Decoding the transduction network activated in response to plasma membrane damage during regulated necrosis
Uris Ros - Assoc.
Department of Membrane Dynamics, Max-Planck-Institute of Biophysics
Frankfurt am Main
Contact: Uris.Ros
biophys.mpg.de
For more information visit: Ros Lab
Abstract
Intracellular calcium elevation has emerged as a key signaling hub downstream of plasma membrane damage, where different forms of regulated necrosis - including pyroptosis, necroptosis and ferroptosis - converge. However, the interplay between this pathway and primary effectors of membrane damage, such as gasdermins in pyroptosis and MLKL in necroptosis, remains poorly understood. Even less is known about how it links regulated necrosis to other cellular processes, including membrane repair, gene expression, lipid scrambling, and immune activation. Our goal is to dissect the components of the calcium signaling pathway that are activated during different forms of regulated necrosis and to elucidate the molecular mechanisms underlying these processes. We use an integrative approach that combines multiscale screening methods with state-of-the-art molecular and cell biology, biochemistry, and membrane biophysics.
