A05 - von Karstedt

A05 - Inflammatory signalling in ferroptotic cell death

Silvia von Karstedt

Department of Translational Genomics, CECAD
Contact: s.vonkarstedt(at)uni-koeln.de
For more information visit: von Karstedt Lab

Abstract

Ferroptosis is a newly described form of regulated necrosis independent of caspases and the necrosome, but dependent on ferrous iron that is accompanied by an inflammatory response. The identity of inflammatory mediators released from ferroptotic cells and how they might elicit an inflammatory response remain unknown. The project aims to achieve a first in-depth characterisation of ferroptotic DAMPs, characterise inflammatory signaling events relevant to bystander cells and to study the role of ferroptosis on immune cell activation in vivo.

Recent Publications

2025

Roeck BF, Lotfipour Nasudivar S, Vorndran MRH, Schueller L, Yapici FI, Rübsam M, von Karstedt S, Niessen CM, Garcia-Saez AJ. Ferroptosis spreads to neighboring cells via plasma membrane contacts. Nat Commun. 2025 Mar 26;16(1):2951. doi: 10.1038/s41467-025-58175-w. PMID: 40140422; PMCID: PMC11947162.

Project A05 Publications 2nd Funding Period 2024 - 2027

2024

Project A05 Publications 1st Funding Period 2020 - 2023

2023

2022

2021

Montinaro, A., Areso Zubiaur, I., Saggau, J., Kretz, A-L-, Ferreira, R.M.M., Hassan, O., Kitzig, E., Müller, I., El-Bahrawy, M.A., von Karstedt, S., Kulms, D., Liccardi, G., Lemke J. & Walczak, H. (2021) Potent pro-apoptotic combination therapy is highly effective in a broad range of cancers. Cell Death Differentiation. https://doi.org/10.1038/s41418-021-00869-x

Bebber, C.M., Thomas, E.S., Stroh, J., Chen, Z., Androulidaki, A., Schmitt, A., Höhne, M.N., Stüker, L., de Pádua Alves,C., Khonsari, A., Dammert, M.A., Parmaksiz, F., Tumbrink, H.L., Beleggia, F., Sos, M.L., Riemer, J., George, J., Brodesser, S., Thomas, R.K., Reinhardt, H.C. & von Karstedt, S. (2021) Ferroptosis response segregates small cell lung cancer (SCLC) neuroendocrine subtypes. Nature Communications volume 12, Article number: 2048. https://doi.org/10.1038/s41467-021-22336-4

2020

Clemente, L.P., Rabenau, M., Tang, S., Stanka, J., Cors, E., Stroh, J.,Culmsee, C., von Karstedt, S. (2020) Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration. Cells Oct 9;9(10):E2259. doi: 10.3390/cells9102259

Bebber, C.M., Müller, F., Clemente, L.P., Weber, J., von Karstedt, S., (2020). Ferroptosis in Cancer Cell Biology. Cancers (Basel) 2020 Jan; 12(1):164.

Project related Publications

2015 - 2019

Lim, J.K.M., Delaidelli, A., Minaker, S.W., Zhang, H.-F., Colovic, M., Yang, H., Negri, G.L., Karstedt, von, S., Lockwood, W.W., Schaffer, P., et al. (2019). Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance. Proc. Natl. Acad. Sci. U.S.A. 1092, 201821323.

Hartwig, T.*, Montinaro, A.*, von Karstedt, S.*, Sevko, A., Surinova, S., Chakravarthy, A., Taraborrelli, L., Draber, P., Lafont, E., Arce Vargas, F., et al. (2017). The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2. Mol. Cell 65, 730–742.e5. * These authors contributed equally to this work.

von Karstedt, S., Conti, A., Nobis, M., Montinaro, A., Hartwig, T., Lemke, J., Legler, K., Annewanter, F., Campbell, A.D., Taraborrelli, L., et al. (2015). Cancer cell-autonomous TRAIL-R signaling promotes KRAS-driven cancer progression, invasion, and metastasis. Cancer Cell 27, 561–573.

von Karstedt, S.*, Montinaro, A.*, and Walczak, H. (2017). Exploring the TRAILs less travelled: TRAIL in cancer biology and therapy. Nat. Rev. Cancer 17, 352–366. * These authors contributed equally to this work.

Patents: Named inventors: H. Walczak, S. von Karstedt; Methods for treating cancer (publication date 08.01.2015; WO2015001345)

UNIVERSITÄT ZU KÖLN

Sonderforschungsbereich 1403