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Bauernfried, S., Hornung, V.

DPP9 restrains NLRP1 activation


NLRP1 was the first inflammasome-forming sensor to be identified, but only recently has its mode of action been in the spotlight. Two groups now report cryo-EM structures demonstrating how NLRP1 is kept in check by the dipeptidyl peptidase DPP9, and they illuminate how DPP9 inhibition leads to NLRP1 inflammasome activation.

Read more at Nat Struct Mol Biol (2021)