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A01 - Mechanisms of cell death-induced inflammation

Manolis Pasparakis

Institute for genetics, CECAD, University of Cologne
Contact: pasparakis(at)uni-koeln.de
For more information visit: Pasparakis lab

Abstract

Studies in mouse models provided evidence that cell death triggers inflammation, however the underlying mechanisms remain elusive. Using relevant genetic mouse models, this project will study the mechanisms by which different types of cell death trigger inflammation in vivo, focusing primarily on apoptosis and necroptosis. Major focus areas will be the in vivo role of specific DAMPs and their receptors as well as the mechanisms determining DAMP release via plasma membrane permeabilisation and their functional consequences in triggering cell death-induced inflammation.

Recent Publications

2025

Ros U, Martinez-Osorio V, Valiente PA, Abdelwahab Y, Gojkovic M, Shalaby R, Zanna S, Saggau J, Wachsmuth L, Nemade HN, Zoeller J, Lottermoser H, Chen YG, Ibrahim M, Kelepouras K, Vasilikos L, Bedoya P, Espiritu RA, Müller S, Altmannova V, Tieleman DP, Weir J, Langer J, Adam M, Walczak H, Wong WW, Liccardi G, Mollenhauer M, Pasparakis M, Peltzer N, García-Sáez AJ. MLKL activity requires a splicing-regulated, druggable intramolecular interaction. Mol Cell. 2025 Apr 3:S1097-2765(25)00259-X.  doi: 10.1016/j.molcel.2025.03.015. Epub vor dem Druck. PMID: 40209701

Project A01 Publications 2nd Funding Period 2024 - 2027

Project A01 Publications 1st Funding Period 2020 - 2023

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