proc Natl Acad Sci USA 110, 13965-13970.

Lahrmann, U., and Zuccaro, A. (2012). Opprimo ergo sum-Evasion and Suppression in the Root Endophytic Fungus Piriformospora indica. Mol Plant Microbe Interact 25, 727-737.

Zuccaro, A., Lahrmann, U., Gueldener, U., Langen, G., Pfiffi, S., Biedenkopf, D., Wong, P., Samans, B., Grimm, C., Basiewicz, M., et al. (2011). Endophytic Life Strategies Decoded by Genome and Transcriptome Analyses of the Mutualistic Root Symbiont Piriformospora indica. Plos Pathog 7, e1002290.

UNIVERSITÄT ZU KÖLN

Sonderforschungsbereich 1403