B05 - Mechanisms and consequences of myeloid cell death induced by Mycobacterium tuberculosis
Mycobacterium tuberculosis (Mtb) is a highly successful intracellular pathogen based on its ability to manipulate innate immunity countermeasures of its major host, the human macrophage. Lytic host cell death is essential for bacterial dissemination and represents an important research topic both mechanistically and from a therapeutic perspective. This project aims to study how Mtb modulates regulated cell death in myeloid cells and to address the functional role of different cell death pathways in Mtb infection.
Theobald, S.J., Simonis, A., Georgomanolis, T., Kreer, C., Zehner, M., Eisfeld, H.S., Albert, M.C., Chhen, J., Motameny, S., Erger, F., Fischer, J., Malin, J.J., Gräb, J., Winter, S., Pouikli, A., David, F., Böll, B., Koehler, P., Vanshylla, K., Gruell, H., Suárez, I., Hallek, M., Fätkenheuer, G., Jung, N., Cornely, O.A., Lehmann, C., Tessarz, P., Altmüller, J., Nürnberg, P., Kashkar, H., Klein, F., Koch, M., and Rybniker, J. (2021) Long-lived macrophage reprogramming drives spike protein-mediated inflammasome activation in COVID-19. EMBO Mol Med e14150https://doi.org/10.15252/emmm.202114150