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A05 - Inflammatory signalling in ferroptotic cell death

Silvia von Karstedt

Department of Translational Genomics, CECAD
Contact: s.vonkarstedt(at)uni-koeln.de
For more information visit: von Karstedt Lab


Ferroptosis is a newly described form of regulated necrosis independent of caspases and the necrosome, but dependent on ferrous iron that is accompanied by an inflammatory response. The identity of inflammatory mediators released from ferroptotic cells and how they might elicit an inflammatory response remain unknown. The project aims to achieve a first in-depth characterisation of ferroptotic DAMPs, characterise inflammatory signaling events relevant to bystander cells and to study the role of ferroptosis on immune cell activation in vivo.

Recent Publications


Yapici FI, Bebber CM, von Karstedt S. A guide to ferroptosis in cancer. Mol Oncol. 2024 Apr 8. doi: 10.1002/1878-0261.13649. Epub ahead of print. PMID: 38590214.

Project A05 Publications 2020-2023

Project related Publications