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A05 - Inflammatory signalling in ferroptotic cell death

Silvia von Karstedt

Department of Translational Genomics, CECAD
Contact: s.vonkarstedtSpamProtectionuni-koeln.de
For more information visit: von Karstedt Lab

Abstract

Ferroptosis is a newly described form of regulated necrosis independent of caspases and the necrosome, but dependent on ferrous iron that is accompanied by an inflammatory response. The identity of inflammatory mediators released from ferroptotic cells and how they might elicit an inflammatory response remain unknown. The project aims to achieve a first in-depth characterisation of ferroptotic DAMPs, characterise inflammatory signaling events relevant to bystander cells and to study the role of ferroptosis on immune cell activation in vivo.

Recent Publications

2021

Bebber, C.M., Thomas, E.S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M.N., Stüker, L., de Pádua Alves,C., Khonsari, A., Dammert, M.A., Parmaksiz, F., Tumbrink, H.L., Beleggia, F., Sos, M.L., Riemer, J., George, J., Brodesser, S., Thomas, R.K., Reinhardt, H.C. & von Karstedt, S. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications volume 12, Article number: 2048. https://doi.org/10.1038/s41467-021-22336-4

2020

Clemente, L.P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J., Culmsee, C., von Karstedt, S. (2020) Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells Oct 9;9(10):E2259. doi: 10.3390/cells9102259

Bebber, C.M., Müller, F., Clemente, L.P., Weber, J., von Karstedt, S., (2020). Ferroptosis in Cancer Cell Biology. Cancers (Basel) 2020 Jan; 12(1):164.

Project related Publications