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B05 - Mechanisms and consequences of inflammasome mediated mitochondrial impairment in Mycobacterium tuberculosis infected myeloid cells

Jan Rybniker

Clinic I for internal medicine, University of Cologne
Contact: jan.rybniker(at)uk-koeln.de
For more information visit: Rybniker lab


Mycobacterium tuberculosis (Mtb) is a highly successful intracellular pathogen based on its ability to manipulate innate immunity countermeasures of its major host, the human macrophage. Lytic host cell death is essential for bacterial dissemination and represents an important research topic both mechanistically and from a therapeutic perspective. This project aims to study how Mtb modulates regulated cell death in myeloid cells and to address the functional role of different cell death pathways in Mtb infection.

Recent Publications


Albert MC, Uranga-Murillo I, Arias M, De Miguel D, Peña N, Montinaro A, Varanda AB, Theobald SJ, Areso I, Saggau J, Koch M, Liccardi G, Peltzer N, Rybniker J, Hurtado-Guerrero R, Merino P, Monzón M, Badiola JJ, Reindl-Schwaighofer R, Sanz-Pamplona R, Cebollada-Solanas A, Megyesfalvi Z, Dome B, Secrier M, Hartmann B, Bergmann M, Pardo J, Walczak H. Identification of FasL as a crucial host factor driving COVID-19 pathology and lethality. Cell Death Differ. 2024 Mar 21. doi: 10.1038/s41418-024-01278-6. Epub ahead of print. PMID: 38514848

Knopf, J.D., Steigleder, S.S., Korn, F., Kühnle, N., Badenes, M., Tauber, M., Theobald, S.J., Rybniker, J., Adrain, C., and Lemberg, M.K.. (2024) RHBDL4-triggered downregulation of COPII adaptor protein TMED7 suppresses TLR4-mediated inflammatory signaling. Nat Commun. 15(1):1528. doi: 10.1038/s41467-024-45615-2.

Project B05 Publications 2020 - 2023

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