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A05 - Inflammatory signalling in ferroptotic cell death

Silvia von Karstedt

Department of Translational Genomics, CECAD
Contact: s.vonkarstedt(at)uni-koeln.de
For more information visit: von Karstedt Lab

Abstract

Ferroptosis is a newly described form of regulated necrosis independent of caspases and the necrosome, but dependent on ferrous iron that is accompanied by an inflammatory response. The identity of inflammatory mediators released from ferroptotic cells and how they might elicit an inflammatory response remain unknown. The project aims to achieve a first in-depth characterisation of ferroptotic DAMPs, characterise inflammatory signaling events relevant to bystander cells and to study the role of ferroptosis on immune cell activation in vivo.

Recent Publications

2023

Müller, F., Lim, J.K.M., Bebber, C.M., Seidel, E., Tishina, S., Dahlhaus, A., Stroh, J., Beck, J., Yapici, F.I., Nakayama, K., Torres Fernández, L., Brägelmann, J., Leprivier, G., and von Karstedt, S. (2023. Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation. Cell Death Differ 30, 442-456. doi: 10.1038/s41418-022-01096-8.


2022

Seidel, E., & von Karstedt, S. (2022) Extrinsic cell death pathway plasticity: a driver of clonal evolution in cancer? Cell Death and Differentiation 8, Article number: 465 (review)


2021

Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A-L-, Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke J. & Walczak, H. (2021) Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differentiation. https://doi.org/10.1038/s41418-021-00869-x


Bebber, C.M., Thomas, E.S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M.N., Stüker, L., de Pádua Alves,C., Khonsari, A., Dammert, M.A., Parmaksiz, F., Tumbrink, H.L., Beleggia, F., Sos, M.L., Riemer, J., George, J., Brodesser, S., Thomas, R.K., Reinhardt, H.C. & von Karstedt, S. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications volume 12, Article number: 2048. https://doi.org/10.1038/s41467-021-22336-4

2020

Clemente, L.P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J., Culmsee, C., von Karstedt, S. (2020) Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells Oct 9;9(10):E2259. doi: 10.3390/cells9102259


Bebber, C.M., Müller, F., Clemente, L.P., Weber, J., von Karstedt, S., (2020). Ferroptosis in Cancer Cell Biology. Cancers (Basel) 2020 Jan; 12(1):164.

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