UNIVERSITÄT ZU KÖLN

Theobald, S. J., Simonis, A., Mudler, J.M.,…, Walczak, H.,... , and Rybniker J. (2022). Spleen tyrosine kinase mediates innate and adaptive immune crosstalk in SARS-CoV-2 mRNA vaccination. EMBO Mol Med 14, e15888.

Jain, R., Zhao, K., Sheridan, J.M., Heinlein, M., Kupresanin, F., Abeysekera, W., Hall, C., Rickard, J., Bouillet, P., Walczak, H., Strasser, A., Silke, J., and Gray, D.H.D. (2021). Dual roles for LUBAC signaling in thymic epithelial cell development and survival. Cell Death Differ 28, 2946-2956.

Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A.-L., Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke, J., and Walczak, H. (2022). Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differ 29, 492–503.

Lafont, E., Draber, P., Rieser, E., Reichert, M., Kupka, S., de Miguel, D., Draberova, H., von Mässenhausen, A., Bhamra, A., Henderson, S., Wojdyla, K., Chalk, A., Surinova, S., Linkermann, A., and Walczak, H. (2018). TBK1 and IKKε prevent TNF-induced cell death by RIPK1 phosphorylation. Nat Cell Biol 20, 1389–1399.

Peltzer, N., Darding, M., Montinaro, A., Draber, P., Draberova, H., Kupka, S., Rieser, E., Fisher, A., Hutchinson, C., Taraborrelli, L., Hartwig, T., Lafont, E., Haas, T.L., Shimizu, Y., Böiers, C., Sarr, A., Rickard, J., Alvarez-Diaz, S., Ashworth, M.T., Beal, A., Enver, T., Bertin, J., Kaiser, W., Strasser, A., Silke, J., Bouillet, P., and Walczak, H. (2018). LUBAC is essential for embryogenesis by preventing cell death and enabling haematopoiesis. Nature 557, 112–117.

Hartwig, T., Montinaro, A., von Karstedt, S., Sevko, A., Surinova, S., Chakravarthy, A., Taraborrelli, L., Draber, P., Lafont, E., Arce Vargas, F., El-Bahrawy, M.A., Quezada, S.A., and Walczak, H. (2017). The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol Cell 65, 730-742.e5.

Zinngrebe, J., Rieser, E., Taraborrelli, L., Peltzer, N., Hartwig, T., Ren, H., Kovács, I., Endres, C., Draber, P., Darding, M., von Karstedt, S., Lemke, J., Dome, B., Bergmann, M., Ferguson, B.J., and Walczak, H. (2016). LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation. J Exp Med 213, 2671–2689.

Kupka, S., De Miguel, D., Draber, P., Martino, L., Surinova, S., Rittinger, K., and Walczak, H. (2016). SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes. Cell Rep 16, 2271–2280.

Draber, P., Kupka, S., Reichert, M., Draberova, H., Lafont, E., de Miguel, D., Spilgies, L., Surinova, S., Taraborrelli, L., Hartwig, T., Rieser, E., Martino, L., Rittinger, K., and Walczak, H. (2015). LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes. Cell Rep 13, 2258–2272.

Gerlach, B., Cordier, S.M., Schmukle, A.C., Emmerich, C.H., Rieser, E., Haas, T.L., Webb, A.I., Rickard, J.A., Anderton, H., Wong, W.W.-L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A.W., Silke, J., and Walczak, H. (2011). Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471, 591–596.

Patents:

“A method for treating diseases of acute organ failure, including those caused by airway targeting viruses, such as Acute Respiratory Distress Syndrome, and related diseases”. UCL Business PLC; Filed: 18/10/20. Inventors: H. Walczak, N. Peltzer, et al..,

“A method for treating diseases by combined inhibition of TNF superfamily members and/or cell death signalling pathways” UCL Business PLC; Filed: 22/01/18, Inventors: H. Walczak, N. Peltzer, L. Taraborrelli. “Allosteric regulation of MLKL activity and inhibitors thereof” UCL Business PLC/University of Tübingen. Inventors: A. Garcia Saez, … H. Walczak*, N. Peltzer* (*equal contribution)